| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAUPOST GROUP LLC/MA | 5,367,300 | 204,226,000 | 52.08% | ||
| 2 | BVF INC/IL | 1,008,981 | 38,392,000 | 9.79% | ||
| 3 | ORBIMED ADVISORS LLC | 960,600 | 36,551,000 | 9.32% | ||
| 4 | Assured Investment Management LLC | 644,924 | 24,539,000 | 6.26% | ||
| 5 | FRANKLIN RESOURCES INC | 300,000 | 11,415,000 | 2.91% | ||
| 6 | CLOUGH CAPITAL PARTNERS L P | 265,200 | 10,091,000 | 2.57% | ||
| 7 | Cormorant Asset Management, LP | 255,000 | 9,703,000 | 2.47% | ||
| 8 | GOLDMAN SACHS GROUP INC | 203,205 | 7,732,000 | 1.97% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 179,275 | 6,821,000 | 1.74% | ||
| 10 | EcoR1 Capital, LLC | 158,985 | 6,049,000 | 1.54% | ||
| 11 | HELLMAN JORDAN MANAGEMENT CO INC /MA/ | 158,660 | 6,037,000 | 1.54% | ||
| 12 | SPHERA FUNDS MANAGEMENT LTD. | 150,000 | 5,708,000 | 1.46% | ||
| 13 | FMR LLC | 142,900 | 5,437,000 | 1.39% | ||
| 14 | MONASHEE INVESTMENT MANAGEMENT LLC | 100,000 | 3,805,000 | 0.97% | PRN | |
| 15 | BlackRock Group LTD | 61,875 | 2,354,000 | 0.60% | ||
| 16 | WEXFORD CAPITAL LP | 58,268 | 2,217,000 | 0.57% | ||
| 17 | Motley Fool Asset Management LLC | 57,000 | 2,169,000 | 0.55% | ||
| 18 | ACADIAN ASSET MANAGEMENT LLC | 47,157 | 1,795,000 | 0.46% | ||
| 19 | ALPS ADVISORS INC | 46,146 | 1,756,000 | 0.45% | ||
| 20 | SABBY MANAGEMENT, LLC | 35,050 | 1,334,000 | 0.34% | ||
| 21 | MORGAN STANLEY | 22,727 | 864,000 | 0.22% | ||
| 22 | A.R.T. Advisors, LLC | 16,241 | 617,000 | 0.16% | ||
| 23 | D. E. Shaw & Co., Inc. | 12,602 | 480,000 | 0.12% | ||
| 24 | BlackRock Institutional Trust Company, N.A. | 12,375 | 471,000 | 0.12% | ||
| 25 | ROYAL BANK OF CANADA | 10,350 | 393,000 | 0.10% | ||
| 26 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 6,500 | 247,000 | 0.06% | ||
| 27 | STATE STREET CORP | 6,378 | 243,000 | 0.06% | ||
| 28 | RENAISSANCE TECHNOLOGIES LLC | 5,944 | 226,000 | 0.06% | ||
| 29 | Virtu KCG Holdings LLC | 5,709 | 217,000 | 0.06% | ||
| 30 | DEUTSCHE BANK AG\ | 2,042 | 77,000 | 0.02% | ||
| 31 | CITADEL ADVISORS LLC | 1,876 | 71,000 | 0.02% | ||
| 32 | UBS Group AG | 1,200 | 46,000 | 0.01% | ||
| 33 | BlackRock Finance, Inc. | 750 | 29,000 | 0.01% | ||
| 34 | INTEGRATED WEALTH MANAGEMENT | 500 | 19,000 | 0.00% | ||
| 35 | Tower Research Capital LLC (TRC) | 259 | 10,000 | 0.00% | ||
| 36 | Invesco Ltd. | 254 | 10,000 | 0.00% | ||
| 37 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 62 | 2,000 | 0.00% | ||
| 38 | First Horizon Advisors, Inc. | 19 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
