| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7,671,981 | 162,262,000 | 20.23% | ||
| 2 | Kohlberg Kravis Roberts & Co. L.P. | 3,055,055 | 64,614,000 | 8.05% | ||
| 3 | BlackRock Finance, Inc. | 2,844,827 | 60,168,000 | 7.50% | ||
| 4 | VANGUARD GROUP INC | 2,209,244 | 46,726,000 | 5.82% | ||
| 5 | JPMORGAN CHASE & CO | 1,630,487 | 34,485,000 | 4.30% | ||
| 6 | PFM Health Sciences, LP | 1,499,682 | 31,718,000 | 3.95% | ||
| 7 | WELLINGTON MANAGEMENT GROUP LLP | 1,268,479 | 26,829,000 | 3.34% | ||
| 8 | Carlson Capital, L.P. | 1,206,801 | 25,524,000 | 3.18% | ||
| 9 | STATE STREET CORP | 1,117,586 | 23,638,000 | 2.95% | ||
| 10 | ORBIMED ADVISORS LLC | 1,084,400 | 22,935,000 | 2.86% | ||
| 11 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 900,317 | 19,041,706 | 2.37% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 806,346 | 17,054,000 | 2.13% | ||
| 13 | JHL Capital Group LLC | 700,000 | 14,805,000 | 1.85% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 696,149 | 14,724,000 | 1.84% | ||
| 15 | Rock Springs Capital Management LP | 675,000 | 14,276,000 | 1.78% | ||
| 16 | Cormorant Asset Management, LP | 620,300 | 13,119,000 | 1.64% | ||
| 17 | TIAA CREF INVESTMENT MANAGEMENT LLC | 586,875 | 12,412,000 | 1.55% | ||
| 18 | BROWN ADVISORY INC | 451,536 | 9,550,000 | 1.19% | ||
| 19 | Alyeska Investment Group, L.P. | 450,000 | 9,518,000 | 1.19% | ||
| 20 | PICTET ASSET MANAGEMENT LTD | 441,788 | 9,344,000 | 1.16% | ||
| 21 | PointState Capital LP | 421,300 | 8,910,000 | 1.11% | ||
| 22 | NORTHERN TRUST CORP | 407,934 | 8,628,000 | 1.08% | ||
| 23 | HIGHLAND CAPITAL MANAGEMENT LP | 378,230 | 8,000,000 | 1.00% | ||
| 24 | AXA S.A. | 368,752 | 7,799,000 | 0.97% | ||
| 25 | AMERIPRISE FINANCIAL INC | 331,492 | 7,011,000 | 0.87% | ||
| 26 | BRIDGER MANAGEMENT, LLC | 329,345 | 6,966,000 | 0.87% | ||
| 27 | D. E. Shaw & Co., Inc. | 319,470 | 6,757,000 | 0.84% | ||
| 28 | Candriam S.C.A. | 288,000 | 6,091,000 | 0.76% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 272,749 | 5,768,000 | 0.72% | ||
| 30 | JET CAPITAL INVESTORS L P | 250,000 | 5,288,000 | 0.66% | Call | |
| 31 | LORD, ABBETT & CO. LLC | 229,392 | 4,852,000 | 0.60% | ||
| 32 | COLUMBUS CIRCLE INVESTORS | 222,973 | 4,716,000 | 0.59% | ||
| 33 | TEACHERS ADVISORS, LLC | 219,671 | 4,646,000 | 0.58% | ||
| 34 | C WorldWide Group Holding A/S | 192,887 | 4,080,000 | 0.51% | ||
| 35 | Allianz Asset Management GmbH | 189,745 | 3,975,000 | 0.50% | ||
| 36 | BELLEVUE GROUP AG | 175,000 | 3,701,000 | 0.46% | ||
| 37 | Bank of New York Mellon Corp | 165,140 | 3,492,000 | 0.44% | ||
| 38 | CREDIT SUISSE AG/ | 164,113 | 3,472,000 | 0.43% | ||
| 39 | EVENTIDE ASSET MANAGEMENT, LLC | 145,000 | 3,067,000 | 0.38% | ||
| 40 | CITADEL ADVISORS LLC | 144,667 | 3,060,000 | 0.38% | ||
| 41 | GOLDMAN SACHS GROUP INC | 141,095 | 2,984,000 | 0.37% | ||
| 42 | PRINCIPAL FINANCIAL GROUP INC | 138,440 | 2,928,000 | 0.36% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 134,302 | 2,841,000 | 0.35% | ||
| 44 | Spark Investment Management LLC | 124,900 | 2,641,000 | 0.33% | ||
| 45 | KENNEDY CAPITAL MANAGEMENT LLC | 122,894 | 2,599,000 | 0.32% | ||
| 46 | RENAISSANCE TECHNOLOGIES LLC | 113,200 | 2,394,000 | 0.30% | ||
| 47 | Rhenman & Partners Asset Management AB | 111,357 | 2,355,000 | 0.29% | ||
| 48 | VHCP MANAGEMENT II, LLC | 95,276 | 2,015,000 | 0.25% | ||
| 49 | SABBY MANAGEMENT, LLC | 93,308 | 1,973,000 | 0.25% | ||
| 50 | Tekla Capital Management LLC | 90,000 | 1,904,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
