| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 6,318,050 | 99,636,000 | 10.59% | ||
| 2 | GILDER GAGNON HOWE & CO LLC | 5,184,950 | 81,767,000 | 8.69% | ||
| 3 | RS INVESTMENT MANAGEMENT CO LLC | 4,087,651 | 64,462,000 | 6.85% | ||
| 4 | VANGUARD GROUP INC | 3,881,090 | 61,204,000 | 6.50% | ||
| 5 | ORACLE INVESTMENT MANAGEMENT INC | 3,485,078 | 54,960,000 | 5.84% | ||
| 6 | FMR LLC | 2,610,300 | 41,164,000 | 4.37% | ||
| 7 | Cortina Asset Management, LLC | 2,210,671 | 34,862,000 | 3.71% | ||
| 8 | Tamarack Capital Management, LLC | 2,000,000 | 31,540,000 | 3.35% | ||
| 9 | BlackRock Fund Advisors | 1,652,531 | 26,060,000 | 2.77% | ||
| 10 | BANK OF MONTREAL /CAN/ | 1,625,570 | 25,636,000 | 2.72% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,586,203 | 25,014,000 | 2.66% | ||
| 12 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,369,584 | 21,598,000 | 2.30% | ||
| 13 | WELLS FARGO & COMPANY/MN | 1,362,021 | 21,480,000 | 2.28% | ||
| 14 | STATE STREET CORP | 1,145,281 | 18,065,000 | 1.92% | ||
| 15 | BROADVIEW ADVISORS LLC | 1,071,750 | 16,901,000 | 1.80% | ||
| 16 | JENNISON ASSOCIATES LLC | 1,049,780 | 16,555,000 | 1.76% | ||
| 17 | Point72 Asset Management, L.P. | 993,500 | 15,667,000 | 1.67% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 974,239 | 15,364,000 | 1.63% | ||
| 19 | BLAIR WILLIAM & CO/IL | 833,098 | 13,137,000 | 1.40% | ||
| 20 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 825,292 | 13,015,000 | 1.38% | ||
| 21 | NORTHERN TRUST CORP | 782,590 | 12,341,000 | 1.31% | ||
| 22 | Bank of New York Mellon Corp | 725,221 | 11,436,000 | 1.22% | ||
| 23 | OppenheimerFunds, Inc. | 713,575 | 11,253,000 | 1.20% | ||
| 24 | SECTORAL ASSET MANAGEMENT INC | 712,329 | 11,233,000 | 1.19% | ||
| 25 | TIVERTON ASSET MANAGEMENT LLC | 700,000 | 11,039,000 | 1.17% | ||
| 26 | CHARTWELL INVESTMENT PARTNERS, LLC | 683,520 | 10,779,000 | 1.15% | ||
| 27 | DEUTSCHE BANK AG\ | 659,961 | 10,406,000 | 1.11% | ||
| 28 | EverPoint Asset Management, LLC | 650,000 | 10,251,000 | 1.09% | ||
| 29 | Nuveen Asset Management, LLC | 465,790 | 7,345,000 | 0.78% | ||
| 30 | LORD, ABBETT & CO. LLC | 412,666 | 6,507,000 | 0.69% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 390,775 | 6,162,000 | 0.65% | ||
| 32 | DAFNA Capital Management LLC | 366,554 | 5,781,000 | 0.61% | SH | |
| 33 | PURA VIDA INVESTMENTS, LLC | 310,000 | 4,889,000 | 0.52% | ||
| 34 | PRUDENTIAL FINANCIAL INC | 307,792 | 4,854,000 | 0.52% | ||
| 35 | RENAISSANCE TECHNOLOGIES LLC | 295,490 | 4,660,000 | 0.50% | ||
| 36 | DECADE CAPITAL MANAGEMENT LLC | 280,000 | 4,416,000 | 0.47% | Call | |
| 37 | AMERIPRISE FINANCIAL INC | 276,581 | 4,362,000 | 0.46% | ||
| 38 | First Light Asset Management, LLC | 240,229 | 3,788,000 | 0.40% | ||
| 39 | TWO SIGMA ADVISERS, LP | 233,887 | 3,724,000 | 0.40% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 230,392 | 3,633,000 | 0.39% | ||
| 41 | Weiss Multi-Strategy Advisers LLC | 230,000 | 3,627,000 | 0.39% | ||
| 42 | D. E. Shaw & Co., Inc. | 221,758 | 3,497,000 | 0.37% | ||
| 43 | TWO SIGMA INVESTMENTS, LP | 212,373 | 3,349,000 | 0.36% | ||
| 44 | BlackRock Investment Management, LLC | 211,832 | 3,341,000 | 0.36% | ||
| 45 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 202,129 | 3,187,000 | 0.34% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 201,535 | 3,179,000 | 0.34% | ||
| 47 | Employees Retirement System of Texas | 198,000 | 3,122,000 | 0.33% | ||
| 48 | OXFORD ASSET MANAGEMENT LLP | 174,011 | 2,744,000 | 0.29% | ||
| 49 | GOLDMAN SACHS GROUP INC | 167,500 | 2,641,000 | 0.28% | Call | |
| 50 | Informed Momentum Co LLC | 149,065 | 2,351,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
