| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JANUS HENDERSON INVESTORS US LLC | 3,585,131 | 27,534,000 | 13.51% | ||
| 2 | Broadfin Capital, LLC | 3,500,000 | 26,880,000 | 13.19% | ||
| 3 | Consonance Capital Management LP | 3,443,137 | 26,443,000 | 12.97% | ||
| 4 | Aisling Capital LLC | 2,010,000 | 15,440,000 | 7.58% | ||
| 5 | BANK OF MONTREAL /CAN/ | 1,340,470 | 10,295,000 | 5.05% | ||
| 6 | WALL STREET ASSOCIATES | 1,161,700 | 8,922,000 | 4.38% | ||
| 7 | ORBIMED ADVISORS LLC | 1,073,000 | 8,241,000 | 4.04% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 945,252 | 7,260,000 | 3.56% | ||
| 9 | KOPP INVESTMENT ADVISORS LLC | 794,658 | 6,103,000 | 2.99% | ||
| 10 | BlackRock Fund Advisors | 793,867 | 6,097,000 | 2.99% | ||
| 11 | KENNEDY CAPITAL MANAGEMENT LLC | 648,551 | 4,981,000 | 2.44% | ||
| 12 | VANGUARD GROUP INC | 626,703 | 4,813,000 | 2.36% | ||
| 13 | JUPITER ASSET MANAGEMENT LTD | 553,921 | 4,254,000 | 2.09% | ||
| 14 | Allianz Asset Management GmbH | 551,900 | 4,239,000 | 2.08% | ||
| 15 | NORTHERN TRUST CORP | 353,864 | 2,717,000 | 1.33% | ||
| 16 | Informed Momentum Co LLC | 319,988 | 2,458,000 | 1.21% | ||
| 17 | Elk Creek Partners, LLC | 290,720 | 2,233,000 | 1.10% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 285,880 | 2,196,000 | 1.08% | ||
| 19 | THOMPSON DAVIS & CO., INC. | 276,633 | 2,125,000 | 1.04% | ||
| 20 | AQR CAPITAL MANAGEMENT LLC | 270,400 | 2,077,000 | 1.02% | ||
| 21 | STATE STREET CORP | 266,533 | 2,047,000 | 1.00% | ||
| 22 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 252,960 | 1,942,000 | 0.95% | ||
| 23 | Invesco Ltd. | 234,744 | 1,802,000 | 0.88% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 222,311 | 1,707,000 | 0.84% | ||
| 25 | DIMENSIONAL FUND ADVISORS LP | 218,821 | 1,681,000 | 0.82% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 184,600 | 1,418,000 | 0.70% | Put | |
| 27 | NORTHPOINTE CAPITAL LLC | 175,261 | 1,346,000 | 0.66% | ||
| 28 | GOLDMAN SACHS GROUP INC | 164,564 | 1,264,000 | 0.62% | ||
| 29 | Bank of New York Mellon Corp | 154,554 | 1,187,000 | 0.58% | ||
| 30 | CADENCE CAPITAL MANAGEMENT LLC | 138,470 | 1,063,000 | 0.52% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 137,901 | 1,059,000 | 0.52% | ||
| 32 | RENAISSANCE TECHNOLOGIES LLC | 100,837 | 774,000 | 0.38% | ||
| 33 | RUDMAN ERROL M | 100,000 | 768,000 | 0.38% | ||
| 34 | ESSEX INVESTMENT MANAGEMENT CO LLC | 98,045 | 753,000 | 0.37% | ||
| 35 | BlackRock Investment Management, LLC | 97,327 | 747,000 | 0.37% | ||
| 36 | TFS CAPITAL LLC | 95,421 | 733,000 | 0.36% | ||
| 37 | RUSSELL FRANK CO/ | 85,893 | 660,000 | 0.32% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 65,900 | 506,000 | 0.25% | Call | |
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 61,427 | 472,000 | 0.23% | ||
| 40 | Potomac Capital Management, Inc. | 49,000 | 376,000 | 0.18% | ||
| 41 | PANAGORA ASSET MANAGEMENT INC | 48,968 | 376,000 | 0.18% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 48,800 | 375,000 | 0.18% | ||
| 43 | CREDIT SUISSE AG/ | 48,737 | 374,000 | 0.18% | ||
| 44 | DEUTSCHE BANK AG\ | 46,652 | 357,000 | 0.18% | ||
| 45 | TEACHERS ADVISORS, LLC | 46,159 | 355,000 | 0.17% | ||
| 46 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 44,500 | 342,000 | 0.17% | ||
| 47 | PRELUDE CAPITAL MANAGEMENT, LLC | 40,400 | 310,000 | 0.15% | ||
| 48 | UBS AG | 33,000 | 253,000 | 0.12% | ||
| 49 | D. E. Shaw & Co., Inc. | 28,970 | 222,000 | 0.11% | ||
| 50 | Nationwide Fund Advisors | 28,053 | 215,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
