| 1 |
BVF INC/IL |
3,518,830 |
11,084,000 |
35.37% |
|
|
| 2 |
Capital World Investors |
1,429,000 |
4,501,000 |
14.36% |
|
|
| 3 |
PERCEPTIVE ADVISORS LLC |
723,853 |
2,280,000 |
7.28% |
|
|
| 4 |
ORBIMED ADVISORS LLC |
634,812 |
2,000,000 |
6.38% |
|
|
| 5 |
Alyeska Investment Group, L.P. |
441,260 |
1,390,000 |
4.44% |
|
|
| 6 |
DAFNA Capital Management LLC |
377,695 |
1,190,000 |
3.80% |
|
|
| 7 |
Invesco Private Capital, Inc. |
375,784 |
1,184,000 |
3.78% |
|
|
| 8 |
Tekla Capital Management LLC |
350,000 |
1,103,000 |
3.52% |
|
|
| 9 |
SABBY MANAGEMENT, LLC |
310,808 |
979,000 |
3.12% |
|
|
| 10 |
Point72 Asset Management, L.P. |
310,179 |
977,000 |
3.12% |
|
|
| 11 |
SPHERA FUNDS MANAGEMENT LTD. |
228,029 |
718,000 |
2.29% |
|
|
| 12 |
K2 PRINCIPAL FUND, L.P. |
164,510 |
518,000 |
1.65% |
|
|
| 13 |
Artal Group S.A. |
150,000 |
473,000 |
1.51% |
|
|
| 14 |
RENAISSANCE TECHNOLOGIES LLC |
130,300 |
410,000 |
1.31% |
|
|
| 15 |
Novo Holdings A/S |
127,563 |
402,000 |
1.28% |
|
|
| 16 |
SCHONFELD STRATEGIC ADVISORS LLC |
125,000 |
394,000 |
1.26% |
|
|
| 17 |
MORGAN STANLEY |
82,242 |
259,000 |
0.83% |
|
|
| 18 |
J. Goldman & Co LP |
72,400 |
228,000 |
0.73% |
|
|
| 19 |
State of New Jersey Common Pension Fund D |
65,000 |
205,000 |
0.65% |
|
|
| 20 |
ROYAL BANK OF CANADA |
56,173 |
177,000 |
0.56% |
|
|
| 21 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
55,000 |
173,000 |
0.55% |
|
|
| 22 |
SCOTIA CAPITAL INC. |
35,629 |
112,000 |
0.36% |
|
|
| 23 |
Weiss Multi-Strategy Advisers LLC |
31,500 |
99,000 |
0.32% |
|
|
| 24 |
Virtu KCG Holdings LLC |
23,367 |
74,000 |
0.24% |
|
|
| 25 |
NJ State Employees Deferred Compensation Plan |
20,000 |
63,000 |
0.20% |
|
|
| 26 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
19,277 |
61,000 |
0.19% |
|
|
| 27 |
LEITH WHEELER INVESTMENT COUNSEL LTD. |
16,075 |
51,000 |
0.16% |
|
|
| 28 |
A.R.T. Advisors, LLC |
15,829 |
49,000 |
0.16% |
|
|
| 29 |
Dynamic Technology Lab Private Ltd |
13,001 |
41,000 |
0.13% |
|
|
| 30 |
JPMORGAN CHASE & CO |
10,816 |
34,000 |
0.11% |
|
|
| 31 |
DEUTSCHE BANK AG\ |
10,700 |
33,000 |
0.11% |
|
|
| 32 |
INTERWEST VENTURE MANAGEMENT CO |
8,293 |
26,000 |
0.08% |
|
|
| 33 |
BANK OF MONTREAL /CAN/ |
5,530 |
17,000 |
0.05% |
|
|
| 34 |
Tower Research Capital LLC (TRC) |
3,655 |
11,000 |
0.04% |
|
|
| 35 |
UBS Group AG |
2,530 |
8,000 |
0.03% |
|
|
| 36 |
WELLS FARGO & COMPANY/MN |
2,464 |
8,000 |
0.03% |
|
|
| 37 |
CITIGROUP INC |
700 |
2,000 |
0.01% |
|
|
| 38 |
PRELUDE CAPITAL MANAGEMENT, LLC |
738 |
2,000 |
0.01% |
|
|
| 39 |
FEDERATION DES CAISSES DESJARDINS DU QUEBEC |
40 |
126 |
0.00% |
|
|
