| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 3,506,649 | 72,518,000 | 15.70% | ||
| 2 | FMR LLC | 3,141,336 | 64,962,000 | 14.06% | ||
| 3 | JENNISON ASSOCIATES LLC | 1,653,569 | 34,196,000 | 7.40% | ||
| 4 | TimesSquare Capital Management, LLC | 1,389,881 | 28,743,000 | 6.22% | ||
| 5 | EAGLE ASSET MANAGEMENT INC | 1,288,730 | 26,650,000 | 5.77% | ||
| 6 | BlackRock Fund Advisors | 1,056,211 | 21,842,000 | 4.73% | ||
| 7 | Aisling Capital LLC | 970,823 | 20,077,000 | 4.35% | ||
| 8 | VANGUARD GROUP INC | 636,414 | 13,161,000 | 2.85% | ||
| 9 | EverPoint Asset Management, LLC | 600,000 | 12,408,000 | 2.69% | ||
| 10 | FRANKLIN RESOURCES INC | 588,400 | 12,168,000 | 2.63% | ||
| 11 | Invesco Ltd. | 586,258 | 12,124,000 | 2.62% | ||
| 12 | PERCEPTIVE ADVISORS LLC | 512,000 | 10,588,000 | 2.29% | ||
| 13 | STATE STREET CORP | 348,398 | 7,203,000 | 1.56% | ||
| 14 | BLACKROCK ADVISORS LLC | 324,404 | 6,709,000 | 1.45% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 299,780 | 6,199,000 | 1.34% | ||
| 16 | Rock Springs Capital Management LP | 290,000 | 5,997,000 | 1.30% | ||
| 17 | BAKER BROS. ADVISORS LP | 275,000 | 5,687,000 | 1.23% | ||
| 18 | BALYASNY ASSET MANAGEMENT L.P. | 265,081 | 5,482,000 | 1.19% | ||
| 19 | SENZAR ASSET MANAGEMENT, LLC | 263,300 | 5,445,044 | 1.18% | ||
| 20 | Numeric Investors LLC | 223,884 | 4,630,000 | 1.00% | ||
| 21 | BlackRock Group LTD | 197,240 | 4,079,000 | 0.88% | ||
| 22 | D. E. Shaw & Co., Inc. | 186,707 | 3,861,000 | 0.84% | ||
| 23 | New Leaf Venture Partners, L.L.C. | 183,884 | 3,803,000 | 0.82% | ||
| 24 | NORTHERN TRUST CORP | 175,336 | 3,626,000 | 0.78% | ||
| 25 | Avoro Capital Advisors LLC | 175,000 | 3,619,000 | 0.78% | ||
| 26 | DAFNA Capital Management LLC | 171,881 | 3,554,000 | 0.77% | ||
| 27 | Cormorant Asset Management, LP | 170,000 | 3,516,000 | 0.76% | ||
| 28 | PALISADE CAPITAL MANAGEMENT, LP | 162,850 | 3,368,000 | 0.73% | ||
| 29 | TEACHERS ADVISORS, LLC | 123,531 | 2,555,000 | 0.55% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 123,424 | 2,552,000 | 0.55% | ||
| 31 | SABBY MANAGEMENT, LLC | 122,600 | 2,535,000 | 0.55% | ||
| 32 | SPHERA FUNDS MANAGEMENT LTD. | 120,000 | 2,482,000 | 0.54% | ||
| 33 | Allianz Asset Management GmbH | 119,566 | 2,472,000 | 0.54% | ||
| 34 | CITADEL ADVISORS LLC | 113,089 | 2,339,000 | 0.51% | ||
| 35 | BANK OF AMERICA CORP /DE/ | 106,851 | 2,209,000 | 0.48% | ||
| 36 | PRICE T ROWE ASSOCIATES INC /MD/ | 93,970 | 1,943,000 | 0.42% | ||
| 37 | AXA S.A. | 92,412 | 1,911,000 | 0.41% | ||
| 38 | Bank of New York Mellon Corp | 89,716 | 1,855,000 | 0.40% | ||
| 39 | Nicholas Investment Partners, LP | 85,343 | 1,765,000 | 0.38% | ||
| 40 | AMERIPRISE FINANCIAL INC | 84,758 | 1,753,000 | 0.38% | ||
| 41 | CITIGROUP INC | 84,450 | 1,747,000 | 0.38% | ||
| 42 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 80,000 | 1,654,000 | 0.36% | ||
| 43 | BlackRock Investment Management, LLC | 78,407 | 1,621,000 | 0.35% | ||
| 44 | Point72 Asset Management, L.P. | 76,700 | 1,586,000 | 0.34% | ||
| 45 | Iguana Healthcare Management, LLC | 75,000 | 1,551,000 | 0.34% | ||
| 46 | Abingworth LLP | 70,000 | 1,448,000 | 0.31% | ||
| 47 | CLOUGH CAPITAL PARTNERS L P | 66,384 | 1,373,000 | 0.30% | ||
| 48 | Century Capital Management, LLC | 58,648 | 1,213,000 | 0.26% | ||
| 49 | Trexquant Investment LP | 52,268 | 1,081,000 | 0.23% | ||
| 50 | TIAA CREF INVESTMENT MANAGEMENT LLC | 50,026 | 1,035,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
