| 1 |
GOLDMAN SACHS GROUP INC |
3,457,325 |
66,519,000 |
27.12% |
|
|
| 2 |
Aisling Capital LLC |
2,523,300 |
48,548,000 |
19.79% |
|
|
| 3 |
Polaris Venture Management Co. V, L.L.C. |
2,374,571 |
45,687,000 |
18.63% |
|
|
| 4 |
GILDER GAGNON HOWE & CO LLC |
1,413,976 |
27,205,000 |
11.09% |
|
|
| 5 |
WELLINGTON MANAGEMENT GROUP LLP |
861,890 |
16,583,000 |
6.76% |
|
|
| 6 |
Harvest Capital Strategies LLC |
320,000 |
6,157,000 |
2.51% |
|
|
| 7 |
Foresite Capital Management II, LLC |
228,421 |
4,395,000 |
1.79% |
|
|
| 8 |
FMR LLC |
217,900 |
4,192,000 |
1.71% |
|
|
| 9 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
167,952 |
3,231,000 |
1.32% |
|
|
| 10 |
BlackRock Fund Advisors |
164,305 |
3,161,000 |
1.29% |
|
|
| 11 |
VANGUARD GROUP INC |
153,749 |
2,958,000 |
1.21% |
|
|
| 12 |
RA CAPITAL MANAGEMENT, L.P. |
138,002 |
2,655,000 |
1.08% |
|
|
| 13 |
SABBY MANAGEMENT, LLC |
133,809 |
2,574,000 |
1.05% |
|
|
| 14 |
TIGER MANAGEMENT L.L.C. |
90,909 |
1,749,000 |
0.71% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
62,956 |
1,211,000 |
0.49% |
|
|
| 16 |
NORTHERN TRUST CORP |
59,824 |
1,151,000 |
0.47% |
|
|
| 17 |
COLUMBUS CIRCLE INVESTORS |
51,800 |
997,000 |
0.41% |
|
|
| 18 |
STATE STREET CORP |
45,700 |
879,000 |
0.36% |
|
|
| 19 |
WOODSTOCK CORP |
29,070 |
559,000 |
0.23% |
|
|
| 20 |
CITIGROUP INC |
28,706 |
553,000 |
0.23% |
|
|
| 21 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
28,206 |
543,000 |
0.22% |
|
|
| 22 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
27,930 |
537,000 |
0.22% |
|
|
| 23 |
GEODE CAPITAL MANAGEMENT, LLC |
27,909 |
536,000 |
0.22% |
|
|
| 24 |
MORGAN STANLEY |
24,558 |
472,000 |
0.19% |
|
|
| 25 |
CADENCE CAPITAL MANAGEMENT LLC |
21,240 |
409,000 |
0.17% |
|
|
| 26 |
BlackRock Investment Management, LLC |
17,099 |
329,000 |
0.13% |
|
|
| 27 |
Bank of New York Mellon Corp |
16,428 |
316,000 |
0.13% |
|
|
| 28 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
11,047 |
213,000 |
0.09% |
|
|
| 29 |
ClariVest Asset Management LLC |
8,925 |
171,000 |
0.07% |
|
|
| 30 |
TEACHERS ADVISORS, LLC |
7,967 |
153,000 |
0.06% |
|
|
| 31 |
Senvest Management, LLC |
6,195 |
119,000 |
0.05% |
|
|
| 32 |
TCI Wealth Advisors, Inc. |
4,900 |
94,000 |
0.04% |
|
|
| 33 |
Nationwide Fund Advisors |
4,492 |
86,000 |
0.04% |
|
|
| 34 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,760 |
72,342 |
0.03% |
|
|
| 35 |
DEUTSCHE BANK AG\ |
3,542 |
68,000 |
0.03% |
|
|
| 36 |
WELLS FARGO & COMPANY/MN |
2,927 |
56,000 |
0.02% |
|
|
| 37 |
BLACKROCK ADVISORS LLC |
2,307 |
44,000 |
0.02% |
|
|
| 38 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,479 |
29,000 |
0.01% |
|
|
| 39 |
UBS Group AG |
1,044 |
20,000 |
0.01% |
|
|
| 40 |
Sensible Financial Planning & Management, LLC. |
610 |
12,000 |
0.00% |
|
|
| 41 |
BARCLAYS PLC |
486 |
9,000 |
0.00% |
|
|
| 42 |
BlackRock Japan Co. Ltd |
373 |
7,000 |
0.00% |
|
|
| 43 |
FIRST MANHATTAN CO. LLC. |
250 |
4,000 |
0.00% |
|
|
| 44 |
ROYAL BANK OF CANADA |
9 |
0 |
0.00% |
|
|
