| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,881,581 | 148,704,000 | 18.26% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,255,396 | 86,404,000 | 10.61% | ||
| 3 | ORBIMED ADVISORS LLC | 1,889,000 | 72,368,000 | 8.88% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,626,583 | 62,314,000 | 7.65% | ||
| 5 | RA CAPITAL MANAGEMENT, L.P. | 1,554,918 | 59,569,000 | 7.31% | ||
| 6 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 815,943 | 31,259,000 | 3.84% | ||
| 7 | JENNISON ASSOCIATES LLC | 770,734 | 29,527,000 | 3.62% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 741,085 | 28,391,000 | 3.49% | ||
| 9 | BlackRock Fund Advisors | 664,782 | 25,468,000 | 3.13% | ||
| 10 | Redmile Group, LLC | 559,611 | 21,439,000 | 2.63% | ||
| 11 | PFM Health Sciences, LP | 541,983 | 20,763,000 | 2.55% | ||
| 12 | Palo Alto Investors LP | 532,918 | 20,416,000 | 2.51% | ||
| 13 | WESTFIELD CAPITAL MANAGEMENT CO LP | 512,930 | 19,650,000 | 2.41% | ||
| 14 | Cormorant Asset Management, LP | 350,000 | 13,409,000 | 1.65% | ||
| 15 | PERCEPTIVE ADVISORS LLC | 350,000 | 13,409,000 | 1.65% | ||
| 16 | GUGGENHEIM CAPITAL LLC | 265,175 | 10,159,000 | 1.25% | ||
| 17 | NORGES BANK | 254,331 | 9,743,000 | 1.20% | ||
| 18 | VANGUARD GROUP INC | 242,657 | 9,296,000 | 1.14% | ||
| 19 | BAKER BROS. ADVISORS LP | 230,142 | 8,817,000 | 1.08% | ||
| 20 | STATE STREET CORP | 218,500 | 8,371,000 | 1.03% | ||
| 21 | MORGAN STANLEY | 208,597 | 7,991,000 | 0.98% | ||
| 22 | NORTHERN TRUST CORP | 191,702 | 7,344,000 | 0.90% | ||
| 23 | BlackRock Institutional Trust Company, N.A. | 173,597 | 6,651,000 | 0.82% | ||
| 24 | Cupps Capital Management, LLC | 164,199 | 6,290,000 | 0.77% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 122,444 | 4,690,000 | 0.58% | ||
| 26 | Invesco Ltd. | 118,590 | 4,543,000 | 0.56% | ||
| 27 | Ghost Tree Capital, LLC | 110,000 | 4,214,000 | 0.52% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 143,200 | 3,982,000 | 0.49% | Call | |
| 29 | Bank of New York Mellon Corp | 85,837 | 3,289,000 | 0.40% | ||
| 30 | Jefferies Group LLC | 85,000 | 3,256,000 | 0.40% | Put | |
| 31 | PointState Capital LP | 80,000 | 3,065,000 | 0.38% | ||
| 32 | RENAISSANCE TECHNOLOGIES LLC | 79,112 | 3,031,000 | 0.37% | ||
| 33 | TWO SIGMA INVESTMENTS, LP | 65,783 | 2,520,000 | 0.31% | ||
| 34 | Jefferies Group LLC | 65,350 | 2,504,000 | 0.31% | ||
| 35 | Rock Springs Capital Management LP | 65,000 | 2,490,000 | 0.31% | ||
| 36 | MILLENNIUM MANAGEMENT LLC | 88,900 | 2,472,000 | 0.30% | Put | |
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 64,386 | 2,467,000 | 0.30% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 59,000 | 2,260,000 | 0.28% | Call | |
| 39 | EVENTIDE ASSET MANAGEMENT, LLC | 58,300 | 2,233,000 | 0.27% | ||
| 40 | Atika Capital Management LLC | 57,500 | 2,203,000 | 0.27% | ||
| 41 | SPHERA FUNDS MANAGEMENT LTD. | 55,000 | 2,107,000 | 0.26% | ||
| 42 | Spark Investment Management LLC | 52,600 | 2,013,000 | 0.25% | ||
| 43 | BlackRock Investment Management, LLC | 48,552 | 1,860,000 | 0.23% | ||
| 44 | WEXFORD CAPITAL LP | 48,195 | 1,846,000 | 0.23% | ||
| 45 | Weiss Multi-Strategy Advisers LLC | 40,000 | 1,532,000 | 0.19% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 39,500 | 1,513,000 | 0.19% | Put | |
| 47 | Granahan Investment Management, LLC | 33,894 | 1,298,000 | 0.16% | ||
| 48 | GOLDMAN SACHS GROUP INC | 32,202 | 1,233,000 | 0.15% | ||
| 49 | ProShare Advisors LLC | 31,133 | 1,193,000 | 0.15% | ||
| 50 | Absolute Return Capital, LLC | 27,665 | 1,060,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
