| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 3,185,308 | 53,481,000 | 22.00% | ||
| 2 | Clarus Ventures, LLC | 2,730,765 | 45,849,000 | 18.86% | ||
| 3 | Abingworth LLP | 2,199,012 | 36,877,000 | 15.17% | ||
| 4 | Visium Asset Management, LP | 1,475,000 | 24,766,000 | 10.19% | ||
| 5 | GOLDMAN SACHS GROUP INC | 783,002 | 13,147,000 | 5.41% | ||
| 6 | TEACHERS INSURANCE & ANNUITY ASSOCIATION OF AMERICA | 630,748 | 10,590,000 | 4.36% | ||
| 7 | FMR LLC | 510,600 | 8,573,000 | 3.53% | ||
| 8 | MORGAN STANLEY | 444,154 | 7,458,000 | 3.07% | ||
| 9 | EMERALD ADVISERS, LLC | 212,160 | 3,562,000 | 1.47% | ||
| 10 | WALL STREET ASSOCIATES | 188,400 | 3,163,000 | 1.30% | ||
| 11 | EMERALD MUTUAL FUND ADVISERS TRUST | 187,697 | 3,151,000 | 1.30% | ||
| 12 | SCHRODER INVESTMENT MANAGEMENT GROUP | 179,700 | 3,017,000 | 1.24% | ||
| 13 | FEDERATED HERMES, INC. | 171,300 | 2,876,000 | 1.18% | ||
| 14 | VANGUARD GROUP INC | 171,177 | 2,874,000 | 1.18% | ||
| 15 | LORD, ABBETT & CO. LLC | 168,782 | 2,834,000 | 1.17% | ||
| 16 | BlackRock Fund Advisors | 157,186 | 2,639,000 | 1.09% | ||
| 17 | PURA VIDA INVESTMENTS, LLC | 151,123 | 2,537,000 | 1.04% | ||
| 18 | PUTNAM INVESTMENTS LLC | 99,631 | 1,673,000 | 0.69% | ||
| 19 | PANAGORA ASSET MANAGEMENT INC | 77,991 | 1,309,000 | 0.54% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 77,612 | 1,303,000 | 0.54% | ||
| 21 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 76,000 | 1,276,000 | 0.52% | ||
| 22 | BAMCO INC /NY/ | 68,500 | 1,150,000 | 0.47% | ||
| 23 | Informed Momentum Co LLC | 64,262 | 1,079,000 | 0.44% | ||
| 24 | JPMORGAN CHASE & CO | 50,675 | 851,000 | 0.35% | ||
| 25 | NORTHERN TRUST CORP | 50,600 | 849,000 | 0.35% | ||
| 26 | DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 50,000 | 840,000 | 0.35% | ||
| 27 | BlackRock Institutional Trust Company, N.A. | 42,114 | 707,000 | 0.29% | ||
| 28 | PERCEPTIVE ADVISORS LLC | 37,000 | 621,000 | 0.26% | ||
| 29 | STATE STREET CORP | 26,715 | 449,000 | 0.18% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 25,904 | 435,000 | 0.18% | ||
| 31 | Omega Advisors Inc. | 25,095 | 421,000 | 0.17% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 23,996 | 402,000 | 0.17% | ||
| 33 | Alyeska Investment Group, L.P. | 22,964 | 386,000 | 0.16% | ||
| 34 | BlackRock Investment Management, LLC | 15,256 | 256,000 | 0.11% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14,971 | 251,000 | 0.10% | ||
| 36 | Cubist Systematic Strategies, LLC | 13,799 | 232,000 | 0.10% | ||
| 37 | Spark Investment Management LLC | 13,000 | 218,000 | 0.09% | ||
| 38 | WELLS FARGO & COMPANY/MN | 11,600 | 195,000 | 0.08% | ||
| 39 | Bank of New York Mellon Corp | 11,300 | 189,000 | 0.08% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 10,700 | 180,000 | 0.07% | ||
| 41 | DEUTSCHE BANK AG\ | 4,356 | 72,000 | 0.03% | ||
| 42 | Nationwide Fund Advisors | 3,917 | 66,000 | 0.03% | ||
| 43 | AMERICAN INTERNATIONAL GROUP, INC. | 3,615 | 60,696 | 0.02% | ||
| 44 | TEACHERS ADVISORS, LLC | 3,512 | 59,000 | 0.02% | ||
| 45 | STRS OHIO | 2,000 | 34,000 | 0.01% | ||
| 46 | BLACKROCK ADVISORS LLC | 1,918 | 32,000 | 0.01% | ||
| 47 | BANK OF AMERICA CORP /DE/ | 1,000 | 17,000 | 0.01% | ||
| 48 | CITIGROUP INC | 984 | 17,000 | 0.01% | ||
| 49 | UBS Group AG | 762 | 12,000 | 0.00% | ||
| 50 | BARCLAYS PLC | 327 | 5,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
