| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WASATCH ADVISORS LP | 2,715,000 | 13,412,000 | 22.13% | ||
| 2 | BELLEVUE ASSET MANAGEMENT AG | 2,169,625 | 10,718,000 | 17.68% | ||
| 3 | Tekla Capital Management LLC | 2,105,263 | 10,400,000 | 17.16% | ||
| 4 | FMR LLC | 1,666,667 | 8,233,000 | 13.58% | ||
| 5 | CLIFTON PARK CAPITAL MANAGEMENT, LLC | 1,590,000 | 7,727,000 | 12.75% | ||
| 6 | RA CAPITAL MANAGEMENT, L.P. | 940,000 | 4,568,000 | 7.54% | ||
| 7 | Opaleye Management Inc. | 355,000 | 1,725,000 | 2.85% | ||
| 8 | Alyeska Investment Group, L.P. | 264,839 | 1,287,000 | 2.12% | ||
| 9 | SECTORAL ASSET MANAGEMENT INC | 228,132 | 1,109,000 | 1.83% | ||
| 10 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 100,000 | 486,000 | 0.80% | ||
| 11 | SPHERA FUNDS MANAGEMENT LTD. | 63,967 | 316,000 | 0.52% | ||
| 12 | Omega Advisors Inc. | 35,868 | 174,000 | 0.29% | ||
| 13 | KEYBANK NATIONAL ASSOCIATION/OH | 30,779 | 150,000 | 0.25% | ||
| 14 | HARVEY CAPITAL MANAGEMENT INC | 20,900 | 116,000 | 0.19% | ||
| 15 | GOLDMAN SACHS GROUP INC | 19,082 | 93,000 | 0.15% | ||
| 16 | ROYAL BANK OF CANADA | 12,000 | 58,000 | 0.10% | ||
| 17 | UBS Group AG | 6,420 | 31,000 | 0.05% | ||
| 18 | BANK OF AMERICA CORP /DE/ | 732 | 4,000 | 0.01% | ||
| 19 | RUSSELL FRANK CO/ | 400 | 2,000 | 0.00% | ||
| 20 | MORGAN STANLEY | 497 | 2,000 | 0.00% | ||
| 21 | DEUTSCHE BANK AG\ | 200 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
