| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 6,090,829 | 17,968,000 | 14.02% | ||
| 2 | MORGAN STANLEY | 5,160,043 | 15,222,000 | 11.88% | ||
| 3 | Avoro Capital Advisors LLC | 5,144,916 | 15,178,000 | 11.85% | ||
| 4 | STONEPINE CAPITAL MANAGEMENT, LLC | 2,484,649 | 7,330,000 | 5.72% | ||
| 5 | Elk Creek Partners, LLC | 2,253,667 | 6,648,000 | 5.19% | ||
| 6 | Aisling Capital LLC | 2,010,000 | 5,930,000 | 4.63% | ||
| 7 | VANGUARD GROUP INC | 1,790,106 | 5,281,000 | 4.12% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 1,290,434 | 3,807,000 | 2.97% | ||
| 9 | BlackRock Fund Advisors | 1,181,604 | 3,486,000 | 2.72% | ||
| 10 | ORBIMED ADVISORS LLC | 1,073,000 | 3,165,000 | 2.47% | ||
| 11 | Point72 Asset Management, L.P. | 1,050,005 | 3,098,000 | 2.42% | ||
| 12 | BANK OF MONTREAL /CAN/ | 1,045,279 | 3,083,000 | 2.41% | ||
| 13 | AQR CAPITAL MANAGEMENT LLC | 912,196 | 2,691,000 | 2.10% | ||
| 14 | TFS CAPITAL LLC | 909,616 | 2,683,000 | 2.09% | ||
| 15 | JUPITER ASSET MANAGEMENT LTD | 908,713 | 2,681,000 | 2.09% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 872,636 | 2,574,000 | 2.01% | ||
| 17 | RENAISSANCE TECHNOLOGIES LLC | 847,823 | 2,501,000 | 1.95% | ||
| 18 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 799,145 | 2,358,000 | 1.84% | ||
| 19 | WALL STREET ASSOCIATES | 696,300 | 2,054,000 | 1.60% | ||
| 20 | STATE STREET CORP | 535,201 | 1,582,000 | 1.23% | ||
| 21 | NORTHERN TRUST CORP | 454,962 | 1,342,000 | 1.05% | ||
| 22 | ACUTA CAPITAL PARTNERS, LLC | 434,300 | 1,281,000 | 1.00% | ||
| 23 | AMERIPRISE FINANCIAL INC | 409,705 | 1,208,000 | 0.94% | ||
| 24 | ACADIAN ASSET MANAGEMENT LLC | 328,213 | 968,000 | 0.76% | ||
| 25 | KOPP INVESTMENT ADVISORS LLC | 315,293 | 931,000 | 0.73% | ||
| 26 | PANAGORA ASSET MANAGEMENT INC | 283,524 | 836,000 | 0.65% | ||
| 27 | D. E. Shaw & Co., Inc. | 246,637 | 728,000 | 0.57% | ||
| 28 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 237,456 | 701,000 | 0.55% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 232,018 | 683,000 | 0.53% | ||
| 30 | DIMENSIONAL FUND ADVISORS LP | 229,792 | 678,000 | 0.53% | ||
| 31 | Connor, Clark & Lunn Investment Management Ltd. | 196,700 | 580,000 | 0.45% | ||
| 32 | GLOBEFLEX CAPITAL L P | 192,267 | 567,000 | 0.44% | ||
| 33 | Bank of New York Mellon Corp | 178,444 | 526,000 | 0.41% | ||
| 34 | SEARLE & CO. | 172,500 | 500,000 | 0.39% | ||
| 35 | BlackRock Investment Management, LLC | 156,940 | 463,000 | 0.36% | ||
| 36 | Healthcare Value Capital, LLC | 150,000 | 443,000 | 0.35% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 144,601 | 427,000 | 0.33% | ||
| 38 | BLACKROCK ADVISORS LLC | 122,050 | 360,000 | 0.28% | ||
| 39 | DEUTSCHE BANK AG\ | 117,070 | 344,000 | 0.27% | ||
| 40 | GOLDMAN SACHS GROUP INC | 115,608 | 341,000 | 0.27% | ||
| 41 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 106,544 | 314,000 | 0.25% | ||
| 42 | EAGLE GLOBAL ADVISORS LLC | 101,360 | 299,000 | 0.23% | ||
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 80,706 | 238,000 | 0.19% | ||
| 44 | ESSEX INVESTMENT MANAGEMENT CO LLC | 78,629 | 232,000 | 0.18% | ||
| 45 | TEACHERS ADVISORS, LLC | 67,466 | 199,000 | 0.16% | ||
| 46 | JW Asset Management, LLC | 67,009 | 198,000 | 0.15% | ||
| 47 | STEVENS CAPITAL MANAGEMENT LP | 59,957 | 177,000 | 0.14% | ||
| 48 | MENTA CAPITAL LLC | 55,000 | 162,000 | 0.13% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 47,618 | 150,000 | 0.12% | ||
| 50 | Parallax Volatility Advisers, L.P. | 50,000 | 148,000 | 0.12% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
