| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | GILDER GAGNON HOWE & CO LLC | 6,048,014 | 90,660,000 | 9.83% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 5,506,028 | 82,535,000 | 8.95% | ||
| 3 | FMR LLC | 4,497,210 | 67,413,000 | 7.31% | ||
| 4 | VANGUARD GROUP INC | 4,124,080 | 61,820,000 | 6.70% | ||
| 5 | RS INVESTMENT MANAGEMENT CO LLC | 3,178,407 | 47,644,000 | 5.17% | ||
| 6 | ORACLE INVESTMENT MANAGEMENT INC | 2,694,636 | 40,393,000 | 4.38% | ||
| 7 | Invesco Ltd. | 2,283,392 | 34,228,000 | 3.71% | ||
| 8 | Cortina Asset Management, LLC | 2,034,300 | 30,494,000 | 3.31% | ||
| 9 | BlackRock Fund Advisors | 1,705,271 | 25,562,000 | 2.77% | ||
| 10 | JENNISON ASSOCIATES LLC | 1,704,610 | 25,552,000 | 2.77% | ||
| 11 | WELLS FARGO & COMPANY/MN | 1,702,998 | 25,528,000 | 2.77% | ||
| 12 | TAMARACK ADVISERS, LP | 1,700,000 | 25,483,000 | 2.76% | SH | |
| 13 | SECTORAL ASSET MANAGEMENT INC | 1,647,309 | 24,693,000 | 2.68% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 1,568,074 | 23,505,000 | 2.55% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 1,490,591 | 22,344,000 | 2.42% | ||
| 16 | BANK OF MONTREAL /CAN/ | 1,229,713 | 18,434,000 | 2.00% | ||
| 17 | STATE STREET CORP | 1,175,252 | 17,612,000 | 1.91% | ||
| 18 | BLAIR WILLIAM & CO/IL | 928,080 | 13,911,000 | 1.51% | ||
| 19 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 918,396 | 13,767,000 | 1.49% | ||
| 20 | NORTHERN TRUST CORP | 823,505 | 12,344,000 | 1.34% | ||
| 21 | OppenheimerFunds, Inc. | 760,144 | 11,395,000 | 1.24% | ||
| 22 | Bank of New York Mellon Corp | 735,206 | 11,020,000 | 1.20% | ||
| 23 | BROADVIEW ADVISORS LLC | 715,406 | 10,724,000 | 1.16% | ||
| 24 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 596,501 | 8,942,000 | 0.97% | ||
| 25 | CADIAN CAPITAL MANAGEMENT, LP | 483,450 | 7,247,000 | 0.79% | ||
| 26 | RENAISSANCE TECHNOLOGIES LLC | 478,783 | 7,177,000 | 0.78% | ||
| 27 | Allianz Asset Management GmbH | 455,249 | 6,824,000 | 0.74% | ||
| 28 | TWO SIGMA INVESTMENTS, LP | 454,356 | 6,811,000 | 0.74% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 407,776 | 6,112,000 | 0.66% | ||
| 30 | DAFNA Capital Management LLC | 396,554 | 5,944,000 | 0.64% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 392,989 | 5,891,000 | 0.64% | ||
| 32 | AMERIPRISE FINANCIAL INC | 364,462 | 5,462,000 | 0.59% | ||
| 33 | Nuveen Asset Management, LLC | 336,055 | 5,037,000 | 0.55% | ||
| 34 | Point72 Asset Management, L.P. | 325,000 | 4,872,000 | 0.53% | ||
| 35 | PRUDENTIAL FINANCIAL INC | 324,586 | 4,866,000 | 0.53% | ||
| 36 | TIVERTON ASSET MANAGEMENT LLC | 315,754 | 4,734,000 | 0.51% | ||
| 37 | NORGES BANK | 299,959 | 4,496,000 | 0.49% | ||
| 38 | D. E. Shaw & Co., Inc. | 283,346 | 4,247,000 | 0.46% | ||
| 39 | TWO SIGMA ADVISERS, LP | 273,287 | 4,097,000 | 0.44% | ||
| 40 | First Light Asset Management, LLC | 257,927 | 3,866,000 | 0.42% | ||
| 41 | CHARTWELL INVESTMENT PARTNERS, LLC | 255,480 | 3,830,000 | 0.42% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 240,863 | 3,611,000 | 0.39% | ||
| 43 | PURA VIDA INVESTMENTS, LLC | 240,157 | 3,600,000 | 0.39% | ||
| 44 | BlackRock Investment Management, LLC | 216,374 | 3,243,000 | 0.35% | ||
| 45 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 203,268 | 3,041,000 | 0.33% | ||
| 46 | Employees Retirement System of Texas | 198,000 | 2,968,000 | 0.32% | ||
| 47 | Weiss Multi-Strategy Advisers LLC | 196,960 | 2,952,000 | 0.32% | ||
| 48 | GFS Advisors, LLC | 39,529 | 2,637,000 | 0.29% | ||
| 49 | USCA RIA LLC | 39,529 | 2,637,000 | 0.29% | ||
| 50 | DELTA LLOYD NV | 175,000 | 2,623,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
