| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAUPOST GROUP LLC/MA | 5,367,300 | 111,801,000 | 49.75% | ||
| 2 | BVF INC/IL | 1,052,381 | 21,921,000 | 9.75% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 970,600 | 20,218,000 | 9.00% | ||
| 4 | ORBIMED ADVISORS LLC | 960,600 | 20,009,000 | 8.90% | ||
| 5 | FRANKLIN RESOURCES INC | 300,000 | 6,249,000 | 2.78% | ||
| 6 | GOLDMAN SACHS GROUP INC | 219,405 | 4,570,000 | 2.03% | ||
| 7 | BLACKROCK ADVISORS LLC | 211,870 | 4,413,000 | 1.96% | ||
| 8 | WEXFORD CAPITAL LP | 208,850 | 4,350,000 | 1.94% | ||
| 9 | SPHERA FUNDS MANAGEMENT LTD. | 200,000 | 4,166,000 | 1.85% | ||
| 10 | HELLMAN JORDAN MANAGEMENT CO INC /MA/ | 173,622 | 3,616,000 | 1.61% | ||
| 11 | Cormorant Asset Management, LP | 150,000 | 3,125,000 | 1.39% | ||
| 12 | FMR LLC | 142,900 | 2,977,000 | 1.32% | ||
| 13 | BlackRock Group LTD | 123,195 | 2,567,000 | 1.14% | ||
| 14 | Sio Capital Management, LLC | 108,915 | 2,269,000 | 1.01% | ||
| 15 | EcoR1 Capital, LLC | 100,000 | 2,083,000 | 0.93% | ||
| 16 | Alyeska Investment Group, L.P. | 94,052 | 1,959,000 | 0.87% | ||
| 17 | TUDOR INVESTMENT CORP ET AL | 77,700 | 1,618,000 | 0.72% | ||
| 18 | ACUTA CAPITAL PARTNERS, LLC | 60,730 | 1,265,000 | 0.56% | ||
| 19 | Achievement Holdings L.P. | 55,000 | 1,146,000 | 0.51% | ||
| 20 | Avoro Capital Advisors LLC | 50,000 | 1,042,000 | 0.46% | ||
| 21 | CITADEL ADVISORS LLC | 45,178 | 941,000 | 0.42% | ||
| 22 | Redmile Group, LLC | 25,235 | 526,000 | 0.23% | ||
| 23 | BlackRock Fund Advisors | 22,920 | 477,000 | 0.21% | ||
| 24 | DEUTSCHE BANK AG\ | 17,417 | 362,000 | 0.16% | ||
| 25 | BlackRock Investment Management, LLC | 13,730 | 286,000 | 0.13% | ||
| 26 | BlackRock Institutional Trust Company, N.A. | 13,285 | 277,000 | 0.12% | ||
| 27 | MORGAN STANLEY | 10,723 | 223,000 | 0.10% | ||
| 28 | BlackRock Finance, Inc. | 10,550 | 220,000 | 0.10% | ||
| 29 | UBS Group AG | 858 | 18,000 | 0.01% | ||
| 30 | ROYAL BANK OF CANADA | 600 | 12,000 | 0.01% | ||
| 31 | CT Financial Advisors LLC | 500 | 10,415 | 0.00% | ||
| 32 | ACADIAN ASSET MANAGEMENT LLC | 351 | 7,000 | 0.00% | ||
| 33 | Tower Research Capital LLC (TRC) | 329 | 7,000 | 0.00% | ||
| 34 | First Horizon Advisors, Inc. | 3 | 0 | 0.00% | ||
| 35 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 10 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
