| 1 |
FMR LLC |
3,674,136 |
64,482,000 |
25.08% |
|
|
| 2 |
NEA Management Company, LLC |
3,506,649 |
61,542,000 |
23.93% |
|
|
| 3 |
Aisling Capital LLC |
1,102,046 |
19,341,000 |
7.52% |
|
|
| 4 |
EAGLE ASSET MANAGEMENT INC |
728,697 |
12,788,000 |
4.97% |
|
|
| 5 |
JENNISON ASSOCIATES LLC |
510,106 |
8,952,000 |
3.48% |
|
|
| 6 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
496,387 |
8,712,000 |
3.39% |
|
|
| 7 |
FRANKLIN RESOURCES INC |
407,600 |
7,153,000 |
2.78% |
|
|
| 8 |
CLOUGH CAPITAL PARTNERS L P |
382,100 |
6,706,000 |
2.61% |
|
|
| 9 |
VANGUARD GROUP INC |
381,311 |
6,692,000 |
2.60% |
|
|
| 10 |
BlackRock Fund Advisors |
329,169 |
5,777,000 |
2.25% |
|
|
| 11 |
SABBY MANAGEMENT, LLC |
276,994 |
4,861,000 |
1.89% |
|
|
| 12 |
Rock Springs Capital Management LP |
250,001 |
4,388,000 |
1.71% |
|
|
| 13 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
200,000 |
3,510,000 |
1.37% |
|
|
| 14 |
Cormorant Asset Management, LP |
170,000 |
2,984,000 |
1.16% |
|
|
| 15 |
BLACKROCK ADVISORS LLC |
164,059 |
2,879,000 |
1.12% |
|
|
| 16 |
PERCEPTIVE ADVISORS LLC |
152,000 |
2,668,000 |
1.04% |
|
|
| 17 |
New Leaf Venture Partners, L.L.C. |
131,590 |
2,309,000 |
0.90% |
|
|
| 18 |
Alyeska Investment Group, L.P. |
126,541 |
2,221,000 |
0.86% |
|
|
| 19 |
BAKER BROS. ADVISORS LP |
100,000 |
1,755,000 |
0.68% |
|
|
| 20 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
100,000 |
1,755,000 |
0.68% |
|
|
| 21 |
BlackRock Institutional Trust Company, N.A. |
98,058 |
1,721,000 |
0.67% |
|
|
| 22 |
Tekla Capital Management LLC |
97,197 |
1,706,000 |
0.66% |
|
|
| 23 |
BlackRock Group LTD |
92,200 |
1,618,000 |
0.63% |
|
|
| 24 |
STATE STREET CORP |
91,382 |
1,604,000 |
0.62% |
|
|
| 25 |
NORTHERN TRUST CORP |
87,274 |
1,532,000 |
0.60% |
|
|
| 26 |
GEODE CAPITAL MANAGEMENT, LLC |
85,709 |
1,504,000 |
0.58% |
|
|
| 27 |
Iguana Healthcare Management, LLC |
80,000 |
1,404,000 |
0.55% |
|
|
| 28 |
D. E. Shaw & Co., Inc. |
79,887 |
1,402,000 |
0.55% |
|
|
| 29 |
Lombard Odier Asset Management (USA) Corp |
77,915 |
1,368,000 |
0.53% |
|
|
| 30 |
BlackRock Investment Management, LLC |
59,105 |
1,037,000 |
0.40% |
|
|
| 31 |
DAFNA Capital Management LLC |
56,736 |
996,000 |
0.39% |
|
|
| 32 |
Allianz Asset Management GmbH |
55,000 |
965,000 |
0.38% |
|
|
| 33 |
DEUTSCHE BANK AG\ |
51,559 |
904,000 |
0.35% |
|
|
| 34 |
Bank of New York Mellon Corp |
51,348 |
901,000 |
0.35% |
|
|
| 35 |
GOLDMAN SACHS GROUP INC |
44,482 |
781,000 |
0.30% |
|
|
| 36 |
FRED ALGER MANAGEMENT, LLC |
40,000 |
702,000 |
0.27% |
|
|
| 37 |
TCW GROUP INC |
38,815 |
681,000 |
0.26% |
|
|
| 38 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
35,552 |
624,000 |
0.24% |
|
|
| 39 |
BlackRock Finance, Inc. |
31,389 |
551,000 |
0.21% |
|
|
| 40 |
MONASHEE INVESTMENT MANAGEMENT LLC |
25,965 |
456,000 |
0.18% |
|
PRN |
| 41 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
23,463 |
412,000 |
0.16% |
|
|
| 42 |
TEACHERS ADVISORS, LLC |
18,855 |
331,000 |
0.13% |
|
|
| 43 |
Opaleye Management Inc. |
18,800 |
330,000 |
0.13% |
|
|
| 44 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
18,200 |
320,000 |
0.12% |
|
|
| 45 |
CREDIT SUISSE AG/ |
13,678 |
240,000 |
0.09% |
|
|
| 46 |
RHUMBLINE ADVISERS |
13,560 |
238,000 |
0.09% |
|
|
| 47 |
TFS CAPITAL LLC |
12,973 |
228,000 |
0.09% |
|
|
| 48 |
NEW YORK STATE COMMON RETIREMENT FUND |
11,800 |
207,000 |
0.08% |
|
|
| 49 |
RENAISSANCE TECHNOLOGIES LLC |
11,487 |
202,000 |
0.08% |
|
|
| 50 |
METROPOLITAN LIFE INSURANCE CO/NY |
9,999 |
175,000 |
0.07% |
|
|
