| 1 |
GOLDMAN SACHS GROUP INC |
3,457,252 |
53,657,000 |
24.86% |
|
|
| 2 |
Aisling Capital LLC |
2,523,300 |
39,162,000 |
18.15% |
|
|
| 3 |
Polaris Venture Management Co. V, L.L.C. |
2,374,571 |
36,853,000 |
17.08% |
|
|
| 4 |
GILDER GAGNON HOWE & CO LLC |
1,331,826 |
20,670,000 |
9.58% |
|
|
| 5 |
WELLINGTON MANAGEMENT GROUP LLP |
879,313 |
13,647,000 |
6.32% |
|
|
| 6 |
Senvest Management, LLC |
511,366 |
7,936,000 |
3.68% |
|
|
| 7 |
Harvest Capital Strategies LLC |
356,900 |
5,539,000 |
2.57% |
|
|
| 8 |
PRICE T ROWE ASSOCIATES INC /MD/ |
354,428 |
5,501,000 |
2.55% |
|
|
| 9 |
Foresite Capital Management II, LLC |
233,019 |
3,616,000 |
1.68% |
|
|
| 10 |
VANGUARD GROUP INC |
173,246 |
2,688,000 |
1.25% |
|
|
| 11 |
BlackRock Fund Advisors |
172,334 |
2,675,000 |
1.24% |
|
|
| 12 |
SABBY MANAGEMENT, LLC |
161,650 |
2,509,000 |
1.16% |
|
|
| 13 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
148,027 |
2,297,000 |
1.06% |
|
|
| 14 |
RA CAPITAL MANAGEMENT, L.P. |
138,002 |
2,142,000 |
0.99% |
|
|
| 15 |
AlpInvest Partners B.V. |
134,087 |
2,081,000 |
0.96% |
|
|
| 16 |
MILLENNIUM MANAGEMENT LLC |
105,656 |
1,640,000 |
0.76% |
|
|
| 17 |
TIGER MANAGEMENT L.L.C. |
90,909 |
1,411,000 |
0.65% |
|
|
| 18 |
NORTHERN TRUST CORP |
68,112 |
1,057,000 |
0.49% |
|
|
| 19 |
HAMILTON LANE ADVISORS LLC |
64,226 |
997,000 |
0.46% |
|
|
| 20 |
BlackRock Institutional Trust Company, N.A. |
62,443 |
969,000 |
0.45% |
|
|
| 21 |
STATE STREET CORP |
60,929 |
947,000 |
0.44% |
|
|
| 22 |
COLUMBUS CIRCLE INVESTORS |
51,800 |
804,000 |
0.37% |
|
|
| 23 |
RENAISSANCE TECHNOLOGIES LLC |
44,592 |
692,000 |
0.32% |
|
|
| 24 |
MORGAN STANLEY |
38,253 |
594,000 |
0.28% |
|
|
| 25 |
WOODSTOCK CORP |
37,329 |
579,000 |
0.27% |
|
|
| 26 |
GEODE CAPITAL MANAGEMENT, LLC |
35,006 |
543,000 |
0.25% |
|
|
| 27 |
Invesco Private Capital, Inc. |
35,000 |
543,000 |
0.25% |
|
|
| 28 |
Bank of New York Mellon Corp |
32,558 |
505,000 |
0.23% |
|
|
| 29 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
29,850 |
463,000 |
0.21% |
|
|
| 30 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
28,206 |
438,000 |
0.20% |
|
|
| 31 |
CADENCE CAPITAL MANAGEMENT LLC |
26,960 |
418,000 |
0.19% |
|
|
| 32 |
DEUTSCHE BANK AG\ |
21,080 |
326,000 |
0.15% |
|
|
| 33 |
Dynamic Technology Lab Private Ltd |
18,438 |
286,000 |
0.13% |
|
|
| 34 |
BlackRock Investment Management, LLC |
17,884 |
278,000 |
0.13% |
|
|
| 35 |
A.R.T. Advisors, LLC |
12,543 |
194,000 |
0.09% |
|
|
| 36 |
StepStone Group LP |
12,100 |
188,000 |
0.09% |
|
|
| 37 |
ClariVest Asset Management LLC |
12,094 |
187,000 |
0.09% |
|
|
| 38 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
11,047 |
171,000 |
0.08% |
|
|
| 39 |
PNC FINANCIAL SERVICES GROUP, INC. |
9,700 |
150,000 |
0.07% |
|
|
| 40 |
TEACHERS ADVISORS, LLC |
7,967 |
124,000 |
0.06% |
|
|
| 41 |
TCI Wealth Advisors, Inc. |
4,900 |
76,000 |
0.04% |
|
|
| 42 |
Nationwide Fund Advisors |
4,492 |
70,000 |
0.03% |
|
|
| 43 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,780 |
58,665 |
0.03% |
|
|
| 44 |
BLACKROCK ADVISORS LLC |
2,785 |
43,000 |
0.02% |
|
|
| 45 |
ALLIANCEBERNSTEIN L.P. |
1,000 |
16,000 |
0.01% |
|
|
| 46 |
Tower Research Capital LLC (TRC) |
839 |
13,000 |
0.01% |
|
|
| 47 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
672 |
10,000 |
0.00% |
|
|
| 48 |
CITIGROUP INC |
463 |
7,000 |
0.00% |
|
|
| 49 |
UBS Group AG |
450 |
7,000 |
0.00% |
|
|
| 50 |
WELLS FARGO & COMPANY/MN |
301 |
5,000 |
0.00% |
|
|
