| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7,344,802 | 192,507,000 | 12.06% | ||
| 2 | GILDER GAGNON HOWE & CO LLC | 5,749,761 | 150,701,000 | 9.44% | ||
| 3 | VANGUARD GROUP INC | 4,861,529 | 127,420,000 | 7.98% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,258,196 | 111,607,000 | 6.99% | ||
| 5 | ORACLE INVESTMENT MANAGEMENT INC | 2,721,636 | 71,334,000 | 4.47% | ||
| 6 | Invesco Ltd. | 2,518,449 | 66,009,000 | 4.14% | ||
| 7 | BlackRock Fund Advisors | 2,081,973 | 54,569,000 | 3.42% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 1,927,989 | 50,533,000 | 3.17% | ||
| 9 | Pennant Capital Management, LLC | 1,927,408 | 50,517,000 | 3.16% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,730,076 | 45,345,000 | 2.84% | ||
| 11 | Cortina Asset Management, LLC | 1,367,027 | 35,830,000 | 2.24% | ||
| 12 | JENNISON ASSOCIATES LLC | 1,328,173 | 34,811,000 | 2.18% | ||
| 13 | VICTORY CAPITAL MANAGEMENT INC | 1,324,269 | 34,709,000 | 2.17% | ||
| 14 | WELLS FARGO & COMPANY/MN | 1,242,400 | 32,564,000 | 2.04% | ||
| 15 | STATE STREET CORP | 1,208,700 | 31,678,000 | 1.98% | ||
| 16 | WADDELL & REED FINANCIAL INC | 1,112,619 | 29,162,000 | 1.83% | ||
| 17 | SECTORAL ASSET MANAGEMENT INC | 891,313 | 23,361,000 | 1.46% | ||
| 18 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 842,552 | 22,083,000 | 1.38% | ||
| 19 | BLAIR WILLIAM & CO/IL | 831,476 | 21,793,000 | 1.37% | ||
| 20 | NORTHERN TRUST CORP | 831,312 | 21,789,000 | 1.37% | ||
| 21 | OppenheimerFunds, Inc. | 830,607 | 21,770,000 | 1.36% | ||
| 22 | Bank of New York Mellon Corp | 636,952 | 16,695,000 | 1.05% | ||
| 23 | Portolan Capital Management, LLC | 576,263 | 15,104,000 | 0.95% | ||
| 24 | NEXT CENTURY GROWTH INVESTORS LLC | 565,814 | 14,829,000 | 0.93% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 563,669 | 14,773,000 | 0.93% | ||
| 26 | BROADVIEW ADVISORS LLC | 507,156 | 13,293,000 | 0.83% | ||
| 27 | NORGES BANK | 451,758 | 11,841,000 | 0.74% | ||
| 28 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 444,156 | 11,641,000 | 0.73% | ||
| 29 | Polar Capital LLP | 400,000 | 10,484,000 | 0.66% | ||
| 30 | TAMARACK ADVISERS, LP | 367,690 | 9,637,000 | 0.60% | ||
| 31 | TWO SIGMA INVESTMENTS, LP | 320,232 | 8,393,000 | 0.53% | ||
| 32 | Nuveen Asset Management, LLC | 313,554 | 8,218,000 | 0.51% | ||
| 33 | D. E. Shaw & Co., Inc. | 295,494 | 7,745,000 | 0.49% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 289,547 | 7,589,000 | 0.48% | ||
| 35 | PRUDENTIAL FINANCIAL INC | 268,773 | 7,045,000 | 0.44% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 259,710 | 6,807,000 | 0.43% | ||
| 37 | PURA VIDA INVESTMENTS, LLC | 257,500 | 6,749,000 | 0.42% | ||
| 38 | MORGAN STANLEY | 251,353 | 6,588,000 | 0.41% | ||
| 39 | First Light Asset Management, LLC | 247,015 | 6,474,000 | 0.41% | ||
| 40 | BlackRock Investment Management, LLC | 238,118 | 6,241,000 | 0.39% | ||
| 41 | DAFNA Capital Management LLC | 236,119 | 6,189,000 | 0.39% | ||
| 42 | TWO SIGMA ADVISERS, LP | 228,287 | 5,983,000 | 0.37% | ||
| 43 | MARSHALL WACE, LLP | 228,002 | 5,976,000 | 0.37% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 223,285 | 5,852,000 | 0.37% | ||
| 45 | Pier Capital, LLC | 214,363 | 5,618,000 | 0.35% | ||
| 46 | BLACKROCK ADVISORS LLC | 193,987 | 5,084,000 | 0.32% | ||
| 47 | DELTA LLOYD NV | 175,000 | 4,587,000 | 0.29% | ||
| 48 | AMERIPRISE FINANCIAL INC | 171,867 | 4,505,000 | 0.28% | ||
| 49 | Rhenman & Partners Asset Management AB | 158,901 | 4,165,000 | 0.26% | ||
| 50 | LOOMIS SAYLES & CO L P | 152,166 | 3,988,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
