| 1 |
ORBIMED ADVISORS LLC |
2,980,000 |
30,247,000 |
18.40% |
|
|
| 2 |
Clarus Ventures, LLC |
2,730,765 |
27,717,000 |
16.86% |
|
|
| 3 |
Abingworth LLP |
2,199,012 |
22,320,000 |
13.57% |
|
|
| 4 |
Visium Asset Management, LP |
1,775,000 |
18,016,000 |
10.96% |
|
|
| 5 |
TimesSquare Capital Management, LLC |
1,553,730 |
15,770,000 |
9.59% |
|
|
| 6 |
GOLDMAN SACHS GROUP INC |
783,021 |
7,948,000 |
4.83% |
|
|
| 7 |
SCHRODER INVESTMENT MANAGEMENT GROUP |
542,690 |
5,508,000 |
3.35% |
|
|
| 8 |
Amici Capital, LLC |
500,000 |
5,075,000 |
3.09% |
|
|
| 9 |
FMR LLC |
500,000 |
5,075,000 |
3.09% |
|
|
| 10 |
Cortina Asset Management, LLC |
296,477 |
3,009,000 |
1.83% |
|
|
| 11 |
VANGUARD GROUP INC |
288,895 |
2,932,000 |
1.78% |
|
|
| 12 |
SENZAR ASSET MANAGEMENT, LLC |
244,286 |
2,479,503 |
1.51% |
|
|
| 13 |
BlackRock Fund Advisors |
212,090 |
2,153,000 |
1.31% |
|
|
| 14 |
MILLENNIUM MANAGEMENT LLC |
188,940 |
1,918,000 |
1.17% |
|
|
| 15 |
WADDELL & REED FINANCIAL INC |
125,000 |
1,268,000 |
0.77% |
|
|
| 16 |
JPMORGAN CHASE & CO |
96,610 |
981,000 |
0.60% |
|
|
| 17 |
PUTNAM INVESTMENTS LLC |
93,795 |
952,000 |
0.58% |
|
|
| 18 |
DRILL CRAIG A |
81,314 |
825,000 |
0.50% |
|
|
| 19 |
NORTHERN TRUST CORP |
69,064 |
701,000 |
0.43% |
|
|
| 20 |
Birchview Capital, LP |
68,300 |
693,000 |
0.42% |
|
|
| 21 |
STATE STREET CORP |
66,547 |
676,000 |
0.41% |
|
|
| 22 |
BlackRock Institutional Trust Company, N.A. |
66,483 |
675,000 |
0.41% |
|
|
| 23 |
Consonance Capital Management LP |
59,664 |
606,000 |
0.37% |
|
|
| 24 |
BLAIR WILLIAM & CO/IL |
55,582 |
564,000 |
0.34% |
|
|
| 25 |
FIRST NEW YORK SECURITIES LLC /NY |
49,827 |
505,744 |
0.31% |
|
|
| 26 |
OMT Capital Management LLC |
45,230 |
459,000 |
0.28% |
|
|
| 27 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
40,000 |
406,000 |
0.25% |
|
|
| 28 |
TWO SIGMA INVESTMENTS, LP |
36,679 |
372,000 |
0.23% |
|
|
| 29 |
GEODE CAPITAL MANAGEMENT, LLC |
35,830 |
363,000 |
0.22% |
|
|
| 30 |
CREDIT SUISSE AG/ |
33,038 |
335,000 |
0.20% |
|
|
| 31 |
BlackRock Investment Management, LLC |
27,141 |
275,000 |
0.17% |
|
|
| 32 |
MORGAN STANLEY |
25,580 |
259,000 |
0.16% |
|
|
| 33 |
TEACHERS INSURANCE & ANNUITY ASSOCIATION OF AMERICA |
24,244 |
246,000 |
0.15% |
|
|
| 34 |
KOPP INVESTMENT ADVISORS LLC |
23,910 |
243,000 |
0.15% |
|
|
| 35 |
TFS CAPITAL LLC |
23,245 |
236,000 |
0.14% |
|
|
| 36 |
Parallax Volatility Advisers, L.P. |
22,000 |
223,000 |
0.14% |
|
|
| 37 |
Bank of New York Mellon Corp |
19,972 |
203,000 |
0.12% |
|
|
| 38 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
19,829 |
201,000 |
0.12% |
|
|
| 39 |
Cubist Systematic Strategies, LLC |
19,117 |
194,000 |
0.12% |
|
|
| 40 |
Spark Investment Management LLC |
18,100 |
183,000 |
0.11% |
|
|
| 41 |
GILDER GAGNON HOWE & CO LLC |
15,875 |
161,000 |
0.10% |
|
|
| 42 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
15,243 |
155,000 |
0.09% |
|
|
| 43 |
TWO SIGMA ADVISERS, LP |
15,100 |
153,000 |
0.09% |
|
|
| 44 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
14,755 |
150,000 |
0.09% |
|
|
| 45 |
Nine Chapters Capital Management LLC |
11,600 |
118,000 |
0.07% |
|
|
| 46 |
BANK OF AMERICA CORP /DE/ |
11,212 |
114,000 |
0.07% |
|
|
| 47 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
11,000 |
112,000 |
0.07% |
|
|
| 48 |
BlackRock Group LTD |
10,893 |
111,000 |
0.07% |
|
|
| 49 |
TEACHERS ADVISORS, LLC |
10,162 |
103,000 |
0.06% |
|
|
| 50 |
Nationwide Fund Advisors |
9,122 |
93,000 |
0.06% |
|
|
