| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 6,090,829 | 19,247,000 | 14.19% | ||
| 2 | Avoro Capital Advisors LLC | 6,004,564 | 18,974,000 | 13.99% | ||
| 3 | ARMISTICE CAPITAL, LLC | 4,800,000 | 15,168,000 | 11.19% | ||
| 4 | BlackRock Fund Advisors | 2,014,955 | 6,367,000 | 4.70% | ||
| 5 | Aisling Capital LLC | 2,010,000 | 6,352,000 | 4.68% | ||
| 6 | Elk Creek Partners, LLC | 1,864,515 | 5,892,000 | 4.34% | ||
| 7 | VANGUARD GROUP INC | 1,739,845 | 5,498,000 | 4.05% | ||
| 8 | TFS CAPITAL LLC | 1,313,072 | 4,149,000 | 3.06% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,131,074 | 3,574,000 | 2.64% | ||
| 10 | ACUTA CAPITAL PARTNERS, LLC | 1,108,719 | 3,504,000 | 2.58% | ||
| 11 | ORBIMED ADVISORS LLC | 1,073,000 | 3,391,000 | 2.50% | ||
| 12 | Point72 Asset Management, L.P. | 1,050,005 | 3,318,000 | 2.45% | ||
| 13 | JUPITER ASSET MANAGEMENT LTD | 908,713 | 2,872,000 | 2.12% | ||
| 14 | BANK OF MONTREAL /CAN/ | 808,447 | 2,555,000 | 1.88% | ||
| 15 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 799,145 | 2,526,000 | 1.86% | ||
| 16 | WALL STREET ASSOCIATES | 696,300 | 2,200,000 | 1.62% | ||
| 17 | DG Capital Management, LLC | 695,808 | 2,199,000 | 1.62% | ||
| 18 | KENNEDY CAPITAL MANAGEMENT LLC | 608,473 | 1,923,000 | 1.42% | ||
| 19 | RK Capital Management, LLC | 601,817 | 1,902,000 | 1.40% | ||
| 20 | STATE STREET CORP | 537,179 | 1,695,000 | 1.25% | ||
| 21 | RENAISSANCE TECHNOLOGIES LLC | 463,602 | 1,465,000 | 1.08% | ||
| 22 | NORTHERN TRUST CORP | 458,060 | 1,447,000 | 1.07% | ||
| 23 | AQR CAPITAL MANAGEMENT LLC | 432,466 | 1,366,000 | 1.01% | ||
| 24 | AMERIPRISE FINANCIAL INC | 405,250 | 1,279,000 | 0.94% | ||
| 25 | KOPP INVESTMENT ADVISORS LLC | 375,293 | 1,186,000 | 0.87% | ||
| 26 | Rotella Capital Management, Inc. | 366,920 | 1,159,000 | 0.85% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 347,835 | 1,099,000 | 0.81% | ||
| 28 | TURNER INVESTMENTS LLC | 325,990 | 1,030,000 | 0.76% | ||
| 29 | GLOBEFLEX CAPITAL L P | 251,014 | 793,000 | 0.58% | ||
| 30 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 233,856 | 739,000 | 0.54% | ||
| 31 | DIMENSIONAL FUND ADVISORS LP | 228,072 | 721,000 | 0.53% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 225,253 | 711,000 | 0.52% | ||
| 33 | SEARLE & CO. | 172,500 | 545,000 | 0.40% | ||
| 34 | DEUTSCHE BANK AG\ | 165,090 | 520,000 | 0.38% | ||
| 35 | BlackRock Investment Management, LLC | 156,541 | 495,000 | 0.37% | ||
| 36 | Bank of New York Mellon Corp | 156,109 | 493,000 | 0.36% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 144,601 | 457,000 | 0.34% | ||
| 38 | Connor, Clark & Lunn Investment Management Ltd. | 141,750 | 448,000 | 0.33% | ||
| 39 | BLACKROCK ADVISORS LLC | 119,883 | 379,000 | 0.28% | ||
| 40 | PANAGORA ASSET MANAGEMENT INC | 108,148 | 342,000 | 0.25% | ||
| 41 | ESSEX INVESTMENT MANAGEMENT CO LLC | 84,089 | 266,000 | 0.20% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 79,220 | 250,000 | 0.18% | ||
| 43 | STEVENS CAPITAL MANAGEMENT LP | 77,513 | 245,000 | 0.18% | ||
| 44 | PALISADE CAPITAL MANAGEMENT, LP | 73,000 | 231,000 | 0.17% | ||
| 45 | TEACHERS ADVISORS, LLC | 67,466 | 213,000 | 0.16% | ||
| 46 | JW Asset Management, LLC | 67,009 | 212,000 | 0.16% | ||
| 47 | UBS Group AG | 64,900 | 205,000 | 0.15% | ||
| 48 | Polaris Capital Management, LLC | 56,983 | 180,000 | 0.13% | ||
| 49 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 56,175 | 177,000 | 0.13% | ||
| 50 | ProShare Advisors LLC | 50,709 | 160,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
