| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,899,721 | 70,409,000 | 9.10% | ||
| 2 | GILDER GAGNON HOWE & CO LLC | 4,244,971 | 61,000,000 | 7.88% | ||
| 3 | FMR LLC | 4,097,471 | 58,881,000 | 7.61% | ||
| 4 | ORACLE INVESTMENT MANAGEMENT INC | 3,723,407 | 53,505,359 | 6.91% | ||
| 5 | BLAIR WILLIAM & CO/IL | 3,685,063 | 52,954,000 | 6.84% | ||
| 6 | VANGUARD GROUP INC | 3,375,907 | 48,511,000 | 6.27% | ||
| 7 | Cortina Asset Management, LLC | 2,922,498 | 41,996,000 | 5.43% | ||
| 8 | RS INVESTMENT MANAGEMENT CO LLC | 1,717,328 | 24,678,000 | 3.19% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,713,404 | 24,622,000 | 3.18% | ||
| 10 | BROADVIEW ADVISORS LLC | 1,652,425 | 23,745,000 | 3.07% | ||
| 11 | BlackRock Fund Advisors | 1,542,955 | 22,172,000 | 2.86% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 1,272,853 | 18,291,000 | 2.36% | ||
| 13 | APG Asset Management N.V. | 1,210,000 | 17,388,000 | 2.25% | ||
| 14 | BANK OF MONTREAL /CAN/ | 1,080,106 | 15,521,000 | 2.01% | ||
| 15 | STATE STREET CORP | 1,010,905 | 14,527,000 | 1.88% | ||
| 16 | Tamarack Capital Management, LLC | 1,050,000 | 14,217,000 | 1.84% | ||
| 17 | Point72 Asset Management, L.P. | 973,200 | 13,985,000 | 1.81% | ||
| 18 | EverPoint Asset Management, LLC | 900,000 | 12,933,000 | 1.67% | ||
| 19 | ORBIMED ADVISORS LLC | 795,200 | 11,427,000 | 1.48% | ||
| 20 | NORTHERN TRUST CORP | 733,541 | 10,541,000 | 1.36% | ||
| 21 | WELLS FARGO & COMPANY/MN | 716,187 | 10,292,000 | 1.33% | ||
| 22 | TIVERTON ASSET MANAGEMENT LLC | 700,000 | 10,062,000 | 1.30% | ||
| 23 | ALTRINSIC GLOBAL ADVISORS LLC | 666,300 | 9,575,000 | 1.24% | ||
| 24 | WHV Investments, Inc. | 556,380 | 7,995,000 | 1.03% | ||
| 25 | Nuveen Asset Management, LLC | 534,930 | 7,687,000 | 0.99% | ||
| 26 | SECTORAL ASSET MANAGEMENT INC | 495,556 | 7,121,000 | 0.92% | ||
| 27 | DRILL CRAIG A | 473,200 | 6,800,000 | 0.88% | ||
| 28 | DAFNA Capital Management LLC | 384,154 | 5,520,000 | 0.71% | ||
| 29 | Paloma Partners Management Co | 367,400 | 5,280,000 | 0.68% | ||
| 30 | Weiss Multi-Strategy Advisers LLC | 335,000 | 4,814,000 | 0.62% | ||
| 31 | CASTLEARK MANAGEMENT LLC | 325,950 | 4,684,000 | 0.61% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 308,203 | 4,428,000 | 0.57% | ||
| 33 | Bank of New York Mellon Corp | 293,510 | 4,218,000 | 0.55% | ||
| 34 | LORD, ABBETT & CO. LLC | 260,708 | 3,746,000 | 0.48% | ||
| 35 | MILLENNIUM MANAGEMENT LLC | 239,300 | 3,439,000 | 0.44% | Call | |
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 234,502 | 3,370,000 | 0.44% | ||
| 37 | CLOUGH CAPITAL PARTNERS L P | 205,716 | 2,956,000 | 0.38% | ||
| 38 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 200,000 | 2,874,000 | 0.37% | ||
| 39 | Employees Retirement System of Texas | 198,000 | 2,845,000 | 0.37% | ||
| 40 | MANAGED ACCOUNT ADVISORS LLC | 190,866 | 2,743,000 | 0.35% | ||
| 41 | First Light Asset Management, LLC | 186,080 | 2,674,000 | 0.35% | ||
| 42 | BlackRock Investment Management, LLC | 167,674 | 2,409,000 | 0.31% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 166,628 | 2,395,000 | 0.31% | ||
| 44 | STATE OF WISCONSIN INVESTMENT BOARD | 163,220 | 2,345,000 | 0.30% | ||
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 156,100 | 2,243,000 | 0.29% | ||
| 46 | NORGES BANK | 153,904 | 2,212,000 | 0.29% | ||
| 47 | CONTINENTAL ADVISORS LLC | 138,064 | 1,984,000 | 0.26% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 122,092 | 1,754,000 | 0.23% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 112,170 | 1,612,000 | 0.21% | ||
| 50 | Sivik Global Healthcare LLC | 100,000 | 1,437,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
