| 1 |
GOLDMAN SACHS GROUP INC |
4,174,887 |
45,673,000 |
23.05% |
|
|
| 2 |
Aisling Capital LLC |
2,830,992 |
30,971,000 |
15.63% |
|
|
| 3 |
Polaris Venture Management Co. V, L.L.C. |
2,018,450 |
22,082,000 |
11.14% |
|
|
| 4 |
WELLINGTON MANAGEMENT GROUP LLP |
1,676,600 |
18,342,000 |
9.26% |
|
|
| 5 |
Point72 Asset Management, L.P. |
1,100,000 |
12,034,000 |
6.07% |
|
|
| 6 |
Senvest Management, LLC |
961,606 |
10,520,000 |
5.31% |
|
|
| 7 |
FLAGSHIP VENTURES FUND IV GENERAL PARTNER LLC |
741,755 |
8,115,000 |
4.10% |
|
|
| 8 |
GILDER GAGNON HOWE & CO LLC |
474,017 |
5,186,000 |
2.62% |
|
|
| 9 |
PRICE T ROWE ASSOCIATES INC /MD/ |
471,113 |
5,154,000 |
2.60% |
|
|
| 10 |
VANGUARD GROUP INC |
440,434 |
4,818,000 |
2.43% |
|
|
| 11 |
TIGER MANAGEMENT L.L.C. |
422,931 |
4,627,000 |
2.33% |
|
|
| 12 |
Lagoda Investment Management, L.P. |
395,413 |
4,326,000 |
2.18% |
|
|
| 13 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
340,910 |
3,730,000 |
1.88% |
|
|
| 14 |
BlackRock Fund Advisors |
270,145 |
2,955,000 |
1.49% |
|
|
| 15 |
MILLENNIUM MANAGEMENT LLC |
253,370 |
2,772,000 |
1.40% |
|
|
| 16 |
SABBY MANAGEMENT, LLC |
230,542 |
2,522,000 |
1.27% |
|
|
| 17 |
BlackRock Institutional Trust Company, N.A. |
223,279 |
2,443,000 |
1.23% |
|
|
| 18 |
AlpInvest Partners B.V. |
134,087 |
1,467,000 |
0.74% |
|
|
| 19 |
NORTHERN TRUST CORP |
129,716 |
1,419,000 |
0.72% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
97,912 |
1,071,000 |
0.54% |
|
|
| 21 |
STATE STREET CORP |
75,718 |
829,000 |
0.42% |
|
|
| 22 |
Spark Investment Management LLC |
73,300 |
801,000 |
0.40% |
|
|
| 23 |
MORGAN STANLEY |
50,813 |
555,000 |
0.28% |
|
|
| 24 |
Bank of New York Mellon Corp |
38,857 |
425,000 |
0.21% |
|
|
| 25 |
WOODSTOCK CORP |
37,329 |
408,000 |
0.21% |
|
|
| 26 |
BlackRock Investment Management, LLC |
31,985 |
350,000 |
0.18% |
|
|
| 27 |
Espalier Global Management LLC |
31,250 |
342,000 |
0.17% |
|
|
| 28 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
31,206 |
341,000 |
0.17% |
|
|
| 29 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
29,520 |
323,000 |
0.16% |
|
|
| 30 |
CITADEL ADVISORS LLC |
26,466 |
289,000 |
0.15% |
|
|
| 31 |
Weiss Multi-Strategy Advisers LLC |
25,000 |
274,000 |
0.14% |
|
|
| 32 |
Quantitative Systematic Strategies LLC |
24,818 |
272,000 |
0.14% |
|
|
| 33 |
TFS CAPITAL LLC |
24,656 |
270,000 |
0.14% |
|
|
| 34 |
RENAISSANCE TECHNOLOGIES LLC |
22,200 |
243,000 |
0.12% |
|
|
| 35 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
21,600 |
237,000 |
0.12% |
|
|
| 36 |
RTW INVESTMENTS, LP |
20,900 |
229,000 |
0.12% |
|
|
| 37 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
19,860 |
217,000 |
0.11% |
|
|
| 38 |
NOMURA HOLDINGS INC |
19,300 |
209,000 |
0.11% |
|
|
| 39 |
BANK OF AMERICA CORP /DE/ |
16,184 |
177,000 |
0.09% |
|
|
| 40 |
DEUTSCHE BANK AG\ |
15,805 |
172,000 |
0.09% |
|
|
| 41 |
TEACHERS ADVISORS, LLC |
13,325 |
146,000 |
0.07% |
|
|
| 42 |
D. E. Shaw & Co., Inc. |
12,763 |
140,000 |
0.07% |
|
|
| 43 |
ADA INVESTMENT MANAGEMENT, LP |
12,485 |
137,000 |
0.07% |
|
|
| 44 |
NEW YORK STATE COMMON RETIREMENT FUND |
8,300 |
91,000 |
0.05% |
|
|
| 45 |
Nationwide Fund Advisors |
6,382 |
70,000 |
0.04% |
|
|
| 46 |
BLACKROCK ADVISORS LLC |
6,081 |
67,000 |
0.03% |
|
|
| 47 |
AMERICAN INTERNATIONAL GROUP, INC. |
5,422 |
59,000 |
0.03% |
|
|
| 48 |
TCI Wealth Advisors, Inc. |
4,900 |
54,000 |
0.03% |
|
|
| 49 |
PNC FINANCIAL SERVICES GROUP, INC. |
4,000 |
44,000 |
0.02% |
|
|
| 50 |
UBS Group AG |
3,275 |
36,000 |
0.02% |
|
|
