| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Clarus Ventures, LLC | 2,730,765 | 24,550,000 | 21.46% | ||
| 2 | Abingworth LLP | 2,199,012 | 19,769,000 | 17.28% | ||
| 3 | Park West Asset Management LLC | 1,680,752 | 15,110,000 | 13.21% | ||
| 4 | ORBIMED ADVISORS LLC | 917,500 | 8,248,000 | 7.21% | ||
| 5 | CANNELL CAPITAL LLC | 855,997 | 7,695,000 | 6.73% | ||
| 6 | GOLDMAN SACHS GROUP INC | 794,882 | 7,146,000 | 6.25% | ||
| 7 | PURA VIDA INVESTMENTS, LLC | 552,664 | 4,968,000 | 4.34% | ||
| 8 | GILDER GAGNON HOWE & CO LLC | 545,694 | 4,906,000 | 4.29% | ||
| 9 | AMERIPRISE FINANCIAL INC | 530,834 | 4,772,000 | 4.17% | ||
| 10 | VANGUARD GROUP INC | 464,576 | 4,177,000 | 3.65% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 323,515 | 2,908,000 | 2.54% | ||
| 12 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 155,200 | 1,395,000 | 1.22% | ||
| 13 | PRELUDE CAPITAL MANAGEMENT, LLC | 146,590 | 1,318,000 | 1.15% | ||
| 14 | BAMCO INC /NY/ | 106,700 | 959,000 | 0.84% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 98,867 | 889,000 | 0.78% | ||
| 16 | RENAISSANCE TECHNOLOGIES LLC | 75,800 | 681,000 | 0.60% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 63,419 | 570,000 | 0.50% | ||
| 18 | Birchview Capital, LP | 63,300 | 569,000 | 0.50% | ||
| 19 | Bank of New York Mellon Corp | 52,395 | 471,000 | 0.41% | ||
| 20 | DEUTSCHE BANK AG\ | 41,303 | 371,000 | 0.32% | ||
| 21 | FIRST NEW YORK SECURITIES LLC /NY | 35,236 | 316,772 | 0.28% | ||
| 22 | BlackRock Fund Advisors | 32,650 | 294,000 | 0.26% | ||
| 23 | RAYMOND JAMES & ASSOCIATES | 26,000 | 234,000 | 0.20% | ||
| 24 | NORTHERN TRUST CORP | 23,895 | 215,000 | 0.19% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 20,650 | 186,000 | 0.16% | ||
| 26 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 18,333 | 165,000 | 0.14% | ||
| 27 | MML INVESTORS SERVICES, INC. | 16,735 | 150,000 | 0.13% | ||
| 28 | CITADEL ADVISORS LLC | 16,391 | 147,000 | 0.13% | ||
| 29 | CREDIT SUISSE AG/ | 15,371 | 138,000 | 0.12% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14,200 | 128,000 | 0.11% | Put | |
| 31 | BLAIR WILLIAM & CO/IL | 13,364 | 120,000 | 0.10% | ||
| 32 | D. E. Shaw & Co., Inc. | 13,029 | 117,000 | 0.10% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 12,377 | 111,000 | 0.10% | ||
| 34 | WELLS FARGO & COMPANY/MN | 10,900 | 97,000 | 0.08% | ||
| 35 | Brandywine Global Investment Management, LLC | 9,700 | 88,000 | 0.08% | ||
| 36 | MORGAN STANLEY | 8,563 | 77,000 | 0.07% | ||
| 37 | CITIGROUP INC | 5,990 | 54,000 | 0.05% | ||
| 38 | UBS Group AG | 5,056 | 45,000 | 0.04% | ||
| 39 | BARCLAYS PLC | 5,000 | 45,000 | 0.04% | ||
| 40 | Joel Isaacson & Co., LLC | 4,800 | 43,000 | 0.04% | ||
| 41 | ADVISOR GROUP, INC. | 3,500 | 31,000 | 0.03% | ||
| 42 | BlackRock Investment Management, LLC | 2,301 | 21,000 | 0.02% | ||
| 43 | Parallax Volatility Advisers, L.P. | 2,000 | 18,000 | 0.02% | ||
| 44 | JPMORGAN CHASE & CO | 1,324 | 12,000 | 0.01% | ||
| 45 | Creative Planning | 1,000 | 9,000 | 0.01% | ||
| 46 | BANK OF AMERICA CORP /DE/ | 1,000 | 9,000 | 0.01% | ||
| 47 | BANK OF MONTREAL /CAN/ | 1,000 | 9,000 | 0.01% | ||
| 48 | Allworth Financial LP | 680 | 6,000 | 0.01% | ||
| 49 | WFG Advisors, LP | 610 | 5,000 | 0.00% | ||
| 50 | IFP ADVISORS, INC | 595 | 5,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
