| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Woodford Investment Management Ltd | 9,296,361 | 382,638,000 | 26.27% | ||
| 2 | FMR LLC | 5,146,009 | 211,810,000 | 14.54% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,327,983 | 136,980,000 | 9.40% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 3,216,685 | 132,398,000 | 9.09% | ||
| 5 | BlackRock Fund Advisors | 1,248,919 | 51,406,000 | 3.53% | ||
| 6 | STATE STREET CORP | 1,224,523 | 50,406,000 | 3.46% | ||
| 7 | Visium Asset Management, LP | 891,829 | 36,709,000 | 2.52% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 846,698 | 34,850,000 | 2.39% | ||
| 9 | Palo Alto Investors LP | 695,518 | 28,628,000 | 1.97% | ||
| 10 | VANGUARD GROUP INC | 568,084 | 23,382,000 | 1.61% | ||
| 11 | PINNACLE ASSOCIATES LTD | 441,344 | 18,166,000 | 1.25% | ||
| 12 | ALLIANCEBERNSTEIN L.P. | 417,076 | 17,167,000 | 1.18% | ||
| 13 | WELLS FARGO & COMPANY/MN | 416,736 | 17,152,000 | 1.18% | ||
| 14 | JENNISON ASSOCIATES LLC | 410,695 | 16,904,000 | 1.16% | ||
| 15 | SECTORAL ASSET MANAGEMENT INC | 398,100 | 16,386,000 | 1.13% | ||
| 16 | NORTHERN TRUST CORP | 386,001 | 15,887,000 | 1.09% | ||
| 17 | OAK RIDGE INVESTMENTS LLC | 371,572 | 15,294,000 | 1.05% | ||
| 18 | BB BIOTECH AG | 350,000 | 14,406,000 | 0.99% | ||
| 19 | NORGES BANK | 330,053 | 13,585,000 | 0.93% | ||
| 20 | Rock Springs Capital Management LP | 308,000 | 12,677,000 | 0.87% | ||
| 21 | Invesco Ltd. | 285,939 | 11,769,000 | 0.81% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 251,692 | 10,359,000 | 0.71% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 248,522 | 10,229,000 | 0.70% | ||
| 24 | AXA S.A. | 191,285 | 7,873,000 | 0.54% | ||
| 25 | TURNER INVESTMENTS LLC | 186,300 | 7,669,000 | 0.53% | ||
| 26 | VOYA INVESTMENT MANAGEMENT LLC | 186,223 | 7,664,000 | 0.53% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 162,870 | 6,704,000 | 0.46% | ||
| 28 | Bank of New York Mellon Corp | 160,753 | 6,617,000 | 0.45% | ||
| 29 | COLUMBUS CIRCLE INVESTORS | 150,562 | 6,197,000 | 0.43% | ||
| 30 | BLACKROCK ADVISORS LLC | 129,949 | 5,349,000 | 0.37% | ||
| 31 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 125,100 | 5,149,000 | 0.35% | Put | |
| 32 | CREDIT SUISSE AG/ | 124,030 | 5,106,000 | 0.35% | ||
| 33 | BlackRock Investment Management, LLC | 123,063 | 5,065,000 | 0.35% | ||
| 34 | EVENTIDE ASSET MANAGEMENT, LLC | 120,000 | 4,939,000 | 0.34% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 118,492 | 4,878,000 | 0.33% | ||
| 36 | MARSHALL WACE, LLP | 117,937 | 4,854,000 | 0.33% | ||
| 37 | OppenheimerFunds, Inc. | 107,665 | 4,431,000 | 0.30% | ||
| 38 | GUGGENHEIM CAPITAL LLC | 106,572 | 4,386,000 | 0.30% | ||
| 39 | Employees Retirement System of Texas | 106,000 | 4,363,000 | 0.30% | ||
| 40 | JPMORGAN CHASE & CO | 90,556 | 3,727,000 | 0.26% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 89,500 | 3,684,000 | 0.25% | Put | |
| 42 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 82,300 | 3,387,000 | 0.23% | ||
| 43 | PUTNAM INVESTMENTS LLC | 80,445 | 3,311,000 | 0.23% | ||
| 44 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 78,200 | 3,219,000 | 0.22% | Call | |
| 45 | ROYAL BANK OF CANADA | 76,058 | 3,130,000 | 0.21% | ||
| 46 | GOLDMAN SACHS GROUP INC | 75,993 | 3,127,000 | 0.21% | ||
| 47 | TEACHERS ADVISORS, LLC | 75,422 | 3,104,000 | 0.21% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 71,900 | 2,959,000 | 0.20% | Call | |
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 71,754 | 2,953,000 | 0.20% | ||
| 50 | PRUDENTIAL FINANCIAL INC | 71,270 | 2,933,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
