| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7,537,811 | 163,420,000 | 11.96% | ||
| 2 | GILDER GAGNON HOWE & CO LLC | 6,018,076 | 130,472,000 | 9.55% | ||
| 3 | VANGUARD GROUP INC | 4,602,539 | 99,783,000 | 7.30% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,505,468 | 97,679,000 | 7.15% | ||
| 5 | ORACLE INVESTMENT MANAGEMENT INC | 2,670,536 | 57,897,000 | 4.24% | ||
| 6 | Invesco Ltd. | 2,461,513 | 53,365,000 | 3.91% | ||
| 7 | RS INVESTMENT MANAGEMENT CO LLC | 2,154,390 | 46,707,000 | 3.42% | ||
| 8 | SECTORAL ASSET MANAGEMENT INC | 1,828,582 | 39,644,000 | 2.90% | ||
| 9 | BlackRock Fund Advisors | 1,821,951 | 39,500,000 | 2.89% | ||
| 10 | Cortina Asset Management, LLC | 1,717,194 | 37,229,000 | 2.72% | ||
| 11 | JENNISON ASSOCIATES LLC | 1,515,477 | 32,856,000 | 2.40% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,503,010 | 32,585,000 | 2.38% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 1,426,799 | 30,933,000 | 2.26% | ||
| 14 | PERCEPTIVE ADVISORS LLC | 1,382,410 | 29,971,000 | 2.19% | ||
| 15 | WELLS FARGO & COMPANY/MN | 1,340,652 | 29,066,000 | 2.13% | ||
| 16 | TAMARACK ADVISERS, LP | 1,200,000 | 26,016,000 | 1.90% | ||
| 17 | STATE STREET CORP | 1,043,728 | 22,629,000 | 1.66% | ||
| 18 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,017,605 | 22,062,000 | 1.61% | ||
| 19 | BLAIR WILLIAM & CO/IL | 1,186,242 | 19,598,000 | 1.43% | ||
| 20 | Consonance Capital Management LP | 835,134 | 18,106,000 | 1.33% | ||
| 21 | NORTHERN TRUST CORP | 825,463 | 17,895,000 | 1.31% | ||
| 22 | OppenheimerFunds, Inc. | 770,949 | 16,714,000 | 1.22% | ||
| 23 | Bank of New York Mellon Corp | 704,763 | 15,279,000 | 1.12% | ||
| 24 | BANK OF MONTREAL /CAN/ | 687,791 | 14,911,000 | 1.09% | ||
| 25 | BROADVIEW ADVISORS LLC | 602,306 | 13,058,000 | 0.96% | ||
| 26 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 591,298 | 12,819,000 | 0.94% | ||
| 27 | NORGES BANK | 533,258 | 11,561,000 | 0.85% | ||
| 28 | PRUDENTIAL FINANCIAL INC | 501,096 | 10,863,000 | 0.80% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 461,380 | 10,002,000 | 0.73% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 460,272 | 9,979,000 | 0.73% | ||
| 31 | Nuveen Asset Management, LLC | 453,683 | 9,836,000 | 0.72% | ||
| 32 | Polar Capital LLP | 375,194 | 8,134,000 | 0.60% | ||
| 33 | TWO SIGMA INVESTMENTS, LP | 367,069 | 7,958,000 | 0.58% | ||
| 34 | DAFNA Capital Management LLC | 356,509 | 7,729,000 | 0.57% | SH | |
| 35 | AMERIPRISE FINANCIAL INC | 332,926 | 7,219,000 | 0.53% | ||
| 36 | CHARTWELL INVESTMENT PARTNERS, LLC | 315,520 | 6,840,000 | 0.50% | ||
| 37 | LORD, ABBETT & CO. LLC | 259,467 | 5,625,000 | 0.41% | ||
| 38 | First Light Asset Management, LLC | 254,113 | 5,509,000 | 0.40% | ||
| 39 | TWO SIGMA ADVISERS, LP | 252,387 | 5,472,000 | 0.40% | ||
| 40 | D. E. Shaw & Co., Inc. | 244,348 | 5,297,000 | 0.39% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 239,148 | 5,185,000 | 0.38% | ||
| 42 | BlackRock Investment Management, LLC | 236,580 | 5,129,000 | 0.38% | ||
| 43 | WADDELL & REED FINANCIAL INC | 222,718 | 4,829,000 | 0.35% | ||
| 44 | Portolan Capital Management, LLC | 215,810 | 4,679,000 | 0.34% | ||
| 45 | COLUMBUS CIRCLE INVESTORS | 210,667 | 4,567,000 | 0.33% | ||
| 46 | MARSHALL WACE, LLP | 205,492 | 4,455,000 | 0.33% | ||
| 47 | PURA VIDA INVESTMENTS, LLC | 200,000 | 4,336,000 | 0.32% | ||
| 48 | Employees Retirement System of Texas | 198,000 | 4,293,000 | 0.31% | ||
| 49 | DELTA LLOYD NV | 175,000 | 3,794,000 | 0.28% | ||
| 50 | KOPP INVESTMENT ADVISORS LLC | 162,837 | 3,530,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
