| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 5,773,050 | 82,468,000 | 9.55% | ||
| 2 | GILDER GAGNON HOWE & CO LLC | 3,873,231 | 55,329,000 | 6.41% | ||
| 3 | VANGUARD GROUP INC | 3,748,705 | 53,551,000 | 6.20% | ||
| 4 | RS INVESTMENT MANAGEMENT CO LLC | 3,601,254 | 51,444,000 | 5.96% | ||
| 5 | ORACLE INVESTMENT MANAGEMENT INC | 3,572,963 | 51,040,000 | 5.91% | ||
| 6 | FMR LLC | 2,787,840 | 39,824,000 | 4.61% | ||
| 7 | Cortina Asset Management, LLC | 2,142,070 | 30,599,000 | 3.55% | ||
| 8 | CHARTWELL INVESTMENT PARTNERS, LLC | 1,845,654 | 26,365,000 | 3.05% | ||
| 9 | BlackRock Fund Advisors | 1,729,562 | 24,707,000 | 2.86% | ||
| 10 | BANK OF MONTREAL /CAN/ | 1,711,439 | 24,448,000 | 2.83% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,684,002 | 24,056,000 | 2.79% | ||
| 12 | Tamarack Capital Management, LLC | 1,675,000 | 23,927,000 | 2.77% | ||
| 13 | BLAIR WILLIAM & CO/IL | 1,465,214 | 20,930,000 | 2.42% | ||
| 14 | WELLS FARGO & COMPANY/MN | 1,414,803 | 20,211,000 | 2.34% | ||
| 15 | LORD, ABBETT & CO. LLC | 1,412,673 | 20,181,000 | 2.34% | ||
| 16 | Point72 Asset Management, L.P. | 1,269,600 | 18,136,000 | 2.10% | ||
| 17 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,249,709 | 17,852,093 | 2.07% | ||
| 18 | STATE STREET CORP | 1,218,362 | 17,410,000 | 2.02% | ||
| 19 | SECTORAL ASSET MANAGEMENT INC | 1,172,196 | 16,745,000 | 1.94% | ||
| 20 | BROADVIEW ADVISORS LLC | 1,065,825 | 15,225,000 | 1.76% | ||
| 21 | JENNISON ASSOCIATES LLC | 936,988 | 13,385,000 | 1.55% | ||
| 22 | EverPoint Asset Management, LLC | 800,000 | 11,428,000 | 1.32% | ||
| 23 | ALTRINSIC GLOBAL ADVISORS LLC | 746,300 | 10,661,000 | 1.24% | ||
| 24 | NORTHERN TRUST CORP | 725,383 | 10,362,000 | 1.20% | ||
| 25 | TIVERTON ASSET MANAGEMENT LLC | 700,000 | 10,000,000 | 1.16% | ||
| 26 | OppenheimerFunds, Inc. | 686,152 | 9,802,000 | 1.14% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 645,761 | 9,225,000 | 1.07% | ||
| 28 | Point72 Asset Management, L.P. | 600,000 | 8,571,000 | 0.99% | Call | |
| 29 | First Light Asset Management, LLC | 450,958 | 6,442,000 | 0.75% | ||
| 30 | TWO SIGMA INVESTMENTS, LP | 420,605 | 6,008,000 | 0.70% | ||
| 31 | Nuveen Asset Management, LLC | 411,680 | 5,881,000 | 0.68% | ||
| 32 | DEUTSCHE BANK AG\ | 381,357 | 5,446,000 | 0.63% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 374,146 | 5,344,000 | 0.62% | ||
| 34 | DAFNA Capital Management LLC | 366,554 | 5,236,000 | 0.61% | SH | |
| 35 | CITADEL ADVISORS LLC | 353,656 | 5,052,000 | 0.59% | ||
| 36 | Bank of New York Mellon Corp | 337,533 | 4,822,000 | 0.56% | ||
| 37 | Weiss Multi-Strategy Advisers LLC | 272,000 | 3,886,000 | 0.45% | ||
| 38 | PURA VIDA INVESTMENTS, LLC | 260,200 | 3,716,000 | 0.43% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 239,411 | 3,420,000 | 0.40% | ||
| 40 | DECADE CAPITAL MANAGEMENT LLC | 225,000 | 3,214,000 | 0.37% | Call | |
| 41 | GOLDMAN SACHS GROUP INC | 221,600 | 3,166,000 | 0.37% | Call | |
| 42 | D. E. Shaw & Co., Inc. | 218,996 | 3,128,000 | 0.36% | ||
| 43 | BlackRock Investment Management, LLC | 216,327 | 3,090,000 | 0.36% | ||
| 44 | TWO SIGMA ADVISERS, LP | 215,988 | 3,085,000 | 0.36% | ||
| 45 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 201,202 | 2,874,000 | 0.33% | ||
| 46 | Employees Retirement System of Texas | 198,000 | 2,828,000 | 0.33% | ||
| 47 | Skylands Capital, LLC | 190,226 | 2,718,000 | 0.31% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 189,332 | 2,705,000 | 0.31% | ||
| 49 | CLOUGH CAPITAL PARTNERS L P | 186,300 | 2,661,000 | 0.31% | ||
| 50 | CREDIT SUISSE AG/ | 161,676 | 2,309,000 | 0.27% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
