| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,214,200 | 111,421,000 | 11.09% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,811,494 | 86,270,000 | 8.59% | ||
| 3 | GILDER GAGNON HOWE & CO LLC | 4,034,891 | 72,346,000 | 7.20% | ||
| 4 | ORACLE INVESTMENT MANAGEMENT INC | 3,754,343 | 67,315,000 | 6.70% | ||
| 5 | VANGUARD GROUP INC | 3,435,249 | 61,594,000 | 6.13% | ||
| 6 | LORD, ABBETT & CO. LLC | 2,970,646 | 53,264,000 | 5.30% | ||
| 7 | BLAIR WILLIAM & CO/IL | 2,650,064 | 47,516,000 | 4.73% | ||
| 8 | Cortina Asset Management, LLC | 2,381,692 | 42,704,000 | 4.25% | ||
| 9 | RS INVESTMENT MANAGEMENT CO LLC | 2,301,042 | 41,258,000 | 4.11% | ||
| 10 | BlackRock Fund Advisors | 1,728,907 | 30,999,000 | 3.09% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,646,027 | 29,513,000 | 2.94% | ||
| 12 | BROADVIEW ADVISORS LLC | 1,637,425 | 29,359,000 | 2.92% | ||
| 13 | BANK OF MONTREAL /CAN/ | 1,128,525 | 20,234,000 | 2.01% | ||
| 14 | Tamarack Capital Management, LLC | 1,100,000 | 19,723,000 | 1.96% | ||
| 15 | STATE STREET CORP | 1,005,826 | 18,036,000 | 1.80% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 998,681 | 17,906,000 | 1.78% | ||
| 17 | SECTORAL ASSET MANAGEMENT INC | 807,012 | 14,470,000 | 1.44% | ||
| 18 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 793,409 | 14,225,823 | 1.42% | ||
| 19 | WELLS FARGO & COMPANY/MN | 737,832 | 13,229,000 | 1.32% | ||
| 20 | NORTHERN TRUST CORP | 708,720 | 12,708,000 | 1.27% | ||
| 21 | TIVERTON ASSET MANAGEMENT LLC | 700,000 | 12,555,000 | 1.25% | ||
| 22 | OppenheimerFunds, Inc. | 668,016 | 11,978,000 | 1.19% | ||
| 23 | ALTRINSIC GLOBAL ADVISORS LLC | 666,300 | 11,947,000 | 1.19% | ||
| 24 | CASTLEARK MANAGEMENT LLC | 563,691 | 10,107,000 | 1.01% | ||
| 25 | Point72 Asset Management, L.P. | 495,200 | 8,879,000 | 0.88% | ||
| 26 | NEXT CENTURY GROWTH INVESTORS LLC | 428,873 | 7,689,000 | 0.77% | ||
| 27 | DAFNA Capital Management LLC | 384,154 | 6,888,000 | 0.69% | ||
| 28 | First Light Asset Management, LLC | 373,164 | 6,691,000 | 0.67% | ||
| 29 | Nuveen Asset Management, LLC | 367,675 | 6,592,000 | 0.66% | ||
| 30 | CHARTWELL INVESTMENT PARTNERS, LLC | 363,820 | 6,523,000 | 0.65% | ||
| 31 | WHV Investments, Inc. | 334,580 | 5,999,000 | 0.60% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 331,424 | 5,941,000 | 0.59% | ||
| 33 | Bank of New York Mellon Corp | 315,727 | 5,661,000 | 0.56% | ||
| 34 | Weiss Multi-Strategy Advisers LLC | 300,000 | 5,379,000 | 0.54% | ||
| 35 | Calamos Advisors LLC | 230,332 | 4,130,000 | 0.41% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 219,521 | 3,936,000 | 0.39% | ||
| 37 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 199,853 | 3,583,000 | 0.36% | ||
| 38 | Employees Retirement System of Texas | 198,000 | 3,550,000 | 0.35% | ||
| 39 | DEUTSCHE BANK AG\ | 176,339 | 3,161,000 | 0.31% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 175,766 | 3,152,000 | 0.31% | ||
| 41 | Skylands Capital, LLC | 170,500 | 3,057,000 | 0.30% | ||
| 42 | BlackRock Investment Management, LLC | 166,630 | 2,988,000 | 0.30% | ||
| 43 | MANAGED ACCOUNT ADVISORS LLC | 165,606 | 2,969,000 | 0.30% | ||
| 44 | NORGES BANK | 153,904 | 2,760,000 | 0.27% | ||
| 45 | CONTINENTAL ADVISORS LLC | 138,064 | 2,475,000 | 0.25% | ||
| 46 | RENAISSANCE TECHNOLOGIES LLC | 126,990 | 2,277,000 | 0.23% | ||
| 47 | PURA VIDA INVESTMENTS, LLC | 120,000 | 2,152,000 | 0.21% | ||
| 48 | D. E. Shaw & Co., Inc. | 115,217 | 2,066,000 | 0.21% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 113,899 | 2,042,000 | 0.20% | ||
| 50 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 106,800 | 2,017,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
