| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAUPOST GROUP LLC/MA | 5,367,300 | 101,979,000 | 51.67% | ||
| 2 | BVF INC/IL | 1,441,287 | 27,384,000 | 13.88% | ||
| 3 | Assured Investment Management LLC | 1,102,924 | 20,956,000 | 10.62% | ||
| 4 | ORBIMED ADVISORS LLC | 960,600 | 18,251,000 | 9.25% | ||
| 5 | Cormorant Asset Management, LP | 335,068 | 6,366,000 | 3.23% | ||
| 6 | FMR LLC | 142,900 | 2,715,000 | 1.38% | ||
| 7 | Tekla Capital Management LLC | 136,547 | 2,594,000 | 1.31% | ||
| 8 | CLOUGH CAPITAL PARTNERS L P | 136,064 | 2,585,000 | 1.31% | ||
| 9 | SPHERA FUNDS MANAGEMENT LTD. | 121,500 | 2,309,000 | 1.17% | ||
| 10 | Sio Capital Management, LLC | 100,000 | 1,900,000 | 0.96% | ||
| 11 | EcoR1 Capital, LLC | 100,017 | 1,900,000 | 0.96% | ||
| 12 | MONASHEE INVESTMENT MANAGEMENT LLC | 81,805 | 1,554,000 | 0.79% | ||
| 13 | SABBY MANAGEMENT, LLC | 70,000 | 1,330,000 | 0.67% | ||
| 14 | HELLMAN JORDAN MANAGEMENT CO INC /MA/ | 62,769 | 1,192,000 | 0.60% | ||
| 15 | ALPS ADVISORS INC | 61,275 | 1,164,000 | 0.59% | ||
| 16 | Motley Fool Wealth Management, LLC | 58,291 | 1,108,000 | 0.56% | ||
| 17 | MORGAN STANLEY | 23,911 | 455,000 | 0.23% | ||
| 18 | ACADIAN ASSET MANAGEMENT LLC | 20,488 | 390,000 | 0.20% | ||
| 19 | D. E. Shaw & Co., Inc. | 19,011 | 361,000 | 0.18% | ||
| 20 | RENAISSANCE TECHNOLOGIES LLC | 17,120 | 325,000 | 0.16% | ||
| 21 | A.R.T. Advisors, LLC | 11,928 | 226,000 | 0.11% | ||
| 22 | DEUTSCHE BANK AG\ | 11,833 | 224,000 | 0.11% | ||
| 23 | ROYAL BANK OF CANADA | 1,976 | 38,000 | 0.02% | ||
| 24 | UBS Group AG | 1,176 | 23,000 | 0.01% | ||
| 25 | JPMORGAN CHASE & CO | 1,000 | 19,000 | 0.01% | ||
| 26 | INTEGRATED WEALTH MANAGEMENT | 500 | 10,000 | 0.01% | ||
| 27 | Creative Planning | 50 | 1,000 | 0.00% | ||
| 28 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 42 | 1,000 | 0.00% | ||
| 29 | CITIGROUP INC | 54 | 1,000 | 0.00% | ||
| 30 | BANK OF AMERICA CORP /DE/ | 33 | 1,000 | 0.00% | ||
| 31 | First Horizon Advisors, Inc. | 19 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
