| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JANUS HENDERSON INVESTORS US LLC | 3,954,885 | 42,278,000 | 10.89% | ||
| 2 | Consonance Capital Management LP | 3,261,484 | 34,865,000 | 8.98% | ||
| 3 | Broadfin Capital, LLC | 2,168,326 | 23,179,000 | 5.97% | ||
| 4 | Aisling Capital LLC | 2,010,000 | 21,487,000 | 5.53% | ||
| 5 | KENNEDY CAPITAL MANAGEMENT LLC | 1,668,152 | 17,833,000 | 4.59% | ||
| 6 | BlackRock Fund Advisors | 1,410,141 | 15,074,000 | 3.88% | ||
| 7 | Avoro Capital Advisors LLC | 1,395,167 | 14,914,000 | 3.84% | ||
| 8 | WALL STREET ASSOCIATES | 1,237,000 | 13,224,000 | 3.41% | ||
| 9 | Allianz Asset Management GmbH | 1,106,994 | 11,834,000 | 3.05% | ||
| 10 | RK Capital Management, LLC | 1,076,200 | 11,505,000 | 2.96% | ||
| 11 | ORBIMED ADVISORS LLC | 1,073,000 | 11,470,000 | 2.95% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,042,145 | 11,141,000 | 2.87% | ||
| 13 | Cortina Asset Management, LLC | 993,194 | 10,617,000 | 2.73% | ||
| 14 | Elk Creek Partners, LLC | 978,609 | 10,461,000 | 2.69% | ||
| 15 | VANGUARD GROUP INC | 856,759 | 9,158,000 | 2.36% | ||
| 16 | BANK OF MONTREAL /CAN/ | 817,485 | 8,739,000 | 2.25% | ||
| 17 | KOPP INVESTMENT ADVISORS LLC | 720,553 | 7,703,000 | 1.98% | ||
| 18 | RUDMAN ERROL M | 630,900 | 6,744,000 | 1.74% | ||
| 19 | PUTNAM INVESTMENTS LLC | 536,800 | 5,739,000 | 1.48% | ||
| 20 | CASTLEARK MANAGEMENT LLC | 515,677 | 5,513,000 | 1.42% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 459,934 | 4,917,000 | 1.27% | ||
| 22 | WELLS FARGO & COMPANY/MN | 445,199 | 4,759,000 | 1.23% | ||
| 23 | STATE STREET CORP | 444,799 | 4,754,000 | 1.22% | ||
| 24 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 439,291 | 4,696,000 | 1.21% | ||
| 25 | Timpani Capital Management LLC | 371,516 | 3,972,000 | 1.02% | ||
| 26 | JUPITER ASSET MANAGEMENT LTD | 359,278 | 3,841,000 | 0.99% | ||
| 27 | Nicholas Investment Partners, LP | 358,482 | 3,832,000 | 0.99% | ||
| 28 | ACUTA CAPITAL PARTNERS, LLC | 350,000 | 3,742,000 | 0.96% | ||
| 29 | NORTHERN TRUST CORP | 342,362 | 3,660,000 | 0.94% | ||
| 30 | DRIEHAUS CAPITAL MANAGEMENT LLC | 299,786 | 3,205,000 | 0.83% | ||
| 31 | Ghost Tree Capital, LLC | 250,000 | 2,673,000 | 0.69% | ||
| 32 | ICON ADVISERS INC/CO | 244,686 | 2,616,000 | 0.67% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 236,144 | 2,525,000 | 0.65% | ||
| 34 | Bank of New York Mellon Corp | 228,058 | 2,438,000 | 0.63% | ||
| 35 | DIMENSIONAL FUND ADVISORS LP | 212,352 | 2,270,000 | 0.58% | ||
| 36 | Invesco Ltd. | 185,565 | 1,984,000 | 0.51% | ||
| 37 | TFS CAPITAL LLC | 183,614 | 1,963,000 | 0.51% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 181,474 | 1,939,000 | 0.50% | ||
| 39 | CITADEL ADVISORS LLC | 179,905 | 1,924,000 | 0.50% | ||
| 40 | THOMPSON DAVIS & CO., INC. | 171,074 | 1,829,000 | 0.47% | ||
| 41 | NORTHPOINTE CAPITAL LLC | 169,066 | 1,807,000 | 0.47% | ||
| 42 | TWO SIGMA INVESTMENTS, LP | 167,290 | 1,788,000 | 0.46% | ||
| 43 | Nationwide Fund Advisors | 137,433 | 1,469,000 | 0.38% | ||
| 44 | AQR CAPITAL MANAGEMENT LLC | 115,855 | 1,238,000 | 0.32% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 112,171 | 1,199,000 | 0.31% | ||
| 46 | Trexquant Investment LP | 111,000 | 1,186,000 | 0.31% | ||
| 47 | PDT Partners, LLC | 105,939 | 1,132,000 | 0.29% | ||
| 48 | JW Asset Management, LLC | 101,671 | 1,087,000 | 0.28% | ||
| 49 | BlackRock Investment Management, LLC | 96,455 | 1,031,000 | 0.27% | ||
| 50 | DEUTSCHE BANK AG\ | 96,267 | 1,028,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
