| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,710,737 | 142,877,000 | 16.02% | ||
| 2 | NEA Management Company, LLC | 3,506,649 | 106,357,000 | 11.93% | ||
| 3 | JENNISON ASSOCIATES LLC | 2,458,261 | 74,559,000 | 8.36% | ||
| 4 | TimesSquare Capital Management, LLC | 2,423,711 | 73,511,000 | 8.24% | ||
| 5 | BlackRock Fund Advisors | 1,487,486 | 45,115,000 | 5.06% | ||
| 6 | EAGLE ASSET MANAGEMENT INC | 1,322,945 | 40,124,000 | 4.50% | ||
| 7 | VANGUARD GROUP INC | 1,054,757 | 31,990,000 | 3.59% | ||
| 8 | Avoro Capital Advisors LLC | 765,709 | 23,224,000 | 2.60% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 676,553 | 20,520,000 | 2.30% | ||
| 10 | BALYASNY ASSET MANAGEMENT L.P. | 618,975 | 18,774,000 | 2.11% | ||
| 11 | Invesco Ltd. | 539,301 | 16,357,000 | 1.83% | ||
| 12 | STATE STREET CORP | 513,661 | 15,576,000 | 1.75% | ||
| 13 | BLACKROCK ADVISORS LLC | 495,584 | 15,031,000 | 1.69% | ||
| 14 | LOOMIS SAYLES & CO L P | 432,524 | 13,118,000 | 1.47% | ||
| 15 | ORBIMED ADVISORS LLC | 425,600 | 12,908,000 | 1.45% | ||
| 16 | Rock Springs Capital Management LP | 362,600 | 10,998,000 | 1.23% | ||
| 17 | BLUE JAY CAPITAL MANAGEMENT, LLC | 350,000 | 10,616,000 | 1.19% | ||
| 18 | BAKER BROS. ADVISORS LP | 326,428 | 9,901,000 | 1.11% | ||
| 19 | PERCEPTIVE ADVISORS LLC | 325,583 | 9,875,000 | 1.11% | ||
| 20 | NORTHERN TRUST CORP | 314,986 | 9,553,000 | 1.07% | ||
| 21 | MARSHALL WACE, LLP | 277,304 | 8,411,000 | 0.94% | ||
| 22 | TEACHERS ADVISORS, LLC | 263,938 | 8,005,000 | 0.90% | ||
| 23 | BlackRock Group LTD | 254,150 | 7,708,000 | 0.86% | ||
| 24 | MILLENNIUM MANAGEMENT LLC | 246,064 | 7,463,000 | 0.84% | ||
| 25 | JANA PARTNERS LLC | 241,810 | 7,334,000 | 0.82% | ||
| 26 | CLOUGH CAPITAL PARTNERS L P | 230,585 | 6,994,000 | 0.78% | ||
| 27 | Novo Holdings A/S | 216,562 | 6,568,000 | 0.74% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 197,699 | 5,996,000 | 0.67% | ||
| 29 | AXA S.A. | 191,459 | 5,807,000 | 0.65% | ||
| 30 | GOLDMAN SACHS GROUP INC | 178,766 | 5,422,000 | 0.61% | ||
| 31 | New Leaf Venture Partners, L.L.C. | 177,844 | 5,394,000 | 0.60% | ||
| 32 | Cormorant Asset Management, LP | 172,083 | 5,219,000 | 0.59% | ||
| 33 | Tekla Capital Management LLC | 165,200 | 5,011,000 | 0.56% | ||
| 34 | Iguana Healthcare Management, LLC | 150,000 | 4,550,000 | 0.51% | ||
| 35 | Bank of New York Mellon Corp | 148,580 | 4,506,000 | 0.51% | ||
| 36 | SEI INVESTMENTS CO | 145,784 | 4,422,000 | 0.50% | ||
| 37 | Nicholas Investment Partners, LP | 133,942 | 4,063,000 | 0.46% | ||
| 38 | BANK OF AMERICA CORP /DE/ | 132,128 | 4,007,000 | 0.45% | ||
| 39 | SAMLYN CAPITAL, LLC | 127,000 | 3,852,000 | 0.43% | ||
| 40 | BlackRock Investment Management, LLC | 116,899 | 3,546,000 | 0.40% | ||
| 41 | GREAT POINT PARTNERS LLC | 114,080 | 3,460,000 | 0.39% | ||
| 42 | DEUTSCHE BANK AG\ | 112,897 | 3,420,000 | 0.38% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 107,386 | 3,258,000 | 0.37% | ||
| 44 | D. E. Shaw & Co., Inc. | 104,770 | 3,178,000 | 0.36% | ||
| 45 | Allianz Asset Management GmbH | 104,510 | 3,170,000 | 0.36% | ||
| 46 | DAFNA Capital Management LLC | 98,800 | 2,997,000 | 0.34% | ||
| 47 | TIAA CREF INVESTMENT MANAGEMENT LLC | 95,424 | 2,894,000 | 0.32% | ||
| 48 | ACUTA CAPITAL PARTNERS, LLC | 88,500 | 2,684,000 | 0.30% | ||
| 49 | WELLS FARGO & COMPANY/MN | 82,299 | 2,496,000 | 0.28% | ||
| 50 | MORGAN STANLEY | 72,204 | 2,190,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
