| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAUPOST GROUP LLC/MA | 5,367,300 | 152,002,000 | 52.10% | ||
| 2 | BVF INC/IL | 1,177,481 | 33,346,000 | 11.43% | ||
| 3 | ORBIMED ADVISORS LLC | 960,600 | 27,204,000 | 9.33% | ||
| 4 | FRANKLIN RESOURCES INC | 300,000 | 8,496,000 | 2.91% | ||
| 5 | Cormorant Asset Management, LP | 255,000 | 7,222,000 | 2.48% | ||
| 6 | Assured Investment Management LLC | 239,637 | 6,787,000 | 2.33% | ||
| 7 | GOLDMAN SACHS GROUP INC | 226,878 | 6,425,000 | 2.20% | ||
| 8 | HELLMAN JORDAN MANAGEMENT CO INC /MA/ | 210,604 | 5,964,000 | 2.04% | ||
| 9 | WEXFORD CAPITAL LP | 207,463 | 5,875,000 | 2.01% | ||
| 10 | SPHERA FUNDS MANAGEMENT LTD. | 180,000 | 5,098,000 | 1.75% | ||
| 11 | EcoR1 Capital, LLC | 158,985 | 4,502,000 | 1.54% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 150,638 | 4,266,000 | 1.46% | ||
| 13 | FMR LLC | 142,900 | 4,047,000 | 1.39% | ||
| 14 | Gruss Capital Management LP | 125,000 | 3,540,000 | 1.21% | ||
| 15 | MONASHEE INVESTMENT MANAGEMENT LLC | 100,000 | 2,832,000 | 0.97% | ||
| 16 | Alyeska Investment Group, L.P. | 96,918 | 2,745,000 | 0.94% | ||
| 17 | SABBY MANAGEMENT, LLC | 90,060 | 2,550,000 | 0.87% | ||
| 18 | Sio Capital Management, LLC | 67,455 | 1,910,000 | 0.65% | ||
| 19 | BlackRock Group LTD | 61,875 | 1,752,000 | 0.60% | ||
| 20 | CITADEL ADVISORS LLC | 44,520 | 1,261,000 | 0.43% | ||
| 21 | Point72 Asset Management, L.P. | 42,050 | 1,191,000 | 0.41% | ||
| 22 | MORGAN STANLEY | 22,642 | 641,000 | 0.22% | ||
| 23 | BLUE ARROW CAPITAL MANAGEMENT LLC | 15,000 | 425,000 | 0.15% | ||
| 24 | Rotella Capital Management, Inc. | 14,600 | 413,000 | 0.14% | ||
| 25 | D. E. Shaw & Co., Inc. | 14,381 | 407,000 | 0.14% | ||
| 26 | BlackRock Institutional Trust Company, N.A. | 12,375 | 350,000 | 0.12% | ||
| 27 | ROYAL BANK OF CANADA | 11,550 | 327,000 | 0.11% | ||
| 28 | ACADIAN ASSET MANAGEMENT LLC | 2,304 | 65,000 | 0.02% | ||
| 29 | UBS Group AG | 1,200 | 34,000 | 0.01% | ||
| 30 | BlackRock Finance, Inc. | 750 | 21,000 | 0.01% | ||
| 31 | INTEGRATED WEALTH MANAGEMENT | 500 | 14,000 | 0.00% | ||
| 32 | Tower Research Capital LLC (TRC) | 340 | 10,000 | 0.00% | ||
| 33 | Cambria Investment Management, L.P. | 79 | 2,000 | 0.00% | ||
| 34 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 49 | 1,000 | 0.00% | ||
| 35 | First Horizon Advisors, Inc. | 13 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
