| 1 |
ORBIMED ADVISORS LLC |
3,185,306 |
80,365,000 |
21.84% |
|
|
| 2 |
Clarus Ventures, LLC |
2,730,765 |
68,897,000 |
18.72% |
|
|
| 3 |
Abingworth LLP |
2,199,012 |
55,151,000 |
14.99% |
|
|
| 4 |
Visium Asset Management, LP |
1,475,000 |
37,214,000 |
10.11% |
|
|
| 5 |
GOLDMAN SACHS GROUP INC |
783,001 |
19,755,000 |
5.37% |
|
|
| 6 |
TEACHERS INSURANCE & ANNUITY ASSOCIATION OF AMERICA |
624,200 |
15,749,000 |
4.28% |
|
|
| 7 |
FMR LLC |
430,000 |
10,849,000 |
2.95% |
|
|
| 8 |
MORGAN STANLEY |
360,559 |
9,096,000 |
2.47% |
|
|
| 9 |
SCHRODER INVESTMENT MANAGEMENT GROUP |
372,890 |
9,069,000 |
2.46% |
|
|
| 10 |
LORD, ABBETT & CO. LLC |
285,257 |
7,197,000 |
1.96% |
|
|
| 11 |
NEXT CENTURY GROWTH INVESTORS LLC |
226,700 |
5,719,000 |
1.55% |
|
|
| 12 |
PURA VIDA INVESTMENTS, LLC |
241,402 |
5,613,000 |
1.53% |
|
|
| 13 |
VANGUARD GROUP INC |
202,735 |
5,115,000 |
1.39% |
|
|
| 14 |
WALL STREET ASSOCIATES |
188,400 |
4,753,000 |
1.29% |
|
|
| 15 |
BlackRock Fund Advisors |
176,395 |
4,450,000 |
1.21% |
|
|
| 16 |
FEDERATED HERMES, INC. |
171,300 |
4,322,000 |
1.17% |
|
|
| 17 |
Consonance Capital Management LP |
132,135 |
3,334,000 |
0.91% |
|
|
| 18 |
PUTNAM INVESTMENTS LLC |
93,187 |
2,351,000 |
0.64% |
|
|
| 19 |
MILLENNIUM MANAGEMENT LLC |
88,657 |
2,237,000 |
0.61% |
|
|
| 20 |
BAMCO INC /NY/ |
80,500 |
2,031,000 |
0.55% |
|
|
| 21 |
STATE STREET CORP |
66,293 |
1,672,000 |
0.45% |
|
|
| 22 |
Informed Momentum Co LLC |
64,548 |
1,629,000 |
0.44% |
|
|
| 23 |
NORTHERN TRUST CORP |
54,356 |
1,372,000 |
0.37% |
|
|
| 24 |
BLAIR WILLIAM & CO/IL |
53,847 |
1,358,000 |
0.37% |
|
|
| 25 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
43,129 |
1,088,000 |
0.30% |
|
|
| 26 |
BlackRock Institutional Trust Company, N.A. |
42,590 |
1,075,000 |
0.29% |
|
|
| 27 |
DRILL CRAIG A |
39,700 |
1,002,000 |
0.27% |
|
|
| 28 |
GEODE CAPITAL MANAGEMENT, LLC |
35,332 |
891,000 |
0.24% |
|
|
| 29 |
BlackRock Investment Management, LLC |
24,337 |
614,000 |
0.17% |
|
|
| 30 |
Bank of New York Mellon Corp |
19,882 |
501,000 |
0.14% |
|
|
| 31 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
19,829 |
500,000 |
0.14% |
|
|
| 32 |
JPMORGAN CHASE & CO |
17,600 |
444,000 |
0.12% |
|
|
| 33 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
15,181 |
383,000 |
0.10% |
|
|
| 34 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
12,255 |
309,000 |
0.08% |
|
|
| 35 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
11,000 |
278,000 |
0.08% |
|
|
| 36 |
BlackRock Group LTD |
10,893 |
275,000 |
0.07% |
|
|
| 37 |
KOPP INVESTMENT ADVISORS LLC |
10,615 |
268,000 |
0.07% |
|
|
| 38 |
TEACHERS ADVISORS, LLC |
10,162 |
256,000 |
0.07% |
|
|
| 39 |
Nationwide Fund Advisors |
9,122 |
230,000 |
0.06% |
|
|
| 40 |
NEW YORK STATE COMMON RETIREMENT FUND |
6,697 |
169,000 |
0.05% |
|
|
| 41 |
WELLS FARGO & COMPANY/MN |
4,040 |
102,000 |
0.03% |
|
|
| 42 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,932 |
99,204 |
0.03% |
|
|
| 43 |
BLACKROCK ADVISORS LLC |
3,611 |
91,000 |
0.02% |
|
|
| 44 |
DEUTSCHE BANK AG\ |
1,613 |
40,000 |
0.01% |
|
|
| 45 |
BANK OF AMERICA CORP /DE/ |
1,223 |
31,000 |
0.01% |
|
|
| 46 |
Allworth Financial LP |
680 |
17,000 |
0.00% |
|
|
| 47 |
BNP PARIBAS FINANCIAL MARKETS |
559 |
14,104 |
0.00% |
|
|
| 48 |
ROYAL BANK OF CANADA |
429 |
11,000 |
0.00% |
|
|
| 49 |
THOMPSON DAVIS & CO., INC. |
250 |
6,000 |
0.00% |
|
|
| 50 |
WFG Advisors, LP |
200 |
5,000 |
0.00% |
|
|
