| 1 |
Clarus Ventures, LLC |
2,730,765 |
18,678,000 |
20.08% |
|
|
| 2 |
Abingworth LLP |
2,199,012 |
15,041,000 |
16.17% |
|
|
| 3 |
Park West Asset Management LLC |
1,799,037 |
12,305,000 |
13.23% |
|
|
| 4 |
ORBIMED ADVISORS LLC |
1,357,500 |
9,285,000 |
9.98% |
|
|
| 5 |
GOLDMAN SACHS GROUP INC |
806,612 |
5,517,000 |
5.93% |
|
|
| 6 |
MILLENNIUM MANAGEMENT LLC |
638,503 |
4,367,000 |
4.70% |
|
|
| 7 |
DRILL CRAIG A |
523,700 |
3,582,000 |
3.85% |
|
|
| 8 |
VANGUARD GROUP INC |
473,361 |
3,238,000 |
3.48% |
|
|
| 9 |
CANNELL CAPITAL LLC |
438,633 |
3,000,000 |
3.23% |
|
|
| 10 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
393,100 |
2,689,000 |
2.89% |
|
|
| 11 |
SENZAR ASSET MANAGEMENT, LLC |
314,066 |
2,148,211 |
2.31% |
|
|
| 12 |
PURA VIDA INVESTMENTS, LLC |
289,475 |
1,980,000 |
2.13% |
|
|
| 13 |
JPMORGAN CHASE & CO |
283,250 |
1,938,000 |
2.08% |
|
|
| 14 |
BlackRock Fund Advisors |
218,202 |
1,493,000 |
1.61% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
153,606 |
1,051,000 |
1.13% |
|
|
| 16 |
GILDER GAGNON HOWE & CO LLC |
148,833 |
1,018,000 |
1.09% |
|
|
| 17 |
NORTHERN TRUST CORP |
89,606 |
613,000 |
0.66% |
|
|
| 18 |
STATE STREET CORP |
82,717 |
563,000 |
0.61% |
|
|
| 19 |
Bank of New York Mellon Corp |
72,769 |
498,000 |
0.54% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
71,919 |
491,000 |
0.53% |
|
|
| 21 |
Birchview Capital, LP |
63,300 |
433,000 |
0.47% |
|
|
| 22 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
37,000 |
253,000 |
0.27% |
|
|
| 23 |
BlackRock Investment Management, LLC |
29,034 |
199,000 |
0.21% |
|
|
| 24 |
Connor, Clark & Lunn Investment Management Ltd. |
27,200 |
186,000 |
0.20% |
|
|
| 25 |
WELLS FARGO & COMPANY/MN |
26,457 |
182,000 |
0.20% |
|
|
| 26 |
TWO SIGMA INVESTMENTS, LP |
25,500 |
174,000 |
0.19% |
|
|
| 27 |
RAYMOND JAMES & ASSOCIATES |
25,000 |
171,000 |
0.18% |
|
|
| 28 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
21,662 |
148,000 |
0.16% |
|
|
| 29 |
CITADEL ADVISORS LLC |
21,313 |
146,000 |
0.16% |
|
|
| 30 |
BAMCO INC /NY/ |
19,800 |
135,000 |
0.15% |
|
|
| 31 |
FIRST QUADRANT LLC/CA |
18,200 |
124,000 |
0.13% |
|
|
| 32 |
Virtu KCG Holdings LLC |
18,002 |
123,000 |
0.13% |
|
|
| 33 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
17,337 |
119,000 |
0.13% |
|
|
| 34 |
Monarch Partners Asset Management LLC |
16,600 |
114,000 |
0.12% |
|
|
| 35 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
14,158 |
97,000 |
0.10% |
|
|
| 36 |
SG Americas Securities, LLC |
13,097 |
90,000 |
0.10% |
|
|
| 37 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
12,600 |
86,000 |
0.09% |
|
|
| 38 |
MISSION WEALTH MANAGEMENT, LLC |
12,407 |
85,000 |
0.09% |
|
|
| 39 |
TWO SIGMA SECURITIES, LLC |
11,590 |
79,000 |
0.08% |
|
|
| 40 |
CITIGROUP INC |
11,610 |
79,000 |
0.08% |
|
|
| 41 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
11,000 |
76,000 |
0.08% |
|
|
| 42 |
Nationwide Fund Advisors |
9,891 |
68,000 |
0.07% |
|
|
| 43 |
MORGAN STANLEY |
9,513 |
65,000 |
0.07% |
|
|
| 44 |
NEW YORK STATE COMMON RETIREMENT FUND |
6,100 |
42,000 |
0.05% |
|
|
| 45 |
AMERICAN INTERNATIONAL GROUP, INC. |
5,981 |
41,000 |
0.04% |
|
|
| 46 |
Tower Research Capital LLC (TRC) |
3,946 |
27,000 |
0.03% |
|
|
| 47 |
Parallax Volatility Advisers, L.P. |
3,900 |
27,000 |
0.03% |
|
|
| 48 |
UBS Group AG |
3,000 |
21,000 |
0.02% |
|
|
| 49 |
Quantbot Technologies LP |
3,215 |
21,000 |
0.02% |
|
|
| 50 |
FIRST NEW YORK SECURITIES LLC /NY |
3,000 |
20,520 |
0.02% |
|
|
