| 1 |
FMR LLC |
3,236,136 |
58,607,000 |
28.66% |
|
|
| 2 |
Canaan Partners VII LLC |
2,500,149 |
45,277,000 |
22.14% |
|
|
| 3 |
Aisling Capital LLC |
1,102,046 |
19,958,000 |
9.76% |
|
|
| 4 |
JENNISON ASSOCIATES LLC |
523,978 |
9,489,000 |
4.64% |
|
|
| 5 |
FRANKLIN RESOURCES INC |
407,600 |
7,382,000 |
3.61% |
|
|
| 6 |
SABBY MANAGEMENT, LLC |
352,088 |
6,376,000 |
3.12% |
|
|
| 7 |
VANGUARD GROUP INC |
294,533 |
5,334,000 |
2.61% |
|
|
| 8 |
CLOUGH CAPITAL PARTNERS L P |
277,700 |
5,029,000 |
2.46% |
|
|
| 9 |
BlackRock Fund Advisors |
214,542 |
3,885,000 |
1.90% |
|
|
| 10 |
Cormorant Asset Management, LP |
200,000 |
3,622,000 |
1.77% |
|
|
| 11 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
200,000 |
3,622,000 |
1.77% |
|
|
| 12 |
BLACKROCK ADVISORS LLC |
195,103 |
3,533,000 |
1.73% |
|
|
| 13 |
PERCEPTIVE ADVISORS LLC |
152,000 |
2,753,000 |
1.35% |
|
|
| 14 |
Alyeska Investment Group, L.P. |
144,348 |
2,614,000 |
1.28% |
|
|
| 15 |
GOLDMAN SACHS GROUP INC |
119,081 |
2,157,000 |
1.05% |
|
|
| 16 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
116,267 |
2,106,000 |
1.03% |
|
|
| 17 |
BlackRock Group LTD |
113,200 |
2,050,000 |
1.00% |
|
|
| 18 |
BAKER BROS. ADVISORS LP |
100,000 |
1,811,000 |
0.89% |
|
|
| 19 |
Rock Springs Capital Management LP |
87,274 |
1,581,000 |
0.77% |
|
|
| 20 |
NORTHERN TRUST CORP |
86,020 |
1,557,000 |
0.76% |
|
|
| 21 |
D. E. Shaw & Co., Inc. |
85,163 |
1,542,000 |
0.75% |
|
|
| 22 |
Allianz Asset Management GmbH |
80,000 |
1,448,000 |
0.71% |
|
|
| 23 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
70,900 |
1,284,000 |
0.63% |
|
|
| 24 |
STATE STREET CORP |
62,385 |
1,129,000 |
0.55% |
|
|
| 25 |
BlackRock Institutional Trust Company, N.A. |
62,089 |
1,124,000 |
0.55% |
|
|
| 26 |
GEODE CAPITAL MANAGEMENT, LLC |
56,216 |
1,018,000 |
0.50% |
|
|
| 27 |
Iguana Healthcare Management, LLC |
50,000 |
906,000 |
0.44% |
|
|
| 28 |
BlackRock Finance, Inc. |
42,700 |
773,000 |
0.38% |
|
|
| 29 |
Lombard Odier Asset Management (USA) Corp |
41,533 |
752,000 |
0.37% |
|
|
| 30 |
FRED ALGER MANAGEMENT, LLC |
40,000 |
724,000 |
0.35% |
|
|
| 31 |
Weiss Multi-Strategy Advisers LLC |
35,000 |
634,000 |
0.31% |
|
|
| 32 |
BlackRock Investment Management, LLC |
34,008 |
616,000 |
0.30% |
|
|
| 33 |
MILLENNIUM MANAGEMENT LLC |
33,024 |
598,000 |
0.29% |
|
|
| 34 |
DEUTSCHE BANK AG\ |
30,413 |
550,000 |
0.27% |
|
|
| 35 |
MORGAN STANLEY |
30,038 |
544,000 |
0.27% |
|
|
| 36 |
Bank of New York Mellon Corp |
29,199 |
528,000 |
0.26% |
|
|
| 37 |
Spark Investment Management LLC |
21,200 |
383,000 |
0.19% |
|
|
| 38 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
14,500 |
263,000 |
0.13% |
|
|
| 39 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
13,110 |
237,000 |
0.12% |
|
|
| 40 |
Cubist Systematic Strategies, LLC |
13,077 |
237,000 |
0.12% |
|
|
| 41 |
Nationwide Fund Advisors |
5,612 |
102,000 |
0.05% |
|
|
| 42 |
AMERICAN INTERNATIONAL GROUP, INC. |
4,912 |
88,956 |
0.04% |
|
|
| 43 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
3,632 |
66,000 |
0.03% |
|
|
| 44 |
TEACHERS ADVISORS, LLC |
405,746 |
53,000 |
0.03% |
|
|
| 45 |
STRS OHIO |
2,700 |
49,000 |
0.02% |
|
|
| 46 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
2,120 |
38,000 |
0.02% |
|
|
| 47 |
CITIGROUP INC |
1,339 |
24,000 |
0.01% |
|
|
| 48 |
Tower Research Capital LLC (TRC) |
1,288 |
23,000 |
0.01% |
|
|
| 49 |
UBS Group AG |
768 |
14,000 |
0.01% |
|
|
| 50 |
BARCLAYS PLC |
445 |
8,000 |
0.00% |
|
|
