| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JANUS HENDERSON INVESTORS US LLC | 3,618,226 | 33,975,000 | 10.86% | ||
| 2 | Consonance Capital Management LP | 3,427,789 | 32,187,000 | 10.29% | ||
| 3 | Broadfin Capital, LLC | 3,050,000 | 28,640,000 | 9.16% | ||
| 4 | Aisling Capital LLC | 2,010,000 | 18,874,000 | 6.03% | ||
| 5 | KENNEDY CAPITAL MANAGEMENT LLC | 1,633,253 | 15,336,000 | 4.90% | ||
| 6 | BlackRock Fund Advisors | 1,381,348 | 12,971,000 | 4.15% | ||
| 7 | WALL STREET ASSOCIATES | 1,259,500 | 11,827,000 | 3.78% | ||
| 8 | Avoro Capital Advisors LLC | 1,134,578 | 10,654,000 | 3.41% | ||
| 9 | ORBIMED ADVISORS LLC | 1,073,000 | 10,075,000 | 3.22% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 972,614 | 9,133,000 | 2.92% | ||
| 11 | BANK OF MONTREAL /CAN/ | 864,340 | 8,116,000 | 2.59% | ||
| 12 | Cortina Asset Management, LLC | 839,030 | 7,878,000 | 2.52% | ||
| 13 | KOPP INVESTMENT ADVISORS LLC | 758,233 | 7,119,000 | 2.28% | ||
| 14 | CASTLEARK MANAGEMENT LLC | 722,709 | 6,786,000 | 2.17% | ||
| 15 | VANGUARD GROUP INC | 693,146 | 6,508,000 | 2.08% | ||
| 16 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 683,756 | 6,420,000 | 2.05% | ||
| 17 | ACUTA CAPITAL PARTNERS, LLC | 604,075 | 5,672,000 | 1.81% | ||
| 18 | Allianz Asset Management GmbH | 545,839 | 5,125,000 | 1.64% | ||
| 19 | Informed Momentum Co LLC | 501,598 | 4,710,000 | 1.51% | ||
| 20 | Elk Creek Partners, LLC | 474,498 | 4,456,000 | 1.42% | ||
| 21 | ALYDAR PARTNERS LLC | 410,000 | 3,850,000 | 1.23% | ||
| 22 | STATE STREET CORP | 402,738 | 3,784,000 | 1.21% | ||
| 23 | WELLS FARGO & COMPANY/MN | 376,924 | 3,539,000 | 1.13% | ||
| 24 | JUPITER ASSET MANAGEMENT LTD | 358,521 | 3,366,512 | 1.08% | ||
| 25 | NORTHERN TRUST CORP | 340,083 | 3,193,000 | 1.02% | ||
| 26 | RUDMAN ERROL M | 300,000 | 2,817,000 | 0.90% | ||
| 27 | Timpani Capital Management LLC | 291,377 | 2,736,000 | 0.87% | ||
| 28 | AQR CAPITAL MANAGEMENT LLC | 265,055 | 2,489,000 | 0.80% | ||
| 29 | Bank of New York Mellon Corp | 221,303 | 2,078,000 | 0.66% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 219,267 | 2,059,000 | 0.66% | ||
| 31 | DIMENSIONAL FUND ADVISORS LP | 218,821 | 2,055,000 | 0.66% | ||
| 32 | DRIEHAUS CAPITAL MANAGEMENT LLC | 215,393 | 2,023,000 | 0.65% | ||
| 33 | RUSSELL FRANK CO/ | 187,672 | 1,768,000 | 0.57% | ||
| 34 | AMERIPRISE FINANCIAL INC | 173,654 | 1,630,000 | 0.52% | ||
| 35 | Century Capital Management, LLC | 172,596 | 1,621,000 | 0.52% | ||
| 36 | GEODE CAPITAL MANAGEMENT, LLC | 157,073 | 1,474,000 | 0.47% | ||
| 37 | THOMPSON DAVIS & CO., INC. | 154,760 | 1,453,000 | 0.46% | ||
| 38 | MILLENNIUM MANAGEMENT LLC | 149,074 | 1,400,000 | 0.45% | ||
| 39 | Coe Capital Management, LLC | 139,682 | 1,311,614 | 0.42% | ||
| 40 | ESSEX INVESTMENT MANAGEMENT CO LLC | 134,800 | 1,266,000 | 0.40% | ||
| 41 | PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC | 118,600 | 1,114,000 | 0.36% | Put | |
| 42 | JW Asset Management, LLC | 112,160 | 1,054,000 | 0.34% | ||
| 43 | CITADEL ADVISORS LLC | 111,738 | 1,050,000 | 0.34% | ||
| 44 | CREDIT SUISSE AG/ | 111,489 | 1,047,000 | 0.33% | ||
| 45 | DEUTSCHE BANK AG\ | 109,189 | 1,024,000 | 0.33% | ||
| 46 | PERKINS CAPITAL MANAGEMENT INC | 105,800 | 993,000 | 0.32% | ||
| 47 | NORTHPOINTE CAPITAL LLC | 101,686 | 955,000 | 0.31% | ||
| 48 | GROW Partners, LLC | 100,000 | 939,000 | 0.30% | ||
| 49 | BlackRock Investment Management, LLC | 96,152 | 903,000 | 0.29% | ||
| 50 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 82,200 | 772,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
