| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Clarus Ventures, LLC | 2,730,765 | 17,968,000 | 21.88% | ||
| 2 | Abingworth LLP | 2,199,012 | 14,470,000 | 17.62% | ||
| 3 | Park West Asset Management LLC | 1,658,637 | 10,914,000 | 13.29% | ||
| 4 | ORBIMED ADVISORS LLC | 1,357,500 | 8,932,000 | 10.88% | ||
| 5 | CANNELL CAPITAL LLC | 855,997 | 5,632,000 | 6.86% | ||
| 6 | GOLDMAN SACHS GROUP INC | 783,407 | 5,155,000 | 6.28% | ||
| 7 | AMERIPRISE FINANCIAL INC | 503,015 | 3,310,000 | 4.03% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 476,499 | 3,135,000 | 3.82% | ||
| 9 | VANGUARD GROUP INC | 462,216 | 3,041,000 | 3.70% | ||
| 10 | PURA VIDA INVESTMENTS, LLC | 350,000 | 2,303,000 | 2.80% | ||
| 11 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 194,500 | 1,280,000 | 1.56% | ||
| 12 | PRELUDE CAPITAL MANAGEMENT, LLC | 135,116 | 889,000 | 1.08% | ||
| 13 | GILDER GAGNON HOWE & CO LLC | 129,354 | 851,000 | 1.04% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 98,867 | 651,000 | 0.79% | ||
| 15 | Birchview Capital, LP | 63,300 | 417,000 | 0.51% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 63,373 | 416,000 | 0.51% | ||
| 17 | Bank of New York Mellon Corp | 55,496 | 365,000 | 0.44% | ||
| 18 | BAMCO INC /NY/ | 50,000 | 329,000 | 0.40% | ||
| 19 | TIAA CREF INVESTMENT MANAGEMENT LLC | 37,000 | 243,000 | 0.30% | ||
| 20 | BlackRock Fund Advisors | 32,761 | 216,000 | 0.26% | ||
| 21 | Paloma Partners Management Co | 30,025 | 198,000 | 0.24% | ||
| 22 | RAYMOND JAMES & ASSOCIATES | 25,000 | 165,000 | 0.20% | ||
| 23 | Amici Capital, LLC | 25,000 | 165,000 | 0.20% | ||
| 24 | CREDIT SUISSE AG/ | 23,377 | 154,000 | 0.19% | ||
| 25 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 20,021 | 132,000 | 0.16% | ||
| 26 | NORTHERN TRUST CORP | 19,595 | 129,000 | 0.16% | ||
| 27 | FIRST NEW YORK SECURITIES LLC /NY | 15,343 | 100,957 | 0.12% | ||
| 28 | BLAIR WILLIAM & CO/IL | 14,372 | 95,000 | 0.12% | ||
| 29 | MISSION WEALTH MANAGEMENT, LLC | 12,407 | 82,000 | 0.10% | ||
| 30 | WELLS FARGO & COMPANY/MN | 10,355 | 68,000 | 0.08% | ||
| 31 | MORGAN STANLEY | 9,947 | 66,000 | 0.08% | ||
| 32 | CITIGROUP INC | 5,990 | 39,000 | 0.05% | ||
| 33 | UBS Group AG | 5,885 | 39,000 | 0.05% | ||
| 34 | ADVISOR GROUP, INC. | 5,137 | 33,000 | 0.04% | ||
| 35 | Joel Isaacson & Co., LLC | 4,800 | 32,000 | 0.04% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 3,475 | 23,000 | 0.03% | ||
| 37 | BlackRock Investment Management, LLC | 2,301 | 15,000 | 0.02% | ||
| 38 | Parallax Volatility Advisers, L.P. | 2,000 | 13,000 | 0.02% | ||
| 39 | NEW YORK STATE COMMON RETIREMENT FUND | 1,800 | 12,000 | 0.01% | ||
| 40 | JPMORGAN CHASE & CO | 1,217 | 8,000 | 0.01% | ||
| 41 | BANK OF MONTREAL /CAN/ | 1,000 | 7,000 | 0.01% | ||
| 42 | Creative Planning | 1,000 | 7,000 | 0.01% | ||
| 43 | ROYAL BANK OF CANADA | 900 | 6,000 | 0.01% | ||
| 44 | Tower Research Capital LLC (TRC) | 917 | 6,000 | 0.01% | ||
| 45 | BARCLAYS PLC | 826 | 5,000 | 0.01% | ||
| 46 | Allworth Financial LP | 680 | 4,000 | 0.00% | ||
| 47 | WFG Advisors, LP | 610 | 4,000 | 0.00% | ||
| 48 | IFP ADVISORS, INC | 595 | 4,000 | 0.00% | ||
| 49 | WOLVERINE TRADING LP /BD | 493 | 3,254 | 0.00% | ||
| 50 | PNC FINANCIAL SERVICES GROUP, INC. | 159 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
