| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,245,836 | 99,098,000 | 20.95% | ||
| 2 | NEA Management Company, LLC | 3,506,649 | 81,845,000 | 17.30% | ||
| 3 | EAGLE ASSET MANAGEMENT INC | 1,245,900 | 29,079,000 | 6.15% | ||
| 4 | Aisling Capital LLC | 1,102,046 | 25,722,000 | 5.44% | ||
| 5 | JENNISON ASSOCIATES LLC | 1,013,343 | 23,651,000 | 5.00% | ||
| 6 | TimesSquare Capital Management, LLC | 826,576 | 19,292,000 | 4.08% | ||
| 7 | Invesco Ltd. | 773,484 | 18,054,000 | 3.82% | ||
| 8 | FRANKLIN RESOURCES INC | 607,600 | 14,181,000 | 3.00% | ||
| 9 | VANGUARD GROUP INC | 488,924 | 11,412,000 | 2.41% | ||
| 10 | PERCEPTIVE ADVISORS LLC | 472,000 | 11,016,000 | 2.33% | ||
| 11 | BlackRock Fund Advisors | 393,260 | 9,179,000 | 1.94% | ||
| 12 | Avoro Capital Advisors LLC | 363,250 | 8,478,000 | 1.79% | ||
| 13 | BLACKROCK ADVISORS LLC | 328,839 | 7,675,000 | 1.62% | ||
| 14 | Rock Springs Capital Management LP | 300,001 | 7,002,000 | 1.48% | ||
| 15 | SENZAR ASSET MANAGEMENT, LLC | 295,300 | 6,892,302 | 1.46% | ||
| 16 | New Leaf Venture Partners, L.L.C. | 281,592 | 6,572,000 | 1.39% | ||
| 17 | BAKER BROS. ADVISORS LP | 275,000 | 6,419,000 | 1.36% | ||
| 18 | CITADEL ADVISORS LLC | 235,682 | 5,501,000 | 1.16% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 226,256 | 5,281,000 | 1.12% | ||
| 20 | STATE STREET CORP | 212,896 | 4,968,000 | 1.05% | ||
| 21 | BlackRock Group LTD | 199,800 | 4,664,000 | 0.99% | ||
| 22 | SABBY MANAGEMENT, LLC | 190,000 | 4,435,000 | 0.94% | ||
| 23 | BALYASNY ASSET MANAGEMENT L.P. | 181,500 | 4,236,000 | 0.90% | ||
| 24 | D. E. Shaw & Co., Inc. | 172,411 | 4,024,000 | 0.85% | ||
| 25 | Cormorant Asset Management, LP | 170,000 | 3,968,000 | 0.84% | ||
| 26 | PALISADE CAPITAL MANAGEMENT, LP | 167,278 | 3,904,000 | 0.83% | ||
| 27 | NORTHERN TRUST CORP | 157,770 | 3,682,000 | 0.78% | ||
| 28 | CLOUGH CAPITAL PARTNERS L P | 147,584 | 3,445,000 | 0.73% | ||
| 29 | Allianz Asset Management GmbH | 121,720 | 2,841,000 | 0.60% | ||
| 30 | TEACHERS ADVISORS, LLC | 118,055 | 2,755,000 | 0.58% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 107,913 | 2,518,000 | 0.53% | ||
| 32 | Tourbillon Capital Partners, L.P. | 103,213 | 2,409,000 | 0.51% | ||
| 33 | CITIGROUP INC | 81,419 | 1,900,000 | 0.40% | ||
| 34 | AMERIPRISE FINANCIAL INC | 79,135 | 1,847,000 | 0.39% | ||
| 35 | Alyeska Investment Group, L.P. | 78,098 | 1,823,000 | 0.39% | ||
| 36 | BlackRock Investment Management, LLC | 77,515 | 1,809,000 | 0.38% | ||
| 37 | Iguana Healthcare Management, LLC | 75,000 | 1,751,000 | 0.37% | ||
| 38 | Abingworth LLP | 70,000 | 1,624,000 | 0.34% | ||
| 39 | TFS CAPITAL LLC | 68,081 | 1,589,000 | 0.34% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 67,168 | 1,568,000 | 0.33% | ||
| 41 | BlackRock Finance, Inc. | 57,561 | 1,343,000 | 0.28% | ||
| 42 | FRED ALGER MANAGEMENT, LLC | 55,400 | 1,293,000 | 0.27% | ||
| 43 | Bank of New York Mellon Corp | 52,507 | 1,225,000 | 0.26% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 47,536 | 1,110,000 | 0.23% | ||
| 45 | Informed Momentum Co LLC | 45,172 | 1,054,000 | 0.22% | ||
| 46 | RUSSELL FRANK CO/ | 35,992 | 840,000 | 0.18% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,263 | 660,000 | 0.14% | ||
| 48 | MONASHEE INVESTMENT MANAGEMENT LLC | 25,965 | 606,000 | 0.13% | ||
| 49 | A.R.T. Advisors, LLC | 24,810 | 579,000 | 0.12% | ||
| 50 | MORGAN STANLEY | 23,468 | 548,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
