| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,063,136 | 118,847,000 | 13.78% | ||
| 2 | NEA Management Company, LLC | 3,506,649 | 102,569,000 | 11.90% | ||
| 3 | JENNISON ASSOCIATES LLC | 2,514,166 | 73,539,000 | 8.53% | ||
| 4 | TimesSquare Capital Management, LLC | 2,491,526 | 72,877,000 | 8.45% | ||
| 5 | EAGLE ASSET MANAGEMENT INC | 1,344,721 | 39,333,000 | 4.56% | ||
| 6 | BlackRock Fund Advisors | 1,196,544 | 34,999,000 | 4.06% | ||
| 7 | VANGUARD GROUP INC | 941,164 | 27,529,000 | 3.19% | ||
| 8 | GREAT POINT PARTNERS LLC | 800,000 | 23,400,000 | 2.71% | ||
| 9 | Avoro Capital Advisors LLC | 721,663 | 21,109,000 | 2.45% | ||
| 10 | BALYASNY ASSET MANAGEMENT L.P. | 612,031 | 17,902,000 | 2.08% | ||
| 11 | EverPoint Asset Management, LLC | 575,000 | 16,819,000 | 1.95% | ||
| 12 | Invesco Ltd. | 539,278 | 15,774,000 | 1.83% | ||
| 13 | FRANKLIN RESOURCES INC | 505,200 | 14,777,000 | 1.71% | ||
| 14 | STATE STREET CORP | 465,835 | 13,627,000 | 1.58% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 464,369 | 13,583,000 | 1.58% | ||
| 16 | PERCEPTIVE ADVISORS LLC | 462,000 | 13,514,000 | 1.57% | ||
| 17 | BLACKROCK ADVISORS LLC | 420,188 | 12,291,000 | 1.43% | ||
| 18 | LOOMIS SAYLES & CO L P | 365,051 | 10,678,000 | 1.24% | ||
| 19 | Rock Springs Capital Management LP | 354,900 | 10,381,000 | 1.20% | ||
| 20 | BAKER BROS. ADVISORS LP | 326,428 | 9,548,000 | 1.11% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 313,886 | 9,181,000 | 1.06% | ||
| 22 | EcoR1 Capital, LLC | 272,000 | 7,956,000 | 0.92% | ||
| 23 | Lombard Odier Asset Management (USA) Corp | 268,878 | 7,865,000 | 0.91% | ||
| 24 | NORTHERN TRUST CORP | 252,449 | 7,384,000 | 0.86% | ||
| 25 | BlackRock Group LTD | 218,774 | 6,399,000 | 0.74% | ||
| 26 | Numeric Investors LLC | 209,959 | 6,141,000 | 0.71% | ||
| 27 | New Leaf Venture Partners, L.L.C. | 196,544 | 5,749,000 | 0.67% | ||
| 28 | DAFNA Capital Management LLC | 193,642 | 5,664,000 | 0.66% | ||
| 29 | AXA S.A. | 188,634 | 5,518,000 | 0.64% | ||
| 30 | D. E. Shaw & Co., Inc. | 176,563 | 5,164,000 | 0.60% | ||
| 31 | TEACHERS ADVISORS, LLC | 176,429 | 5,161,000 | 0.60% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 175,081 | 5,121,000 | 0.59% | ||
| 33 | Cormorant Asset Management, LP | 172,083 | 5,033,000 | 0.58% | ||
| 34 | ACUTA CAPITAL PARTNERS, LLC | 170,000 | 4,973,000 | 0.58% | ||
| 35 | CLOUGH CAPITAL PARTNERS L P | 158,984 | 4,650,000 | 0.54% | ||
| 36 | Iguana Healthcare Management, LLC | 150,000 | 4,388,000 | 0.51% | ||
| 37 | Bank of New York Mellon Corp | 133,639 | 3,910,000 | 0.45% | ||
| 38 | SEI INVESTMENTS CO | 129,847 | 3,798,000 | 0.44% | ||
| 39 | BANK OF AMERICA CORP /DE/ | 128,338 | 3,754,000 | 0.44% | ||
| 40 | Point72 Asset Management, L.P. | 127,700 | 3,735,000 | 0.43% | ||
| 41 | MONASHEE INVESTMENT MANAGEMENT LLC | 125,965 | 3,684,000 | 0.43% | PRN | |
| 42 | Century Capital Management, LLC | 122,889 | 3,595,000 | 0.42% | ||
| 43 | Allianz Asset Management GmbH | 118,365 | 3,462,000 | 0.40% | ||
| 44 | PALISADE CAPITAL MANAGEMENT, LP | 113,671 | 3,325,000 | 0.39% | ||
| 45 | AMERIPRISE FINANCIAL INC | 113,500 | 3,319,000 | 0.38% | ||
| 46 | Informed Momentum Co LLC | 111,359 | 3,257,000 | 0.38% | ||
| 47 | Nicholas Investment Partners, LP | 111,101 | 3,250,000 | 0.38% | ||
| 48 | Aisling Capital LLC | 102,593 | 3,001,000 | 0.35% | ||
| 49 | TIAA CREF INVESTMENT MANAGEMENT LLC | 102,130 | 2,987,000 | 0.35% | ||
| 50 | BlackRock Investment Management, LLC | 101,247 | 2,961,000 | 0.34% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
