| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Consonance Capital Management LP | 3,024,851 | 27,163,000 | 13.13% | ||
| 2 | Broadfin Capital, LLC | 3,500,000 | 25,144,000 | 12.16% | ||
| 3 | Aisling Capital LLC | 2,010,000 | 18,050,000 | 8.73% | ||
| 4 | BANK OF MONTREAL /CAN/ | 1,285,763 | 11,546,000 | 5.58% | ||
| 5 | WALL STREET ASSOCIATES | 1,225,000 | 11,000,000 | 5.32% | ||
| 6 | ORBIMED ADVISORS LLC | 1,130,600 | 10,153,000 | 4.91% | ||
| 7 | JANUS HENDERSON INVESTORS US LLC | 864,469 | 7,763,000 | 3.75% | ||
| 8 | BlackRock Fund Advisors | 819,013 | 7,355,000 | 3.56% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 817,561 | 7,342,000 | 3.55% | ||
| 10 | KOPP INVESTMENT ADVISORS LLC | 634,753 | 5,701,000 | 2.76% | ||
| 11 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 572,760 | 5,143,000 | 2.49% | ||
| 12 | Allianz Asset Management GmbH | 562,746 | 5,053,000 | 2.44% | ||
| 13 | JUPITER ASSET MANAGEMENT LTD | 546,721 | 4,909,555 | 2.37% | ||
| 14 | VANGUARD GROUP INC | 516,284 | 4,636,000 | 2.24% | ||
| 15 | NORTHPOINTE CAPITAL LLC | 405,980 | 3,646,000 | 1.76% | ||
| 16 | Informed Momentum Co LLC | 399,784 | 3,590,000 | 1.74% | ||
| 17 | TFS CAPITAL LLC | 398,665 | 3,580,000 | 1.73% | ||
| 18 | GOLDMAN SACHS GROUP INC | 361,008 | 3,242,000 | 1.57% | ||
| 19 | KENNEDY CAPITAL MANAGEMENT LLC | 332,388 | 2,985,000 | 1.44% | ||
| 20 | Invesco Ltd. | 263,659 | 2,368,000 | 1.14% | ||
| 21 | STATE STREET CORP | 250,217 | 2,245,000 | 1.09% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 242,600 | 2,179,000 | 1.05% | Put | |
| 23 | COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 224,859 | 2,019,000 | 0.98% | ||
| 24 | DIMENSIONAL FUND ADVISORS LP | 211,843 | 1,902,000 | 0.92% | ||
| 25 | NORTHERN TRUST CORP | 188,781 | 1,696,000 | 0.82% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 171,477 | 1,540,000 | 0.74% | ||
| 27 | RENAISSANCE TECHNOLOGIES LLC | 157,637 | 1,416,000 | 0.68% | ||
| 28 | PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC | 157,000 | 1,410,000 | 0.68% | Call | |
| 29 | MILLENNIUM MANAGEMENT LLC | 154,377 | 1,386,000 | 0.67% | ||
| 30 | THOMPSON DAVIS & CO., INC. | 133,423 | 1,316,000 | 0.64% | ||
| 31 | EDMUNDS WHITE PARTNERS LLC | 124,779 | 1,121,000 | 0.54% | SH | |
| 32 | Bank of New York Mellon Corp | 117,923 | 1,059,000 | 0.51% | ||
| 33 | PANAGORA ASSET MANAGEMENT INC | 109,428 | 983,000 | 0.48% | ||
| 34 | ESSEX INVESTMENT MANAGEMENT CO LLC | 105,172 | 944,000 | 0.46% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 105,146 | 943,000 | 0.46% | ||
| 36 | GOLDMAN SACHS GROUP INC | 100,700 | 904,000 | 0.44% | Call | |
| 37 | GOLDMAN SACHS GROUP INC | 100,000 | 898,000 | 0.43% | Put | |
| 38 | BlackRock Investment Management, LLC | 95,943 | 862,000 | 0.42% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 95,143 | 854,000 | 0.41% | ||
| 40 | RUSSELL FRANK CO/ | 108,749 | 818,000 | 0.40% | ||
| 41 | ROYAL BANK OF CANADA | 89,713 | 806,000 | 0.39% | ||
| 42 | NOMURA HOLDINGS INC | 86,873 | 754,000 | 0.36% | ||
| 43 | JANE STREET GROUP, LLC | 61,841 | 555,000 | 0.27% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 60,778 | 546,000 | 0.26% | ||
| 45 | TWO SIGMA INVESTMENTS, LP | 56,890 | 511,000 | 0.25% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 48,800 | 439,000 | 0.21% | ||
| 47 | TEACHERS ADVISORS, LLC | 46,159 | 415,000 | 0.20% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 36,968 | 332,000 | 0.16% | ||
| 49 | MORGAN STANLEY | 32,970 | 296,000 | 0.14% | ||
| 50 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 29,740 | 267,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
