| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,230,836 | 146,429,000 | 19.87% | ||
| 2 | NEA Management Company, LLC | 3,506,649 | 121,365,000 | 16.47% | ||
| 3 | EAGLE ASSET MANAGEMENT INC | 1,331,284 | 46,075,000 | 6.25% | ||
| 4 | JENNISON ASSOCIATES LLC | 1,097,201 | 37,974,000 | 5.15% | ||
| 5 | TimesSquare Capital Management, LLC | 1,070,176 | 37,039,000 | 5.03% | ||
| 6 | BlackRock Fund Advisors | 1,013,239 | 35,068,000 | 4.76% | ||
| 7 | Aisling Capital LLC | 820,823 | 28,409,000 | 3.86% | ||
| 8 | Invesco Ltd. | 775,904 | 26,854,000 | 3.64% | ||
| 9 | FRANKLIN RESOURCES INC | 607,600 | 21,029,000 | 2.85% | ||
| 10 | VANGUARD GROUP INC | 580,903 | 20,106,000 | 2.73% | ||
| 11 | PERCEPTIVE ADVISORS LLC | 502,000 | 17,374,000 | 2.36% | ||
| 12 | Avoro Capital Advisors LLC | 354,950 | 12,285,000 | 1.67% | ||
| 13 | BLACKROCK ADVISORS LLC | 324,430 | 11,228,000 | 1.52% | ||
| 14 | STATE STREET CORP | 307,255 | 10,634,000 | 1.44% | ||
| 15 | Rock Springs Capital Management LP | 290,000 | 10,037,000 | 1.36% | ||
| 16 | BAKER BROS. ADVISORS LP | 275,000 | 9,518,000 | 1.29% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 274,368 | 9,496,000 | 1.29% | ||
| 18 | SENZAR ASSET MANAGEMENT, LLC | 247,500 | 8,565,975 | 1.16% | ||
| 19 | D. E. Shaw & Co., Inc. | 224,769 | 7,780,000 | 1.06% | ||
| 20 | BALYASNY ASSET MANAGEMENT L.P. | 202,471 | 7,008,000 | 0.95% | ||
| 21 | BlackRock Group LTD | 195,342 | 6,760,000 | 0.92% | ||
| 22 | New Leaf Venture Partners, L.L.C. | 177,022 | 6,127,000 | 0.83% | ||
| 23 | Cormorant Asset Management, LP | 170,000 | 5,884,000 | 0.80% | ||
| 24 | NORTHERN TRUST CORP | 168,291 | 5,824,000 | 0.79% | ||
| 25 | PALISADE CAPITAL MANAGEMENT, LP | 165,767 | 5,737,000 | 0.78% | ||
| 26 | CITADEL ADVISORS LLC | 153,623 | 5,317,000 | 0.72% | ||
| 27 | Numeric Investors LLC | 151,707 | 5,251,000 | 0.71% | ||
| 28 | TEACHERS ADVISORS, LLC | 121,253 | 4,197,000 | 0.57% | ||
| 29 | Allianz Asset Management GmbH | 120,627 | 4,190,000 | 0.57% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 114,472 | 3,961,000 | 0.54% | ||
| 31 | BANK OF AMERICA CORP /DE/ | 113,614 | 3,933,000 | 0.53% | ||
| 32 | DRIEHAUS CAPITAL MANAGEMENT LLC | 101,038 | 3,497,000 | 0.47% | ||
| 33 | AMERIPRISE FINANCIAL INC | 92,917 | 3,215,000 | 0.44% | ||
| 34 | CITIGROUP INC | 82,899 | 2,869,000 | 0.39% | ||
| 35 | Bank of New York Mellon Corp | 82,458 | 2,854,000 | 0.39% | ||
| 36 | BlackRock Investment Management, LLC | 78,246 | 2,708,000 | 0.37% | ||
| 37 | MOORE CAPITAL MANAGEMENT, LP | 75,000 | 2,596,000 | 0.35% | ||
| 38 | Iguana Healthcare Management, LLC | 75,000 | 2,596,000 | 0.35% | ||
| 39 | Nicholas Investment Partners, LP | 70,970 | 2,456,000 | 0.33% | ||
| 40 | Abingworth LLP | 70,000 | 2,419,000 | 0.33% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 65,286 | 2,260,000 | 0.31% | ||
| 42 | CLOUGH CAPITAL PARTNERS L P | 56,784 | 1,965,000 | 0.27% | ||
| 43 | FRED ALGER MANAGEMENT, LLC | 52,900 | 1,831,000 | 0.25% | ||
| 44 | BlackRock Finance, Inc. | 48,761 | 1,687,000 | 0.23% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 47,451 | 1,643,000 | 0.22% | ||
| 46 | MORGAN STANLEY | 42,767 | 1,480,000 | 0.20% | ||
| 47 | WELLS FARGO & COMPANY/MN | 41,036 | 1,420,000 | 0.19% | ||
| 48 | Informed Momentum Co LLC | 33,378 | 1,155,000 | 0.16% | ||
| 49 | RENAISSANCE TECHNOLOGIES LLC | 31,400 | 1,087,000 | 0.15% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,787 | 996,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
