| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,277,136 | 144,653,000 | 14.05% | ||
| 2 | NEA Management Company, LLC | 3,506,649 | 119,226,000 | 11.58% | ||
| 3 | JENNISON ASSOCIATES LLC | 2,439,756 | 82,513,000 | 8.02% | ||
| 4 | TimesSquare Capital Management, LLC | 2,279,311 | 77,086,000 | 7.49% | ||
| 5 | EAGLE ASSET MANAGEMENT INC | 1,329,181 | 44,952,000 | 4.37% | ||
| 6 | BlackRock Fund Advisors | 1,325,981 | 44,845,000 | 4.36% | ||
| 7 | VANGUARD GROUP INC | 1,013,911 | 34,290,000 | 3.33% | ||
| 8 | Avoro Capital Advisors LLC | 805,926 | 27,256,000 | 2.65% | ||
| 9 | BALYASNY ASSET MANAGEMENT L.P. | 749,001 | 25,331,000 | 2.46% | ||
| 10 | GREAT POINT PARTNERS LLC | 679,403 | 22,977,000 | 2.23% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 601,618 | 20,347,000 | 1.98% | ||
| 12 | STATE STREET CORP | 550,915 | 18,633,000 | 1.81% | ||
| 13 | Invesco Ltd. | 539,259 | 18,238,000 | 1.77% | ||
| 14 | EcoR1 Capital, LLC | 522,000 | 17,654,000 | 1.72% | ||
| 15 | FRANKLIN RESOURCES INC | 505,200 | 17,086,000 | 1.66% | ||
| 16 | BLACKROCK ADVISORS LLC | 459,211 | 15,531,000 | 1.51% | ||
| 17 | ORBIMED ADVISORS LLC | 425,600 | 14,394,000 | 1.40% | ||
| 18 | LOOMIS SAYLES & CO L P | 356,318 | 12,051,000 | 1.17% | ||
| 19 | Rock Springs Capital Management LP | 355,000 | 12,006,000 | 1.17% | ||
| 20 | PERCEPTIVE ADVISORS LLC | 331,610 | 11,215,000 | 1.09% | ||
| 21 | BAKER BROS. ADVISORS LP | 326,428 | 11,040,000 | 1.07% | ||
| 22 | EverPoint Asset Management, LLC | 300,000 | 10,146,000 | 0.99% | ||
| 23 | GOLDMAN SACHS GROUP INC | 291,667 | 9,864,000 | 0.96% | ||
| 24 | NORTHERN TRUST CORP | 290,535 | 9,826,000 | 0.95% | ||
| 25 | BLUE JAY CAPITAL MANAGEMENT, LLC | 275,000 | 9,301,000 | 0.90% | ||
| 26 | TEACHERS ADVISORS, LLC | 256,627 | 8,679,000 | 0.84% | ||
| 27 | BlackRock Group LTD | 224,949 | 7,607,000 | 0.74% | ||
| 28 | MARSHALL WACE, LLP | 216,317 | 7,316,000 | 0.71% | ||
| 29 | New Leaf Venture Partners, L.L.C. | 193,944 | 6,559,000 | 0.64% | ||
| 30 | AXA S.A. | 191,769 | 6,486,000 | 0.63% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 184,721 | 6,247,000 | 0.61% | ||
| 32 | Lombard Odier Asset Management (USA) Corp | 175,000 | 5,919,000 | 0.58% | ||
| 33 | Cormorant Asset Management, LP | 172,083 | 5,820,000 | 0.57% | ||
| 34 | Bank of New York Mellon Corp | 170,451 | 5,764,000 | 0.56% | ||
| 35 | Nicholas Investment Partners, LP | 154,156 | 5,214,000 | 0.51% | ||
| 36 | Iguana Healthcare Management, LLC | 150,000 | 5,073,000 | 0.49% | ||
| 37 | CLOUGH CAPITAL PARTNERS L P | 149,684 | 5,062,000 | 0.49% | ||
| 38 | JANA PARTNERS LLC | 149,457 | 5,055,000 | 0.49% | ||
| 39 | Informed Momentum Co LLC | 133,632 | 4,519,000 | 0.44% | ||
| 40 | SEI INVESTMENTS CO | 131,172 | 4,436,000 | 0.43% | ||
| 41 | BANK OF AMERICA CORP /DE/ | 128,072 | 4,331,000 | 0.42% | ||
| 42 | BlackRock Investment Management, LLC | 115,035 | 3,890,000 | 0.38% | ||
| 43 | GOLDMAN SACHS GROUP INC | 115,000 | 3,889,000 | 0.38% | Call | |
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 113,178 | 3,828,000 | 0.37% | ||
| 45 | D. E. Shaw & Co., Inc. | 113,037 | 3,823,000 | 0.37% | ||
| 46 | Allianz Asset Management GmbH | 112,577 | 3,747,000 | 0.36% | ||
| 47 | AMERIPRISE FINANCIAL INC | 110,031 | 3,721,000 | 0.36% | ||
| 48 | ACUTA CAPITAL PARTNERS, LLC | 107,000 | 3,619,000 | 0.35% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 102,400 | 3,464,000 | 0.34% | ||
| 50 | PALISADE CAPITAL MANAGEMENT, LP | 99,215 | 3,355,000 | 0.33% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
