| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 3,185,308 | 61,126,000 | 21.81% | ||
| 2 | Clarus Ventures, LLC | 2,730,765 | 52,403,000 | 18.70% | ||
| 3 | Abingworth LLP | 2,199,012 | 42,045,000 | 15.00% | ||
| 4 | Visium Asset Management, LP | 1,475,000 | 28,305,000 | 10.10% | ||
| 5 | GOLDMAN SACHS GROUP INC | 783,002 | 15,026,000 | 5.36% | ||
| 6 | TEACHERS INSURANCE & ANNUITY ASSOCIATION OF AMERICA | 630,748 | 12,104,000 | 4.32% | ||
| 7 | FMR LLC | 520,000 | 9,979,000 | 3.56% | ||
| 8 | MORGAN STANLEY | 396,197 | 7,603,000 | 2.71% | ||
| 9 | SCHRODER INVESTMENT MANAGEMENT GROUP | 381,900 | 7,054,000 | 2.52% | ||
| 10 | PURA VIDA INVESTMENTS, LLC | 273,100 | 5,241,000 | 1.87% | ||
| 11 | LORD, ABBETT & CO. LLC | 248,426 | 4,767,000 | 1.70% | ||
| 12 | VANGUARD GROUP INC | 197,565 | 3,791,000 | 1.35% | ||
| 13 | NEXT CENTURY GROWTH INVESTORS LLC | 191,741 | 3,679,000 | 1.31% | ||
| 14 | WALL STREET ASSOCIATES | 188,400 | 3,615,000 | 1.29% | ||
| 15 | FEDERATED HERMES, INC. | 171,300 | 3,287,000 | 1.17% | ||
| 16 | BlackRock Fund Advisors | 159,811 | 3,067,000 | 1.09% | ||
| 17 | PUTNAM INVESTMENTS LLC | 98,903 | 1,898,000 | 0.68% | ||
| 18 | PANAGORA ASSET MANAGEMENT INC | 91,221 | 1,751,000 | 0.62% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 83,014 | 1,593,000 | 0.57% | ||
| 20 | BAMCO INC /NY/ | 80,500 | 1,545,000 | 0.55% | ||
| 21 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 68,400 | 1,313,000 | 0.47% | ||
| 22 | Informed Momentum Co LLC | 64,871 | 1,245,000 | 0.44% | ||
| 23 | STATE STREET CORP | 54,035 | 1,038,000 | 0.37% | ||
| 24 | NORTHERN TRUST CORP | 53,724 | 1,031,000 | 0.37% | ||
| 25 | DRILL CRAIG A | 52,500 | 1,007,000 | 0.36% | ||
| 26 | BlackRock Institutional Trust Company, N.A. | 49,703 | 954,000 | 0.34% | ||
| 27 | BLAIR WILLIAM & CO/IL | 40,836 | 783,000 | 0.28% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 31,845 | 611,000 | 0.22% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 25,904 | 497,000 | 0.18% | ||
| 30 | BlackRock Investment Management, LLC | 17,494 | 336,000 | 0.12% | ||
| 31 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 15,278 | 293,000 | 0.10% | ||
| 32 | Bank of New York Mellon Corp | 15,267 | 293,000 | 0.10% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 11,000 | 212,000 | 0.08% | ||
| 34 | BlackRock Group LTD | 10,893 | 209,000 | 0.07% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 10,700 | 205,000 | 0.07% | ||
| 36 | TEACHERS ADVISORS, LLC | 7,093 | 136,000 | 0.05% | ||
| 37 | Nationwide Fund Advisors | 4,265 | 82,000 | 0.03% | ||
| 38 | AMERICAN INTERNATIONAL GROUP, INC. | 3,615 | 69,372 | 0.02% | ||
| 39 | BLACKROCK ADVISORS LLC | 2,707 | 52,000 | 0.02% | ||
| 40 | BANK OF AMERICA CORP /DE/ | 1,020 | 20,000 | 0.01% | ||
| 41 | Allworth Financial LP | 680 | 13,000 | 0.00% | ||
| 42 | CITIGROUP INC | 346 | 7,000 | 0.00% | ||
| 43 | WELLS FARGO & COMPANY/MN | 297 | 6,000 | 0.00% | ||
| 44 | BARCLAYS PLC | 173 | 4,000 | 0.00% | ||
| 45 | UBS Group AG | 200 | 4,000 | 0.00% | ||
| 46 | BNP PARIBAS FINANCIAL MARKETS | 131 | 2,514 | 0.00% | ||
| 47 | DEUTSCHE BANK AG\ | 2 | 0 | 0.00% | ||
| 48 | STRS OHIO | 0 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
