| 1 |
NEA Management Company, LLC |
3,506,649 |
53,827,000 |
26.45% |
|
|
| 2 |
FMR LLC |
3,248,336 |
49,862,000 |
24.50% |
|
|
| 3 |
Aisling Capital LLC |
1,102,046 |
16,916,000 |
8.31% |
|
|
| 4 |
EAGLE ASSET MANAGEMENT INC |
676,189 |
10,379,000 |
5.10% |
|
|
| 5 |
JENNISON ASSOCIATES LLC |
507,703 |
7,793,000 |
3.83% |
|
|
| 6 |
SABBY MANAGEMENT, LLC |
385,185 |
6,773,000 |
3.33% |
|
|
| 7 |
FRANKLIN RESOURCES INC |
407,600 |
6,257,000 |
3.07% |
|
|
| 8 |
CLOUGH CAPITAL PARTNERS L P |
398,600 |
6,119,000 |
3.01% |
|
|
| 9 |
VANGUARD GROUP INC |
343,654 |
5,275,000 |
2.59% |
|
|
| 10 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
231,467 |
3,553,000 |
1.75% |
|
|
| 11 |
BlackRock Fund Advisors |
220,111 |
3,379,000 |
1.66% |
|
|
| 12 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
200,000 |
3,070,000 |
1.51% |
|
|
| 13 |
Cormorant Asset Management, LP |
170,000 |
2,610,000 |
1.28% |
|
|
| 14 |
BLACKROCK ADVISORS LLC |
160,733 |
2,467,000 |
1.21% |
|
|
| 15 |
PERCEPTIVE ADVISORS LLC |
152,000 |
2,333,000 |
1.15% |
|
|
| 16 |
Alyeska Investment Group, L.P. |
124,492 |
1,911,000 |
0.94% |
|
|
| 17 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
102,200 |
1,569,000 |
0.77% |
|
|
| 18 |
BlackRock Group LTD |
100,100 |
1,536,000 |
0.75% |
|
|
| 19 |
BAKER BROS. ADVISORS LP |
100,000 |
1,535,000 |
0.75% |
|
|
| 20 |
NORTHERN TRUST CORP |
87,196 |
1,338,000 |
0.66% |
|
|
| 21 |
STATE STREET CORP |
81,293 |
1,249,000 |
0.61% |
|
|
| 22 |
Allianz Asset Management GmbH |
80,000 |
1,228,000 |
0.60% |
|
|
| 23 |
Iguana Healthcare Management, LLC |
80,000 |
1,228,000 |
0.60% |
|
|
| 24 |
BlackRock Institutional Trust Company, N.A. |
77,794 |
1,194,000 |
0.59% |
|
|
| 25 |
GEODE CAPITAL MANAGEMENT, LLC |
73,870 |
1,133,000 |
0.56% |
|
|
| 26 |
D. E. Shaw & Co., Inc. |
73,292 |
1,125,000 |
0.55% |
|
|
| 27 |
Lombard Odier Asset Management (USA) Corp |
69,069 |
1,060,000 |
0.52% |
|
|
| 28 |
GOLDMAN SACHS GROUP INC |
66,617 |
1,023,000 |
0.50% |
|
|
| 29 |
TURNER INVESTMENTS LLC |
51,440 |
790,000 |
0.39% |
|
|
| 30 |
Rock Springs Capital Management LP |
42,274 |
649,000 |
0.32% |
|
|
| 31 |
DEUTSCHE BANK AG\ |
41,729 |
640,000 |
0.31% |
|
|
| 32 |
FRED ALGER MANAGEMENT, LLC |
40,000 |
614,000 |
0.30% |
|
|
| 33 |
BlackRock Finance, Inc. |
33,289 |
511,000 |
0.25% |
|
|
| 34 |
BlackRock Investment Management, LLC |
33,212 |
510,000 |
0.25% |
|
|
| 35 |
Bank of New York Mellon Corp |
31,854 |
489,000 |
0.24% |
|
|
| 36 |
MONASHEE INVESTMENT MANAGEMENT LLC |
25,965 |
399,000 |
0.20% |
|
|
| 37 |
MILLENNIUM MANAGEMENT LLC |
19,832 |
304,000 |
0.15% |
|
|
| 38 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
14,200 |
218,000 |
0.11% |
|
|
| 39 |
A.R.T. Advisors, LLC |
10,615 |
162,000 |
0.08% |
|
|
| 40 |
TEACHERS ADVISORS, LLC |
7,446 |
114,000 |
0.06% |
|
|
| 41 |
Nationwide Fund Advisors |
5,612 |
86,000 |
0.04% |
|
|
| 42 |
AMERICAN INTERNATIONAL GROUP, INC. |
4,912 |
75,399 |
0.04% |
|
|
| 43 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
3,632 |
56,000 |
0.03% |
|
|
| 44 |
STRS OHIO |
2,600 |
39,000 |
0.02% |
|
|
| 45 |
UBS Group AG |
1,713 |
26,000 |
0.01% |
|
|
| 46 |
WELLS FARGO & COMPANY/MN |
1,616 |
25,000 |
0.01% |
|
|
| 47 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,413 |
22,000 |
0.01% |
|
|
| 48 |
ALLIANCEBERNSTEIN L.P. |
1,100 |
17,000 |
0.01% |
|
|
| 49 |
CITIGROUP INC |
427 |
7,000 |
0.00% |
|
|
| 50 |
BARCLAYS PLC |
236 |
4,000 |
0.00% |
|
|
