| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Capital Research Global Investors | 5,939,553 | 365,995,000 | 15.81% | ||
| 2 | FMR LLC | 3,544,628 | 218,419,000 | 9.44% | ||
| 3 | VANGUARD GROUP INC | 2,629,342 | 162,020,000 | 7.00% | ||
| 4 | Wildcat Capital Management, LLC | 2,358,084 | 145,305,000 | 6.28% | ||
| 5 | JPMORGAN CHASE & CO | 2,260,173 | 139,272,000 | 6.02% | ||
| 6 | VIKING GLOBAL INVESTORS LP | 2,207,203 | 136,008,000 | 5.88% | ||
| 7 | BlackRock Fund Advisors | 1,315,703 | 81,074,000 | 3.50% | ||
| 8 | Capital World Investors | 1,296,000 | 79,860,000 | 3.45% | ||
| 9 | STATE STREET CORP | 1,019,666 | 62,831,000 | 2.71% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 893,935 | 55,084,000 | 2.38% | ||
| 11 | BB BIOTECH AG | 750,000 | 46,215,000 | 2.00% | ||
| 12 | Capital International Investors | 724,700 | 44,656,000 | 1.93% | ||
| 13 | CITADEL ADVISORS LLC | 559,319 | 34,465,000 | 1.49% | ||
| 14 | PFM Health Sciences, LP | 556,433 | 34,287,000 | 1.48% | ||
| 15 | RS INVESTMENT MANAGEMENT CO LLC | 485,051 | 29,889,000 | 1.29% | ||
| 16 | CAPITAL GUARDIAN TRUST CO | 457,600 | 28,197,000 | 1.22% | ||
| 17 | RTW INVESTMENTS, LP | 411,143 | 25,335,000 | 1.09% | ||
| 18 | MENORA MIVTACHIM HOLDINGS LTD. | 399,988 | 24,648,000 | 1.06% | ||
| 19 | FRANKLIN RESOURCES INC | 399,744 | 24,632,000 | 1.06% | ||
| 20 | J.P. Morgan Private Wealth Advisors LLC | 367,833 | 22,666,000 | 0.98% | ||
| 21 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 367,411 | 22,639,000 | 0.98% | ||
| 22 | Artal Group S.A. | 350,000 | 21,567,000 | 0.93% | ||
| 23 | ROYAL BANK OF CANADA | 337,787 | 20,814,000 | 0.90% | ||
| 24 | NORTHERN TRUST CORP | 334,956 | 20,640,000 | 0.89% | ||
| 25 | NORGES BANK | 322,946 | 19,900,000 | 0.86% | ||
| 26 | DSAM Partners (London) Ltd | 312,937 | 19,283,000 | 0.83% | ||
| 27 | AMERICAN CENTURY COMPANIES INC | 285,536 | 17,595,000 | 0.76% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 268,426 | 16,540,000 | 0.71% | ||
| 29 | FRONTIER CAPITAL MANAGEMENT CO LLC | 256,764 | 15,822,000 | 0.68% | ||
| 30 | LLBH PRIVATE WEALTH MANAGEMENT, LLC | 250,040 | 15,407,000 | 0.67% | ||
| 31 | UBS Group AG | 188,732 | 11,630,000 | 0.50% | ||
| 32 | Bank of New York Mellon Corp | 180,591 | 11,127,000 | 0.48% | ||
| 33 | MARSHALL WACE, LLP | 177,311 | 10,926,000 | 0.47% | ||
| 34 | EcoR1 Capital, LLC | 166,000 | 10,229,000 | 0.44% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 157,500 | 9,705,000 | 0.42% | Put | |
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 157,253 | 9,690,000 | 0.42% | ||
| 37 | Artal Group S.A. | 150,000 | 9,243,000 | 0.40% | Call | |
| 38 | Senator Investment Group LP | 150,000 | 9,243,000 | 0.40% | ||
| 39 | EVENTIDE ASSET MANAGEMENT, LLC | 148,600 | 9,157,000 | 0.40% | ||
| 40 | LORD, ABBETT & CO. LLC | 144,611 | 8,911,000 | 0.38% | ||
| 41 | Candriam S.C.A. | 126,000 | 7,764,000 | 0.34% | ||
| 42 | DEUTSCHE BANK AG\ | 120,874 | 7,447,000 | 0.32% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 116,557 | 7,183,000 | 0.31% | ||
| 44 | Zurcher Kantonalbank (Zurich Cantonalbank) | 109,667 | 6,758,000 | 0.29% | ||
| 45 | Silver Rock Financial LLC | 109,199 | 6,729,000 | 0.29% | ||
| 46 | BALYASNY ASSET MANAGEMENT L.P. | 106,059 | 6,535,000 | 0.28% | ||
| 47 | Invesco Ltd. | 104,395 | 6,433,000 | 0.28% | ||
| 48 | MIGDAL INSURANCE & FINANCIAL HOLDINGS LTD. | 100,000 | 6,162,000 | 0.27% | ||
| 49 | GUGGENHEIM CAPITAL LLC | 98,884 | 6,093,000 | 0.26% | ||
| 50 | BlackRock Investment Management, LLC | 96,738 | 5,961,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
