| 1 |
GOLDMAN SACHS GROUP INC |
4,223,416 |
41,642,000 |
22.72% |
|
|
| 2 |
Aisling Capital LLC |
2,830,992 |
27,914,000 |
15.23% |
|
|
| 3 |
Polaris Venture Management Co. V, L.L.C. |
2,018,450 |
19,902,000 |
10.86% |
|
|
| 4 |
WELLINGTON MANAGEMENT GROUP LLP |
1,623,994 |
16,012,000 |
8.74% |
|
|
| 5 |
Senvest Management, LLC |
1,310,489 |
12,921,000 |
7.05% |
|
|
| 6 |
Point72 Asset Management, L.P. |
1,100,000 |
10,846,000 |
5.92% |
|
|
| 7 |
Lagoda Investment Management, L.P. |
1,071,246 |
10,562,000 |
5.76% |
|
|
| 8 |
FLAGSHIP VENTURES FUND IV, L.P. |
741,755 |
7,314,000 |
3.99% |
|
|
| 9 |
TIGER MANAGEMENT L.L.C. |
552,255 |
5,445,000 |
2.97% |
|
|
| 10 |
VANGUARD GROUP INC |
479,211 |
4,725,000 |
2.58% |
|
|
| 11 |
GILDER GAGNON HOWE & CO LLC |
440,968 |
4,348,000 |
2.37% |
|
|
| 12 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
340,420 |
3,357,000 |
1.83% |
|
|
| 13 |
PRICE T ROWE ASSOCIATES INC /MD/ |
337,885 |
3,332,000 |
1.82% |
|
|
| 14 |
BlackRock Fund Advisors |
275,057 |
2,712,000 |
1.48% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
196,264 |
1,935,000 |
1.06% |
|
|
| 16 |
SABBY MANAGEMENT, LLC |
145,000 |
1,430,000 |
0.78% |
|
|
| 17 |
NORTHERN TRUST CORP |
134,383 |
1,325,000 |
0.72% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
100,150 |
987,000 |
0.54% |
|
|
| 19 |
STATE STREET CORP |
93,844 |
927,000 |
0.51% |
|
|
| 20 |
Spark Investment Management LLC |
73,300 |
722,000 |
0.39% |
|
|
| 21 |
Bank of New York Mellon Corp |
37,670 |
371,000 |
0.20% |
|
|
| 22 |
WOODSTOCK CORP |
37,329 |
368,000 |
0.20% |
|
|
| 23 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
34,623 |
341,000 |
0.19% |
|
|
| 24 |
BlackRock Investment Management, LLC |
33,609 |
331,000 |
0.18% |
|
|
| 25 |
UBS Group AG |
32,700 |
322,000 |
0.18% |
|
|
| 26 |
TFS CAPITAL LLC |
31,932 |
315,000 |
0.17% |
|
|
| 27 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
31,020 |
306,000 |
0.17% |
|
|
| 28 |
MORGAN STANLEY |
30,946 |
305,000 |
0.17% |
|
|
| 29 |
Weiss Multi-Strategy Advisers LLC |
25,000 |
247,000 |
0.13% |
|
|
| 30 |
D. E. Shaw & Co., Inc. |
23,115 |
228,000 |
0.12% |
|
|
| 31 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
22,929 |
226,000 |
0.12% |
|
|
| 32 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
21,600 |
213,000 |
0.12% |
|
|
| 33 |
TEACHERS ADVISORS, LLC |
16,615 |
164,000 |
0.09% |
|
|
| 34 |
DEUTSCHE BANK AG\ |
14,534 |
142,000 |
0.08% |
|
|
| 35 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
14,054 |
139,000 |
0.08% |
|
|
| 36 |
ROCKEFELLER FINANCIAL SERVICES INC |
11,766 |
116,000 |
0.06% |
|
|
| 37 |
DENVER INVESTMENT ADVISORS LLC |
10,416 |
103,000 |
0.06% |
|
|
| 38 |
NEW YORK STATE COMMON RETIREMENT FUND |
8,300 |
82,000 |
0.04% |
|
|
| 39 |
NISA INVESTMENT ADVISORS, LLC |
8,000 |
79,000 |
0.04% |
|
|
| 40 |
CITIGROUP INC |
7,667 |
76,000 |
0.04% |
|
|
| 41 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
8,053 |
73,000 |
0.04% |
|
|
| 42 |
Nationwide Fund Advisors |
6,483 |
64,000 |
0.03% |
|
|
| 43 |
BLACKROCK ADVISORS LLC |
5,559 |
55,000 |
0.03% |
|
|
| 44 |
AMERICAN INTERNATIONAL GROUP, INC. |
5,422 |
53,000 |
0.03% |
|
|
| 45 |
TCI Wealth Advisors, Inc. |
4,900 |
48,000 |
0.03% |
|
|
| 46 |
WELLS FARGO & COMPANY/MN |
4,392 |
43,000 |
0.02% |
|
|
| 47 |
PNC FINANCIAL SERVICES GROUP, INC. |
4,000 |
40,000 |
0.02% |
|
|
| 48 |
JPMORGAN CHASE & CO |
3,074 |
30,000 |
0.02% |
|
|
| 49 |
BANK OF MONTREAL /CAN/ |
2,035 |
20,000 |
0.01% |
|
|
| 50 |
BANK OF AMERICA CORP /DE/ |
1,317 |
13,000 |
0.01% |
|
|
