| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Woodford Investment Management Ltd | 10,310,511 | 507,174,000 | 27.12% | ||
| 2 | FMR LLC | 5,173,264 | 254,473,000 | 13.61% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,315,177 | 163,074,000 | 8.72% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 3,019,033 | 148,506,000 | 7.94% | ||
| 5 | BlackRock Fund Advisors | 1,515,241 | 74,535,000 | 3.99% | ||
| 6 | Capital World Investors | 1,323,114 | 65,084,000 | 3.48% | ||
| 7 | STATE STREET CORP | 1,085,411 | 53,392,000 | 2.85% | ||
| 8 | Palo Alto Investors LP | 993,855 | 48,888,000 | 2.61% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 872,281 | 42,908,000 | 2.29% | ||
| 10 | ALLIANCEBERNSTEIN L.P. | 823,315 | 40,499,000 | 2.17% | ||
| 11 | Redmile Group, LLC | 653,725 | 32,157,000 | 1.72% | ||
| 12 | VANGUARD GROUP INC | 602,227 | 29,624,000 | 1.58% | ||
| 13 | OAK RIDGE INVESTMENTS LLC | 481,027 | 23,662,000 | 1.27% | ||
| 14 | JENNISON ASSOCIATES LLC | 409,582 | 20,147,000 | 1.08% | ||
| 15 | PINNACLE ASSOCIATES LTD | 405,972 | 19,970,000 | 1.07% | ||
| 16 | NORTHERN TRUST CORP | 395,428 | 19,452,000 | 1.04% | ||
| 17 | WELLS FARGO & COMPANY/MN | 371,810 | 18,290,000 | 0.98% | ||
| 18 | NORGES BANK | 371,553 | 18,277,000 | 0.98% | ||
| 19 | BB BIOTECH AG | 350,000 | 17,217,000 | 0.92% | ||
| 20 | WESTFIELD CAPITAL MANAGEMENT CO LP | 328,275 | 16,148,000 | 0.86% | ||
| 21 | Rock Springs Capital Management LP | 309,500 | 15,224,000 | 0.81% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 281,338 | 13,839,000 | 0.74% | ||
| 23 | Invesco Ltd. | 262,244 | 12,900,000 | 0.69% | ||
| 24 | VOYA INVESTMENT MANAGEMENT LLC | 247,481 | 12,173,000 | 0.65% | ||
| 25 | LOOMIS SAYLES & CO L P | 195,970 | 9,640,000 | 0.52% | ||
| 26 | Hood River Capital Management LLC | 179,789 | 8,844,000 | 0.47% | ||
| 27 | OppenheimerFunds, Inc. | 167,780 | 8,253,000 | 0.44% | ||
| 28 | Bank of New York Mellon Corp | 161,573 | 7,947,000 | 0.42% | ||
| 29 | AXA S.A. | 156,542 | 7,700,000 | 0.41% | ||
| 30 | MORGAN STANLEY | 139,589 | 6,867,000 | 0.37% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 137,192 | 6,749,000 | 0.36% | ||
| 32 | BlackRock Investment Management, LLC | 132,680 | 6,527,000 | 0.35% | ||
| 33 | CREDIT SUISSE AG/ | 127,944 | 6,294,000 | 0.34% | ||
| 34 | SECTORAL ASSET MANAGEMENT INC | 123,646 | 6,082,000 | 0.33% | ||
| 35 | EVENTIDE ASSET MANAGEMENT, LLC | 120,000 | 5,903,000 | 0.32% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 117,378 | 5,774,000 | 0.31% | ||
| 37 | AMUNDI ASSET MANAGEMENT US, INC. | 116,424 | 5,727,000 | 0.31% | ||
| 38 | Employees Retirement System of Texas | 106,000 | 5,214,000 | 0.28% | ||
| 39 | CITIGROUP INC | 94,765 | 4,661,000 | 0.25% | ||
| 40 | JPMORGAN CHASE & CO | 91,580 | 4,504,000 | 0.24% | ||
| 41 | COLUMBUS CIRCLE INVESTORS | 89,052 | 4,380,000 | 0.23% | ||
| 42 | Opaleye Management Inc. | 82,500 | 4,058,000 | 0.22% | ||
| 43 | BLACKROCK ADVISORS LLC | 82,435 | 4,055,000 | 0.22% | ||
| 44 | DEUTSCHE BANK AG\ | 80,093 | 3,938,000 | 0.21% | ||
| 45 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 75,000 | 3,689,000 | 0.20% | ||
| 46 | TEACHERS ADVISORS, LLC | 72,604 | 3,571,000 | 0.19% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 71,631 | 3,524,000 | 0.19% | ||
| 48 | GOLDMAN SACHS GROUP INC | 71,494 | 3,516,000 | 0.19% | ||
| 49 | GUGGENHEIM CAPITAL LLC | 61,758 | 3,037,000 | 0.16% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 61,100 | 3,006,000 | 0.16% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
