| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JENNISON ASSOCIATES LLC | 2,672,377 | 12,934,000 | 29.21% | ||
| 2 | ORBIMED ADVISORS LLC | 2,305,446 | 11,158,000 | 25.20% | ||
| 3 | BAKER BROS. ADVISORS LP | 1,234,095 | 5,973,000 | 13.49% | ||
| 4 | Redmile Group, LLC | 581,638 | 2,815,000 | 6.36% | ||
| 5 | Clearbridge Investments, LLC | 504,279 | 2,441,000 | 5.51% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 411,983 | 1,994,000 | 4.50% | ||
| 7 | FRANKLIN RESOURCES INC | 309,700 | 1,499,000 | 3.39% | ||
| 8 | FMR LLC | 237,916 | 1,152,000 | 2.60% | ||
| 9 | ALTRINSIC GLOBAL ADVISORS LLC | 205,000 | 992,000 | 2.24% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 187,866 | 909,000 | 2.05% | ||
| 11 | HIGHLAND CAPITAL MANAGEMENT LP | 153,217 | 741,000 | 1.67% | ||
| 12 | SABBY MANAGEMENT, LLC | 110,000 | 532,000 | 1.20% | ||
| 13 | PRINCIPAL FINANCIAL GROUP INC | 76,494 | 370,000 | 0.84% | ||
| 14 | Asset Management One Co., Ltd. | 42,090 | 194,000 | 0.44% | ||
| 15 | MORGAN STANLEY | 30,300 | 147,000 | 0.33% | ||
| 16 | CLEARBRIDGE, LLC | 18,100 | 88,000 | 0.20% | ||
| 17 | DEUTSCHE BANK AG\ | 14,907 | 71,000 | 0.16% | ||
| 18 | RENAISSANCE TECHNOLOGIES LLC | 13,000 | 63,000 | 0.14% | ||
| 19 | FT OPTIONS LLC | 12,523 | 61,000 | 0.14% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 10,939 | 52,000 | 0.12% | ||
| 21 | WELLS FARGO & COMPANY/MN | 8,071 | 39,000 | 0.09% | ||
| 22 | JPMORGAN CHASE & CO | 6,019 | 29,000 | 0.07% | ||
| 23 | UBS Group AG | 2,627 | 13,000 | 0.03% | ||
| 24 | Creative Planning | 1,500 | 7,000 | 0.02% | ||
| 25 | Tower Research Capital LLC (TRC) | 785 | 4,000 | 0.01% | ||
| 26 | ROYAL BANK OF CANADA | 523 | 3,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
