| 1 |
GOLDMAN SACHS GROUP INC |
3,474,899 |
56,397,000 |
24.92% |
|
|
| 2 |
Aisling Capital LLC |
2,523,300 |
40,953,000 |
18.10% |
|
|
| 3 |
Polaris Venture Management Co. V, L.L.C. |
2,269,578 |
36,835,000 |
16.28% |
|
|
| 4 |
GILDER GAGNON HOWE & CO LLC |
1,316,113 |
21,361,000 |
9.44% |
|
|
| 5 |
WELLINGTON MANAGEMENT GROUP LLP |
741,725 |
12,038,000 |
5.32% |
|
|
| 6 |
Senvest Management, LLC |
539,666 |
8,759,000 |
3.87% |
|
|
| 7 |
PRICE T ROWE ASSOCIATES INC /MD/ |
467,491 |
7,587,000 |
3.35% |
|
|
| 8 |
MILLENNIUM MANAGEMENT LLC |
312,730 |
5,076,000 |
2.24% |
|
|
| 9 |
Harvest Capital Strategies LLC |
275,000 |
4,463,000 |
1.97% |
|
|
| 10 |
VANGUARD GROUP INC |
271,515 |
4,407,000 |
1.95% |
|
|
| 11 |
BlackRock Fund Advisors |
238,401 |
3,869,000 |
1.71% |
|
|
| 12 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
185,803 |
3,016,000 |
1.33% |
|
|
| 13 |
Point72 Asset Management, L.P. |
175,854 |
2,854,000 |
1.26% |
|
|
| 14 |
RA CAPITAL MANAGEMENT, L.P. |
138,002 |
2,240,000 |
0.99% |
|
|
| 15 |
AlpInvest Partners B.V. |
134,087 |
2,176,000 |
0.96% |
|
|
| 16 |
SABBY MANAGEMENT, LLC |
97,208 |
1,578,000 |
0.70% |
|
|
| 17 |
COLUMBUS CIRCLE INVESTORS |
86,450 |
1,403,000 |
0.62% |
|
|
| 18 |
NORTHERN TRUST CORP |
76,379 |
1,239,000 |
0.55% |
|
|
| 19 |
STATE STREET CORP |
60,805 |
989,000 |
0.44% |
|
|
| 20 |
BlackRock Institutional Trust Company, N.A. |
56,727 |
921,000 |
0.41% |
|
|
| 21 |
MORGAN STANLEY |
46,788 |
760,000 |
0.34% |
|
|
| 22 |
GEODE CAPITAL MANAGEMENT, LLC |
37,808 |
613,000 |
0.27% |
|
|
| 23 |
WOODSTOCK CORP |
37,329 |
606,000 |
0.27% |
|
|
| 24 |
Bank of New York Mellon Corp |
37,016 |
601,000 |
0.27% |
|
|
| 25 |
FRED ALGER MANAGEMENT, LLC |
35,200 |
571,000 |
0.25% |
|
|
| 26 |
BlackRock Investment Management, LLC |
31,573 |
512,000 |
0.23% |
|
|
| 27 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
30,540 |
496,000 |
0.22% |
|
|
| 28 |
Granite Investment Partners, LLC |
28,308 |
460,000 |
0.20% |
|
|
| 29 |
RENAISSANCE TECHNOLOGIES LLC |
23,590 |
383,000 |
0.17% |
|
|
| 30 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
23,152 |
376,000 |
0.17% |
|
|
| 31 |
D. E. Shaw & Co., Inc. |
20,659 |
335,000 |
0.15% |
|
|
| 32 |
TWO SIGMA INVESTMENTS, LP |
20,030 |
325,000 |
0.14% |
|
|
| 33 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
16,600 |
269,000 |
0.12% |
|
|
| 34 |
A.R.T. Advisors, LLC |
16,164 |
262,000 |
0.12% |
|
|
| 35 |
TEACHERS ADVISORS, LLC |
13,325 |
216,000 |
0.10% |
|
|
| 36 |
PNC FINANCIAL SERVICES GROUP, INC. |
12,700 |
205,000 |
0.09% |
|
|
| 37 |
ClariVest Asset Management LLC |
12,194 |
198,000 |
0.09% |
|
|
| 38 |
Weiss Multi-Strategy Advisers LLC |
10,000 |
162,000 |
0.07% |
|
|
| 39 |
NEW YORK STATE COMMON RETIREMENT FUND |
8,300 |
135,000 |
0.06% |
|
|
| 40 |
DEUTSCHE BANK AG\ |
8,248 |
132,000 |
0.06% |
|
|
| 41 |
Nationwide Fund Advisors |
5,810 |
94,000 |
0.04% |
|
|
| 42 |
AMERICAN INTERNATIONAL GROUP, INC. |
5,326 |
86,441 |
0.04% |
|
|
| 43 |
TCI Wealth Advisors, Inc. |
4,900 |
80,000 |
0.04% |
|
|
| 44 |
BLACKROCK ADVISORS LLC |
4,852 |
79,000 |
0.03% |
|
|
| 45 |
Invesco Ltd. |
2,942 |
48,000 |
0.02% |
|
|
| 46 |
Cubist Systematic Strategies, LLC |
2,897 |
47,000 |
0.02% |
|
|
| 47 |
PANAGORA ASSET MANAGEMENT INC |
2,521 |
41,000 |
0.02% |
|
|
| 48 |
BNP PARIBAS FINANCIAL MARKETS |
757 |
12,286 |
0.01% |
|
|
| 49 |
Sensible Financial Planning & Management, LLC. |
610 |
10,000 |
0.00% |
|
|
| 50 |
ROYAL BANK OF CANADA |
510 |
8,000 |
0.00% |
|
|
