| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,115,292 | 40,719,000 | 12.56% | ||
| 2 | BAUPOST GROUP LLC/MA | 2,044,498 | 39,357,000 | 12.14% | ||
| 3 | BlackRock Finance, Inc. | 1,503,842 | 28,950,000 | 8.93% | ||
| 4 | Abingworth LLP | 1,301,413 | 25,052,000 | 7.73% | ||
| 5 | Tekla Capital Management LLC | 762,581 | 14,680,000 | 4.53% | ||
| 6 | VANGUARD GROUP INC | 724,300 | 13,942,000 | 4.30% | ||
| 7 | GREAT POINT PARTNERS LLC | 539,571 | 10,387,000 | 3.20% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 511,955 | 9,855,000 | 3.04% | ||
| 9 | Fortress Investment Group LLC | 433,804 | 8,350,000 | 2.58% | ||
| 10 | RENAISSANCE TECHNOLOGIES LLC | 414,513 | 7,979,000 | 2.46% | ||
| 11 | BALYASNY ASSET MANAGEMENT L.P. | 398,850 | 7,678,000 | 2.37% | ||
| 12 | BROWN BROTHERS HARRIMAN & CO | 367,902 | 7,082,000 | 2.19% | ||
| 13 | GENERAL AMERICAN INVESTORS CO INC | 307,213 | 5,914,000 | 1.82% | ||
| 14 | STATE STREET CORP | 290,256 | 5,589,000 | 1.72% | ||
| 15 | NORTHERN TRUST CORP | 261,899 | 5,041,000 | 1.56% | ||
| 16 | Granahan Investment Management, LLC | 253,200 | 4,874,000 | 1.50% | ||
| 17 | FRANKLIN RESOURCES INC | 245,692 | 4,730,000 | 1.46% | ||
| 18 | Roumell Asset Management, LLC | 243,983 | 4,697,000 | 1.45% | ||
| 19 | DEUTSCHE BANK AG\ | 240,286 | 4,623,000 | 1.43% | ||
| 20 | Broadfin Capital, LLC | 223,862 | 4,309,000 | 1.33% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 200,000 | 3,850,000 | 1.19% | Put | |
| 22 | MARSHALL WACE ASIA LTD | 171,488 | 3,258,000 | 1.01% | ||
| 23 | MARSHALL WACE NORTH AMERICA, L.P. | 171,488 | 3,258,000 | 1.01% | ||
| 24 | Boston Partners | 156,858 | 3,020,000 | 0.93% | ||
| 25 | MORGAN STANLEY | 154,693 | 2,978,000 | 0.92% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 148,962 | 2,867,000 | 0.88% | ||
| 27 | SPHERA FUNDS MANAGEMENT LTD. | 140,000 | 2,695,000 | 0.83% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 138,500 | 2,666,000 | 0.82% | Call | |
| 29 | ROYCE & ASSOCIATES LP | 132,600 | 2,553,000 | 0.79% | ||
| 30 | Candriam S.C.A. | 120,000 | 2,310,000 | 0.71% | ||
| 31 | CITADEL ADVISORS LLC | 105,850 | 2,037,000 | 0.63% | ||
| 32 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 100,000 | 1,925,000 | 0.59% | Put | |
| 33 | NORGES BANK | 96,500 | 1,858,000 | 0.57% | ||
| 34 | Bank of New York Mellon Corp | 84,045 | 1,618,000 | 0.50% | ||
| 35 | RAINIER INVESTMENT MANAGEMENT LLC | 79,170 | 1,524,000 | 0.47% | ||
| 36 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 77,860 | 1,499,000 | 0.46% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 75,076 | 1,445,000 | 0.45% | ||
| 38 | Parallax Volatility Advisers, L.P. | 72,300 | 1,392,000 | 0.43% | Put | |
| 39 | NEA Management Company, LLC | 66,245 | 1,275,000 | 0.39% | ||
| 40 | ESSEX INVESTMENT MANAGEMENT CO LLC | 51,426 | 990,000 | 0.31% | ||
| 41 | GOLDMAN SACHS GROUP INC | 50,000 | 963,000 | 0.30% | Call | |
| 42 | SUFFOLK CAPITAL MANAGEMENT LLC | 49,554 | 954,000 | 0.29% | ||
| 43 | Allianz Asset Management GmbH | 48,019 | 924,000 | 0.29% | ||
| 44 | BOOTHBAY FUND MANAGEMENT, LLC | 47,466 | 914,000 | 0.28% | ||
| 45 | BOOTHBAY FUND MANAGEMENT, LLC | 45,200 | 870,000 | 0.27% | Put | |
| 46 | GOLDMAN SACHS GROUP INC | 43,501 | 837,000 | 0.26% | ||
| 47 | Laurion Capital Management LP | 42,500 | 818,000 | 0.25% | Call | |
| 48 | Laurion Capital Management LP | 42,500 | 818,000 | 0.25% | Put | |
| 49 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 41,399 | 797,000 | 0.25% | ||
| 50 | CITADEL ADVISORS LLC | 41,100 | 791,000 | 0.24% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
