| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 9,271,307 | 231,690,000 | 14.51% | ||
| 2 | GILDER GAGNON HOWE & CO LLC | 5,890,709 | 147,209,000 | 9.22% | ||
| 3 | VANGUARD GROUP INC | 4,712,443 | 117,764,000 | 7.37% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,099,175 | 102,438,000 | 6.42% | ||
| 5 | ORACLE INVESTMENT MANAGEMENT INC | 2,671,936 | 66,772,000 | 4.18% | ||
| 6 | Invesco Ltd. | 2,526,489 | 63,137,000 | 3.95% | ||
| 7 | BlackRock Fund Advisors | 1,879,138 | 46,960,000 | 2.94% | ||
| 8 | VICTORY CAPITAL MANAGEMENT INC | 1,789,339 | 44,715,000 | 2.80% | ||
| 9 | PERCEPTIVE ADVISORS LLC | 1,669,703 | 41,726,000 | 2.61% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,660,469 | 41,495,000 | 2.60% | ||
| 11 | Cortina Asset Management, LLC | 1,482,206 | 37,040,000 | 2.32% | ||
| 12 | JENNISON ASSOCIATES LLC | 1,306,487 | 32,649,000 | 2.04% | ||
| 13 | WELLS FARGO & COMPANY/MN | 1,263,448 | 31,574,000 | 1.98% | ||
| 14 | SECTORAL ASSET MANAGEMENT INC | 1,199,869 | 29,985,000 | 1.88% | ||
| 15 | STATE STREET CORP | 1,182,341 | 29,541,000 | 1.85% | ||
| 16 | WADDELL & REED FINANCIAL INC | 1,086,769 | 27,159,000 | 1.70% | ||
| 17 | TAMARACK ADVISERS, LP | 1,075,000 | 26,617,000 | 1.67% | ||
| 18 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 974,417 | 24,351,000 | 1.52% | ||
| 19 | BLAIR WILLIAM & CO/IL | 857,861 | 21,438,000 | 1.34% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 848,415 | 21,202,000 | 1.33% | ||
| 21 | NORTHERN TRUST CORP | 823,968 | 20,591,000 | 1.29% | ||
| 22 | OppenheimerFunds, Inc. | 795,221 | 19,872,000 | 1.24% | ||
| 23 | Bank of New York Mellon Corp | 659,968 | 16,492,000 | 1.03% | ||
| 24 | Portolan Capital Management, LLC | 532,242 | 13,301,000 | 0.83% | ||
| 25 | GOLDMAN SACHS GROUP INC | 505,415 | 12,630,000 | 0.79% | ||
| 26 | BROADVIEW ADVISORS LLC | 502,606 | 12,560,000 | 0.79% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 489,623 | 12,235,000 | 0.77% | ||
| 28 | BANK OF MONTREAL /CAN/ | 473,456 | 11,832,000 | 0.74% | ||
| 29 | NORGES BANK | 487,358 | 11,632,000 | 0.73% | ||
| 30 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 451,031 | 11,271,000 | 0.71% | ||
| 31 | CHARTWELL INVESTMENT PARTNERS, LLC | 406,005 | 10,146,000 | 0.64% | ||
| 32 | Pennant Capital Management, LLC | 397,365 | 9,930,000 | 0.62% | ||
| 33 | COLUMBUS CIRCLE INVESTORS | 370,022 | 9,247,000 | 0.58% | ||
| 34 | TWO SIGMA INVESTMENTS, LP | 365,381 | 9,131,000 | 0.57% | ||
| 35 | PURA VIDA INVESTMENTS, LLC | 365,000 | 9,121,000 | 0.57% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 329,784 | 8,242,000 | 0.52% | ||
| 37 | PRUDENTIAL FINANCIAL INC | 326,896 | 8,169,000 | 0.51% | ||
| 38 | D. E. Shaw & Co., Inc. | 316,312 | 7,905,000 | 0.50% | ||
| 39 | Nuveen Asset Management, LLC | 290,470 | 7,259,000 | 0.45% | ||
| 40 | AMERIPRISE FINANCIAL INC | 285,805 | 7,143,000 | 0.45% | ||
| 41 | RENAISSANCE TECHNOLOGIES LLC | 250,983 | 6,272,000 | 0.39% | ||
| 42 | First Light Asset Management, LLC | 250,386 | 6,257,000 | 0.39% | ||
| 43 | BlackRock Investment Management, LLC | 238,833 | 5,968,000 | 0.37% | ||
| 44 | DAFNA Capital Management LLC | 238,509 | 5,960,000 | 0.37% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 234,872 | 5,869,000 | 0.37% | ||
| 46 | TWO SIGMA ADVISERS, LP | 224,087 | 5,600,000 | 0.35% | ||
| 47 | Pier Capital, LLC | 223,351 | 5,582,000 | 0.35% | ||
| 48 | Point72 Asset Management, L.P. | 200,000 | 4,998,000 | 0.31% | Call | |
| 49 | DELTA LLOYD NV | 175,000 | 4,373,000 | 0.27% | ||
| 50 | BLACKROCK ADVISORS LLC | 168,822 | 4,219,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
