| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Clarus Ventures, LLC | 2,730,765 | 16,166,000 | 19.36% | ||
| 2 | Abingworth LLP | 2,199,012 | 13,018,000 | 15.59% | ||
| 3 | Visium Asset Management, LP | 1,645,151 | 9,739,000 | 11.66% | ||
| 4 | ORBIMED ADVISORS LLC | 1,357,500 | 8,036,000 | 9.62% | ||
| 5 | GOLDMAN SACHS GROUP INC | 813,706 | 4,817,000 | 5.77% | ||
| 6 | SENZAR ASSET MANAGEMENT, LLC | 580,851 | 3,438,638 | 4.12% | ||
| 7 | Amici Capital, LLC | 500,000 | 2,960,000 | 3.54% | ||
| 8 | FMR LLC | 500,000 | 2,960,000 | 3.54% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 484,189 | 2,866,000 | 3.43% | ||
| 10 | VANGUARD GROUP INC | 437,710 | 2,591,000 | 3.10% | ||
| 11 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 426,000 | 2,522,000 | 3.02% | ||
| 12 | PURA VIDA INVESTMENTS, LLC | 309,300 | 1,831,000 | 2.19% | ||
| 13 | JPMORGAN CHASE & CO | 288,308 | 1,707,000 | 2.04% | ||
| 14 | BlackRock Fund Advisors | 218,164 | 1,292,000 | 1.55% | ||
| 15 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 217,807 | 1,289,000 | 1.54% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 186,834 | 1,106,000 | 1.32% | ||
| 17 | GLOBEFLEX CAPITAL L P | 181,200 | 1,073,000 | 1.28% | ||
| 18 | A.R.T. Advisors, LLC | 148,820 | 881,000 | 1.06% | ||
| 19 | NORTHERN TRUST CORP | 78,299 | 463,000 | 0.55% | ||
| 20 | Bank of New York Mellon Corp | 70,389 | 416,000 | 0.50% | ||
| 21 | STATE STREET CORP | 66,763 | 394,000 | 0.47% | ||
| 22 | GILDER GAGNON HOWE & CO LLC | 65,097 | 385,000 | 0.46% | ||
| 23 | Birchview Capital, LP | 63,300 | 375,000 | 0.45% | ||
| 24 | Connor, Clark & Lunn Investment Management Ltd. | 54,150 | 321,000 | 0.38% | ||
| 25 | BALYASNY ASSET MANAGEMENT L.P. | 47,430 | 281,000 | 0.34% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 42,939 | 254,000 | 0.30% | ||
| 27 | LEVIN CAPITAL STRATEGIES, L.P. | 37,777 | 224,000 | 0.27% | ||
| 28 | AMERICAN INTERNATIONAL GROUP, INC. | 36,090 | 213,000 | 0.26% | ||
| 29 | TWO SIGMA ADVISERS, LP | 35,695 | 211,000 | 0.25% | ||
| 30 | BLAIR WILLIAM & CO/IL | 31,707 | 187,000 | 0.22% | ||
| 31 | BlackRock Investment Management, LLC | 27,500 | 163,000 | 0.20% | ||
| 32 | TWO SIGMA INVESTMENTS, LP | 24,300 | 144,000 | 0.17% | ||
| 33 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 23,872 | 141,000 | 0.17% | ||
| 34 | BLACKROCK ADVISORS LLC | 22,703 | 134,000 | 0.16% | ||
| 35 | BANK OF AMERICA CORP /DE/ | 21,347 | 126,000 | 0.15% | ||
| 36 | Wellington Shields Capital Management, LLC | 18,300 | 108,000 | 0.13% | ||
| 37 | MENTA CAPITAL LLC | 15,231 | 90,000 | 0.11% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,955 | 89,000 | 0.11% | ||
| 39 | TFS CAPITAL LLC | 12,705 | 75,000 | 0.09% | ||
| 40 | Parallax Volatility Advisers, L.P. | 11,900 | 70,000 | 0.08% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 11,000 | 66,000 | 0.08% | ||
| 42 | Nationwide Fund Advisors | 9,022 | 53,000 | 0.06% | ||
| 43 | MORGAN STANLEY | 6,218 | 37,000 | 0.04% | ||
| 44 | NEW YORK STATE COMMON RETIREMENT FUND | 6,100 | 36,000 | 0.04% | ||
| 45 | BlackRock Group LTD | 5,463 | 32,000 | 0.04% | ||
| 46 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 4,251 | 25,000 | 0.03% | ||
| 47 | WELLS FARGO & COMPANY/MN | 3,740 | 22,000 | 0.03% | ||
| 48 | UBS Group AG | 3,000 | 18,000 | 0.02% | ||
| 49 | CITIGROUP INC | 2,440 | 14,000 | 0.02% | ||
| 50 | Creative Planning | 2,000 | 12,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
