| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | GILDER GAGNON HOWE & CO LLC | 6,012,047 | 131,724,000 | 10.15% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,589,000 | 100,545,000 | 7.75% | ||
| 3 | VANGUARD GROUP INC | 3,997,151 | 87,578,000 | 6.75% | ||
| 4 | RS INVESTMENT MANAGEMENT CO LLC | 3,775,059 | 82,712,000 | 6.37% | ||
| 5 | FMR LLC | 3,320,583 | 72,754,000 | 5.61% | ||
| 6 | ORACLE INVESTMENT MANAGEMENT INC | 3,291,001 | 72,106,000 | 5.56% | ||
| 7 | Invesco Ltd. | 2,182,998 | 47,830,000 | 3.69% | ||
| 8 | Cortina Asset Management, LLC | 1,949,136 | 42,706,000 | 3.29% | ||
| 9 | TAMARACK ADVISERS, LP | 1,925,000 | 42,177,000 | 3.25% | ||
| 10 | BlackRock Fund Advisors | 1,723,227 | 37,756,000 | 2.91% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,573,091 | 34,466,000 | 2.66% | ||
| 12 | WELLS FARGO & COMPANY/MN | 1,450,307 | 31,777,000 | 2.45% | ||
| 13 | JENNISON ASSOCIATES LLC | 1,395,174 | 30,568,000 | 2.36% | ||
| 14 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,359,898 | 29,796,000 | 2.30% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 1,333,905 | 29,226,000 | 2.25% | ||
| 16 | BANK OF MONTREAL /CAN/ | 1,303,232 | 28,553,000 | 2.20% | ||
| 17 | STATE STREET CORP | 1,045,177 | 22,901,000 | 1.76% | ||
| 18 | BLAIR WILLIAM & CO/IL | 847,875 | 18,576,000 | 1.43% | ||
| 19 | NORTHERN TRUST CORP | 810,559 | 17,760,000 | 1.37% | ||
| 20 | BROADVIEW ADVISORS LLC | 809,180 | 17,729,000 | 1.37% | ||
| 21 | OppenheimerFunds, Inc. | 728,153 | 15,954,000 | 1.23% | ||
| 22 | SECTORAL ASSET MANAGEMENT INC | 701,303 | 15,366,000 | 1.18% | ||
| 23 | Bank of New York Mellon Corp | 700,979 | 15,358,000 | 1.18% | ||
| 24 | Point72 Asset Management, L.P. | 598,300 | 13,109,000 | 1.01% | ||
| 25 | CHARTWELL INVESTMENT PARTNERS, LLC | 570,630 | 12,503,000 | 0.96% | ||
| 26 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 553,548 | 12,128,000 | 0.93% | ||
| 27 | TIVERTON ASSET MANAGEMENT LLC | 475,000 | 10,407,000 | 0.80% | ||
| 28 | LORD, ABBETT & CO. LLC | 465,103 | 10,190,000 | 0.79% | ||
| 29 | TWO SIGMA INVESTMENTS, LP | 451,945 | 9,902,000 | 0.76% | ||
| 30 | CASTLEARK MANAGEMENT LLC | 403,440 | 8,839,000 | 0.68% | ||
| 31 | AMERIPRISE FINANCIAL INC | 393,698 | 8,627,000 | 0.66% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 393,422 | 8,619,000 | 0.66% | ||
| 33 | DAFNA Capital Management LLC | 366,554 | 8,031,000 | 0.62% | SH | |
| 34 | RENAISSANCE TECHNOLOGIES LLC | 361,990 | 7,931,000 | 0.61% | ||
| 35 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 305,189 | 6,686,000 | 0.52% | ||
| 36 | Nuveen Asset Management, LLC | 302,081 | 6,619,000 | 0.51% | ||
| 37 | D. E. Shaw & Co., Inc. | 278,688 | 6,106,000 | 0.47% | ||
| 38 | TWO SIGMA ADVISERS, LP | 269,421 | 5,903,000 | 0.45% | ||
| 39 | First Light Asset Management, LLC | 251,093 | 5,501,000 | 0.42% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 245,327 | 5,375,000 | 0.41% | ||
| 41 | PRUDENTIAL FINANCIAL INC | 245,086 | 5,369,000 | 0.41% | ||
| 42 | Weiss Multi-Strategy Advisers LLC | 230,000 | 5,039,000 | 0.39% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 223,013 | 4,887,000 | 0.38% | ||
| 44 | BlackRock Investment Management, LLC | 212,796 | 4,662,000 | 0.36% | ||
| 45 | PURA VIDA INVESTMENTS, LLC | 210,000 | 4,601,000 | 0.35% | ||
| 46 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 202,553 | 4,438,000 | 0.34% | ||
| 47 | GOLDMAN SACHS GROUP INC | 200,000 | 4,382,000 | 0.34% | Call | |
| 48 | Employees Retirement System of Texas | 198,000 | 4,338,000 | 0.33% | ||
| 49 | Informed Momentum Co LLC | 190,285 | 4,169,000 | 0.32% | ||
| 50 | KOPP INVESTMENT ADVISORS LLC | 169,612 | 3,716,000 | 0.29% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
